Wansheng Liu
Professor of Genomics
-
Wm Henning Bldg
University Park, - wul12@psu.edu
- 814-867-1673
Research Summary
Functional annotation of farm animal genomes, structure and function of mammalian sex (X and Y) chromosome, spermatogenesis and male fertility.
Huck Affiliations
Publication Tags
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Cattle Genes Micrornas Microrna Y Chromosome Breed Ancestry Corpus Luteum Rna Sex Chromosomes Rna, Transfer, Gln Fertility Transfer Rna Taurine Americans Breeds Y Linked Genes Testicular Neoplasms Spermatozoa Mammalian Chromosomes Holstein Gametogenesis Messenger Rna Ovary Function Chromosome StructuresMost Recent Publications
Sheep Overview
Wansheng Liu, Tumen Wuliji, T Ott, Encyclopedia of Reproduction
Integrative Annotation of the Bovine Genome
Dailu Guan, Wansheng Liu, PAG XXXI, January 12-17, 2024, San Diego, CA. PO0461.
Differentially Expressed Genes during Different Developmental Stages of Testis in Cattle.
Wansheng Liu, Waqar Bahtti, PAG XXXI, January 12-17, 2024, San Diego, CA. PE0464
PRAMEY- a sperm-carried protein that influences paternal DNA methylation in zygotes
Chandlar Kern, Wansheng Liu, 56th Annual SSR Meeting, Ottawa, Canada.
Epigenomic Regulation of Gene Transcription across Tissues at Different Developmental Stages.
Huaijun Zhou, Wansheng Liu, PAG XXXI, January 12-17, 2024, San Diego, CA.
Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis
M Yang, Francisco Diaz, Krause ART, Ana Rita T. Krause, Yuguo Lei, Wan Sheng Liu, 2024, Cell and Bioscience on p. 28
Enhanced Bovine Genome Annotation Through Integration of Transcriptomics and Epi-Genetics Datasets Facilitates Genomic Biology.
H Beiki, Wansheng Liu, 2024, GigaScience
Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep
Jiankui Wang, Guoying Hua, Jianfei Chen, Kai Cui, Zu Yang, Deping Han, Xue Yang, Xianggui Dong, Yuhao Ma, Ganxian Cai, Yuanyuan Zhang, Jinnan Li, Yurong Tai, Lai Da, Xinhai Li, Lina Ma, Qing Ma, Rui Li, Jianbin Liu, Hesham Y.A. Darwish, Keliang Wu, Weiheng Rong, Wansheng Liu, Yaofeng Zhao, Xuemei Deng, 2023, Cell and Bioscience
PRAMEY- a sperm-carried protein that influences paternal DNA methylation in zygotes.
Chandlar Kern, Wansheng Liu, 2023, 38th Annual Graduate Exhibition. University Park, PA.
Complementary functions of Pramex1 and Pramel1 during spermatogenesis as revealed by Pramex1/Pramel1 double knockout mice.
Mkingyao Yang, Y Lei, Wansheng Liu, 2023, 38th Annual Graduate Exhibition, Penn State
Most-Cited Papers
Worldwide Patterns of Ancestry, Divergence, and Admixture in Domesticated Cattle
Jared E. Decker, Stephanie D. McKay, Megan M. Rolf, Jae Woo Kim, Antonio Molina Alcalá, Tad S. Sonstegard, Olivier Hanotte, Anders Götherström, Christopher M. Seabury, Lisa Praharani, Masroor Ellahi Babar, Luciana Correia de Almeida Regitano, Mehmet Ali Yildiz, Michael P. Heaton, Wan Sheng Liu, Chu Zhao Lei, James M. Reecy, Muhammad Saif-Ur-Rehman, Robert D. Schnabel, Jeremy F. Taylor, 2014, PLoS Genetics
MicroRNA in ovarian function
S. W. Maalouf, W. S. Liu, J. L. Pate, 2016, Cell and Tissue Research on p. 7-18
Superconductivity in the half-Heusler compound TbPdBi
H. Xiao, T. Hu, W. Liu, Y.L. Zhu, P.G. Li, G. Mu, J. Su, K. Li, Z.Q. Mao, 2018, Physical Review B-Condensed Matter
Copy number variations of the extensively amplified Y-linked genes, HSFY and ZNF280BY, in cattle and their association with male reproductive traits in Holstein bulls
Xiang Peng Yue, Chad Dechow, Ti Cheng Chang, James M. DeJarnette, Clifton E. Marshall, Chu Zhao Lei, Wan Sheng Liu, 2014, BMC Genomics
Early cleavage of preimplantation embryos is regulated by tRNA<sup>Gln-TTG</sup>-derived small RNAs present in mature spermatozoa
Xiaoxu Chen, Yi Zheng, Anmin Lei, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu, Chuanying Pan, Wuzi Dong, Hong Chen, De Wu, Wansheng Liu, Geert Hamer, Shenming Zeng, Wenxian Zeng, 2020, Journal of Biological Chemistry on p. 10885-10900
Regulating life or death: Potential role of microRNA in rescue of the corpus luteum
Samar W. Maalouf, Wan Sheng Liu, Istvan Albert, Joy L. Pate, 2014, Molecular and Cellular Endocrinology on p. 78-88
Mammalian Sex Chromosome Structure, Gene Content, and Function in Male Fertility
Wan Sheng Liu, 2019, Annual Review of Animal Biosciences on p. 103-124
A limited number of Y chromosome lineages is present in North American Holsteins
Xiang Peng Yue, Chad Dechow, Wan Sheng Liu, 2015, Journal of Dairy Science on p. 2738-2745
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis
Chandlar H. Kern, Mingyao Yang, Wan Sheng Liu, 2021, Biology of Reproduction on p. 290-304
Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue
Camilla K. Hughes, Samar W. Maalouf, Wansheng Liu, Joy L. Pate, 2019, Biology of Reproduction on p. 1581–1596
News Articles Featuring Wansheng Liu
Dec 07, 2023
USDA grant supports reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, US$238,500 grant to establish a graduate training pipeline in reproductive microbiome research
Full Article
Dec 06, 2023
New USDA grant to support graduate reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, $238,500 grant to establish a graduate training pipeline in reproductive microbiome research.
Full Article
Oct 23, 2023
Gene integral to initiating, sustaining sperm cell development identified
With male infertility a mounting global concern impacting approximately 12% of men, a Penn State research team has discovered a gene that plays a key role in initiating and sustaining spermatogenesis. The finding may open a door for future therapies to boost sperm counts.
Full Article