Yong Wang
Professor of Biomedical Engineering
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232 Hallowell Bldg
University Park, PA - yxw30@psu.edu
- 814-865-6867
Research Summary
Applying nature and biology as design guidelines to the creation of biomimetic and bioinspired materials at both the nanoscale and macroscale level for drug delivery, clinical diagnosis, and regenerative medicine.
Huck Affiliations
Most Recent Publications
Ushering in the era of regenerative surgery
Olivia P. Waldron, Jessica C. El-Mallah, Dev Lochan, Connie Wen, Mary E. Landmesser, Mohammadhossein Asgardoon, Jazzmyn Dawes, Summer N. Horchler, Kevin Schlidt, Shailaja Agrawal, Yong Wang, Dino J. Ravnic, 2024, Minerva Surgery on p. 166-182
Biomimetic Bacterial Capsule for Enhanced Aptamer Display and Cell Recognition
Xuelin Wang, Bei Jia, Kyungsene Lee, Brandon Davis, Connie Wen, Yixun Wang, Hong Zheng, Yong Wang, 2024, Journal of the American Chemical Society on p. 868-877
Nanofluidic Aptamer Nanoarray to Enable Stochastic Capture of Single Proteins at Normal Concentrations
Jinbin Yang, Hiroki Kamai, Yong Wang, Yan Xu, 2023, Small
Deoxyribonucleic Acid-Based Polyvalent Ligand-Receptor Binding for Engineering the Cell Surface with Nanoparticles
Brandon Davis, Kyungsene Lee, Xuelin Wang, Yong Wang, 2023, Biomacromolecules on p. 3193-3202
Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis
Rubia Shaik, Jiazhu Xu, Yong Wang, Yi Hong, Ge Zhang, 2023, ACS Biomaterials Science and Engineering on p. 877-888
Nanoparticle-Decorated Biomimetic Extracellular Matrix for Cell Nanoencapsulation and Regulation
Kyungsene Lee, Brandon Davis, Xuelin Wang, Shubham Mirg, Connie Wen, Lidya Abune, Benjamin E. Peterson, Li Han, Haoyang Chen, Hongjun Wang, Spencer E. Szczesny, Yuguo Lei, Sri Rajasekhar Kothapalli, Yong Wang, 2023, Angewandte Chemie - International Edition on p. e202306583
High-affinity one-step aptamer selection using a non-fouling porous hydrogel
Naveen K. Singh, Yixun Wang, Connie Wen, Brandon Davis, Xuelin Wang, Kyungsene Lee, Yong Wang, 2023, Nature Biotechnology
Elastic Macroporous Matrix-Supported In Situ Formation of Injectable Extracellular Matrix-Like Hydrogel for Carrying Growth Factors and Living Cells
Lidya Abune, Connie Wen, Kyungsene Lee, Xuelin Wang, Dino Ravnic, Yong Wang, 2023, Macromolecular Bioscience
Display of Polyvalent Hybrid Antibodies on the Cell Surface for Enhanced Cell Recognition
Xuelin Wang, Yixun Wang, Kyungsene Lee, Brandon Davis, Connie Wen, Bei Jia, Hong Zheng, Cheng Dong, Yong Wang, 2023, Small Methods
Fabricating 3-dimensional human brown adipose microtissues for transplantation studies
O Wang, L Han, H Lin, M Tian, S Zhang, B Duan, S Chung, C Zhang, Xiaojun Lian, Y Wang, Yuguo Lei, 2022, Bioactive Materials on p. 518-534
Most-Cited Papers
Programmable hydrogels
Yong Wang, 2018, Biomaterials on p. 663-680
DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells
Peng Shi, Nan Zhao, James Coyne, Yong Wang, 2019, Nature Communications
In Situ Synthesis of an Aptamer-Based Polyvalent Antibody Mimic on the Cell Surface for Enhanced Interactions between Immune and Cancer Cells
Peng Shi, Xuelin Wang, Brandon Davis, James Coyne, Cheng Dong, Joshua Reynolds, Yong Wang, 2020, Angewandte Chemie - International Edition on p. 11892-11897
Aptamer-functionalized superporous hydrogels for sequestration and release of growth factors regulated via molecular recognition
Mark R. Battig, Yike Huang, Niancao Chen, Yong Wang, 2014, Biomaterials on p. 8040-8048
Polyvalent Display of Biomolecules on Live Cells
Peng Shi, Nan Zhao, Jinping Lai, James Coyne, Erin R. Gaddes, Yong Wang, 2018, Angewandte Chemie - International Edition on p. 6800-6804
Affinity Hydrogels for Protein Delivery
Lidya Abune, Yong Wang, 2021, Trends in Pharmacological Sciences on p. 300-312
Optical-resolution photoacoustic microscopy using transparent ultrasound transducer
Haoyang Chen, Sumit Agrawal, A Dangi, Christopher Wible, Mohamed Osman, Lidya Abune, Huizhen Jia, Randall Rossi, Yong Wang, Sri-Rajasekhar Kothapalli, 2019, Sensors on p. 5470
Chimeric Aptamer-Gelatin Hydrogels as an Extracellular Matrix Mimic for Loading Cells and Growth Factors
Xiaolong Zhang, Mark R. Battig, Niancao Chen, Erin R. Gaddes, Katelyn L. Duncan, Yong Wang, 2016, Biomacromolecules on p. 778-787
Synthetic DNA for Cell-Surface Engineering
Peng Shi, Yong Wang, 2021, Angewandte Chemie - International Edition on p. 11580-11591
Assembly of Bifunctional Aptamer-Fibrinogen Macromer for VEGF Delivery and Skin Wound Healing
Nan Zhao, James Coyne, Ming Xu, Xiaolong Zhang, Akiho Suzuki, Peng Shi, Jinping Lai, Guo Hua Fong, Na Xiong, Yong Wang, 2019, Chemistry of Materials on p. 1006-1015
News Articles Featuring Yong Wang
Aug 07, 2024
Biomedical engineer to use $2M NIH grant to improve human tissue repair
A team of Penn State researchers led by Wang was recently awarded a four-year, $2.02 million National Institutes of Health grant to explore how to safely add growth factors to collagen used by doctors for tissue repair.
Full Article
Oct 06, 2023
Novel hydrogel finds new aptamers, or ‘chemical antibodies,’ in days
One double-helix strand of DNA could extend six feet, but it is so tightly coiled that it packs an entire sequence of nucleotides into the tiny nucleus of a cell. If that same DNA was instead split into two strands and divided into many, many short pieces, it would become trillions of uniquely folded 3D molecular structures, capable of bonding to and possibly manipulating specifically shaped molecules — if they’re the perfect fit.
Full Article
Apr 20, 2020
Penn State engineer aims to tackle COVID-19 from two angles
To combat COVID-19 in both the treatment and testing arenas, Yong Wang, Penn State professor of biomedical engineering, has received two grants from the Huck Institutes of the Life Sciences COVID-19 multi-institute seed grant fund.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article