Wen Jiang

Faculty Director of the Cryo-Electron Microscopy Core Facility; Professor of Biochemistry & Molecular Biology

Wen Jiang

Huck Affiliations

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Most Recent Publications

Pseudovirus nanoparticles targeting the receptor binding HA1 domains of influenza viruses elicited high HA1-specific antibody responses and protected mice against mortality caused by influenza virus challenges

Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Ming Tan, 2025, Vaccine

A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and Plasmodium as a Combination Vaccine Candidate

Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan, 2025, Vaccines

Cryo-EM structures of cotton wool plaques’ amyloid β and of tau filaments in dominantly inherited Alzheimer disease

Md Rejaul Hoq, Anllely Fernandez, Frank S. Vago, Grace I. Hallinan, Sakshibeedu R. Bharath, Daoyi Li, Kadir A. Ozcan, Holly J. Garringer, Wen Jiang, Ruben Vidal, Bernardino Ghetti, 2024, Acta Neuropathologica

A Pseudovirus Nanoparticle Displaying the Vaccinia Virus L1 Protein Elicited High Neutralizing Antibody Titers and Provided Complete Protection to Mice against Mortality Caused by a Vaccinia Virus Challenge

Pengwei Huang, Ming Xia, Frank S. Vago, Wen Jiang, Ming Tan, 2024, Vaccines

Cryo-EM structures of amyloid-β and tau filaments in Down syndrome

Anllely Fernandez, Md Rejaul Hoq, Grace I. Hallinan, Daoyi Li, Sakshibeedu R. Bharath, Frank S. Vago, Xiaoqi Zhang, Kadir A. Ozcan, Kathy L. Newell, Holly J. Garringer, Wen Jiang, Bernardino Ghetti, Ruben Vidal, 2024, Nature Structural Biology on p. 903-909

A Viral Protein 4-Based Trivalent Nanoparticle Vaccine Elicited High and Broad Immune Responses and Protective Immunity against the Predominant Rotaviruses

Ming Xia, Pengwei Huang, Frank Vago, Takahiro Kawagishi, Siyuan Ding, Harry B. Greenberg, Wen Jiang, Ming Tan, 2024, ACS Nano on p. 6673-6689

The 2.6 Å Structure of a Tulane Virus Variant with Minor Mutations Leading to Receptor Change

Chen Sun, Pengwei Huang, Xueyong Xu, Frank S. Vago, Kunpeng Li, Thomas Klose, Xi Jason Jiang, Wen Jiang, 2024, Biomolecules

Classification of helical polymers with deep-learning language models

Daoyi Li, Wen Jiang, 2023, Journal of Structural Biology

Pseudovirus Nanoparticles Displaying Plasmodium Circumsporozoite Proteins Elicited High Titers of Sporozoite-Binding Antibody

Ming Xia, Pengwei Huang, Frank Vago, Wen Jiang, Ming Tan, 2023, Vaccines

A bioengineered pseudovirus nanoparticle displaying SARS-CoV 2 RBD fully protects mice from mortality and weight loss caused by SARS-CoV 2 challenge

Ming Xia, Krisangel López, Frank S. Vago, Pengwei Huang, Dawn I. Auguste, Wen Jiang, Albert J. Auguste, Ming Tan, 2023, Biotechnology Journal

Most-Cited Papers

Self-Assembly of Molecule-like Nanoparticle Clusters Directed by DNA Nanocages

Yulin Li, Zhiyu Liu, Guimei Yu, Wen Jiang, Chengde Mao, 2015, Journal of the American Chemical Society on p. 4320-4323

Structure of the immature Zika virus at 9 A resolution

Vidya Mangala Prasad, Andrew S. Miller, Thomas Klose, Devika Sirohi, Geeta Buda, Wen Jiang, Richard J. Kuhn, Michael G. Rossmann, 2017, Nature Structural Biology on p. 184-186

A human antibody against Zika virus crosslinks the E protein to prevent infection

S. Saif Hasan, Andrew Miller, Gopal Sapparapu, Estefania Fernandez, Thomas Klose, Feng Long, Andrei Fokine, Jason C. Porta, Wen Jiang, Michael S. Diamond, James E. Crowe, Richard J. Kuhn, Michael G. Rossmann, 2017, Nature Communications

In vivo production of RNA nanostructures via programmed folding of single-stranded RNAs

Mo Li, Mengxi Zheng, Siyu Wu, Cheng Tian, Di Liu, Yossi Weizmann, Wen Jiang, Guansong Wang, Chengde Mao, 2018, Nature Communications

Accurate model annotation of a near-atomic resolution cryo-EM map

Corey F. Hryc, Dong Hua Chen, Pavel V. Afonine, Joanita Jakan, Zhao Wang, Cameron Haase-Pettingell, Wen Jiang, Paul D. Adams, Jonathan A. King, Michael F. Schmid, Wah Chiu, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 3103-3108

Self-assembly of responsive multilayered DNA nanocages

Zhiyu Liu, Cheng Tian, Jinwen Yu, Yulin Li, Wen Jiang, Chengde Mao, 2015, Journal of the American Chemical Society on p. 1730-1733

2.9 Å Resolution Cryo-EM 3D Reconstruction of Close-Packed Virus Particles

Zheng Liu, Fei Guo, Feng Wang, Tian Cheng Li, Wen Jiang, 2016, Structure with Folding & design on p. 319-328

Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-Å resolution and its relevance to the assembly of icosahedral viruses

Zhenguo Chen, Lei Sun, Zhihong Zhang, Andrei Fokine, Victor Padilla-Sanchez, Dorit Hanein, Wen Jiang, Michael G. Rossmann, Venigalla B. Rao, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. E8184-E8193

De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism

Jinwen Yu, Zhiyu Liu, Wen Jiang, Guansong Wang, Chengde Mao, 2015, Nature Communications

Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma

Yue Liu, Marchel G. Hill, Thomas Klose, Zhenguo Chen, Kelly Watters, Yury A. Bochkov, Wen Jiang, Ann C. Palmenberg, Michael G. Rossmann, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 8997-9002