Vivek Kapur

Associate Director, Huck Institutes of the Life Sciences; Huck Distinguished Chair in Global Health; Professor of Microbiology and Infectious Diseases

Vivek Kapur

Research Summary

The basic mechanisms by which pathogenic microbes successfully infect, colonize, and cause disease in their hosts.

Huck Graduate Students

Huck Affiliations

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Publication Tags

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Tuberculosis India Animals Caprine Model Bovine Tuberculosis Escherichia Coli O Antigens Infections Deer Mycobacterium Coronavirus Mycobacterium Tuberculosis Viruses Multigene Family Oral Vaccine Terminology Small Intestine Meta Analysis Infection Proteins Severe Acute Respiratory Syndrome Zoonoses Nutrients Cattle Vaccines

Most Recent Publications

Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A. Williams, Simonette Palmer, John Clarke, Amanda O’Brien, Andrew J.K. Conlan, Nick Juleff, H. Martin Vordermeier, Gareth J. Jones, Vivek Kapur, 2024, Scientific Reports

Comparative analysis of tuberculin and defined antigen skin tests for detection of bovine tuberculosis in buffaloes (Bubalus bubalis) in Haryana state, India

Mohit Kumar, Tarun Kumar, Babu Lal Jangir, Mahavir Singh, Devan Arora, Yogesh Bangar, Andrew Conlan, Martin Vordermeier, Douwe Bakker, S. M. Byregowda, Sreenidhi Srinivasan, Vivek Kapur, Naresh Jindal, 2024, BMC Veterinary Research

Zoonotic tuberculosis in the 21st century

S Duffy, B Marais, Vivek Kapur, M Behr, 2024, The Lancet Infectious Diseases on p. 339-341

BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination

Abebe Fromsa, Katriina Willgert, Sreenidhi Srinivasan, Getnet Mekonnen, Wegene Bedada, Balako Gumi, Matios Lakew, Biniam Tadesse, Berecha Bayissa, Asegedech Sirak, Musse Girma Abdela, Solomon Gebre, Tesfaye Chibssa, Maroudam Veerasami, H. Martin Vordermeier, Douwe Bakker, Stefan Berg, Gobena Ameni, Nick Juleff, Mart C.M. de Jong, James Wood, Andrew Conlan, Vivek Kapur, 2024, Science on p. 1433-1441

Molecular detection and characterization of the Mycobacterium tuberculosis complex subspecies responsible for bovine tuberculosis in Punjab, Pakistan

Rubab Maqsood, Shannon C. Duffy, Hamad Bin Rashid, Shakera Sadiq Gill, Chanda Jabeen, Nimra Arshad, Gulshan Umbreen, Marcel A. Behr, Vivek Kapur, Mamoona Chaudhry, 2024, Microbiology spectrum

An imputed ancestral reference genome for the Mycobacterium tuberculosis complex better captures structural genomic diversity for reference-based alignment workflows

Luke B. Harrison, Vivek Kapur, Marcel A. Behr, 2024, Microbial genomics

SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode

Jule Goike, Ching Lin Hsieh, Andrew P. Horton, Elizabeth C. Gardner, Ling Zhou, Foteini Bartzoka, Nianshuang Wang, Kamyab Javanmardi, Andrew Herbert, Shawn Abbassi, Xuping Xie, Hongjie Xia, Pei Yong Shi, Rebecca Renberg, Thomas H. Segall-Shapiro, Cynthia I. Terrace, Wesley Wu, Raghav Shroff, Michelle Byrom, Andrew D. Ellington, Edward M. Marcotte, James M. Musser, Suresh V. Kuchipudi, Vivek Kapur, George Georgiou, Scott C. Weaver, John M. Dye, Daniel R. Boutz, Jason S. McLellan, Jimmy D. Gollihar, 2023, Communications Biology

Complete genome of a 2014 isolate of peste des petits ruminants virus from Ethiopia

Simon King, Michael D. Baron, Menbere Kidane, Fasil Aklilu, Vivek Kapur, Catherine M. Herzog, Carrie Batten, 2023, Genome Announcements

Clinical features of human tuberculosis due to Mycobacterium orygis in Southern India

Lydia Jennifer Sumanth, Christina Rachel Suresh, Manigandan Venkatesan, Abi Manesh, Marcel A. Behr, Vivek Kapur, Joy Sarojini Michael, 2023, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

Emergence of Mycobacterium orygis-Associated Tuberculosis in Wild Ruminants, India

Megha Sharma, Karikalan Mathesh, Premanshu Dandapat, Asok Kumar Mariappan, Ravi Kumar, Soni Kumari, Vivek Kapur, Sushila Maan, Naresh Jindal, Nitish Bansal, Riyaz Kadiwar, Abhishek Kumar, Nitin Gupta, A. M. Pawde, A. K. Sharma, 2023, Emerging Infectious Diseases on p. 661-663

Most-Cited Papers

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer

Suresh V. Kuchipudi, Meera Surendran-Nair, R Ruden, M Yon, R Nissly, Kurt J. Vandegrift, R Nelli, Lingling Li, Bhushan Jayarao, Costas D. Maranas, N Levine, K Willgert, Andrew J.K. Conlan, Conlan AJK, R Olsen, J Davis, J Musser, Peter John Hudson, Vivek Kapur, 2022, Proceedings of the National Academy of Sciences of the United States of America

Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization

Eric Salazar, 23 names , Suresh Kuchipudi, Isabella Cattadori, Paul Christensen, Todd Eagar, Xin Yi, Picheng Zhao, Zhicheng Jin, S. Long, Randall Olsen, Jian Chen, Brian Castillo, Christopher Leveque, Dalton Towers, Jason Lavinder, Jimmy Gollihar, Jose Cardona, Gregory Ippolito, Ruth Nissly, Ian Bird, Denver Greenawalt, Randall Rossi, Abhinay Gontu, Sreenidhi Srinivasan, Indira Poojary, I Cattadori, Peter J. Hudson, Nicole Josleyn, Laura Prugar, Kathleen Huie, Andrew Herbert, David Bernard, John Dye, Vivek Kapur, James Musser, 2020, Journal of Clinical Investigation on p. 6728-6738

Comparison of O-antigen gene clusters of all O-serogroups of Escherichia coli and proposal for adopting a new nomenclature for O-typing

Chitrita DebRoy, Pina M. Fratamico, Xianghe Yan, Gian Marco Baranzoni, Yanhong Liu, David S. Needleman, Robert Tebbs, Catherine D. O'Connell, Adam Allred, Michelle Swimley, Michael Mwangi, Vivek Kapur, Juan A. Raygoza Garay, Elisabeth L. Roberts, Robab Katani, 2016, PLoS One on p. e0147434

Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection

Xiaohui Liu, Yi ling Wang, Jacky Wu, Jianjun Qi, Zihua Zeng, Quanyuan Wan, Zhenghu Chen, Pragya Manandhar, Victoria S. Cavener, Nina R. Boyle, Xinping Fu, Eric Salazar, Suresh V. Kuchipudi, Vivek Kapur, Xiaoliu Zhang, Michihisa Umetani, Mehmet Sen, Richard C. Willson, Shu hsia Chen, Youli Zu, 2021, Angewandte Chemie - International Edition on p. 10273-10278

Transmission of SARS-CoV-2 from humans to animals and potential host adaptation

Cedric C.S. Tan, Su Datt Lam, Damien Richard, Christopher J. Owen, Dorothea Berchtold, Christine Orengo, Meera Surendran Nair, Suresh V. Kuchipudi, Vivek Kapur, Lucy van Dorp, François Balloux, 2022, Nature Communications

Prevalence of Bovine Tuberculosis in India: A systematic review and meta-analysis

Sreenidhi Srinivasan, Laurel Easterling, Bipin Rimal, Xiaoyue Maggie Niu, Andrew J.K. Conlan, Patrick Dudas, Vivek Kapur, 2018, Transboundary and Emerging Diseases on p. 1627-1640

Reconsidering Mycobacterium bovis as a proxy for zoonotic tuberculosis: a molecular epidemiological surveillance study

Shannon C. Duffy, Sreenidhi Srinivasan, Megan A. Schilling, Tod Stuber, Sarah N. Danchuk, Joy S. Michael, Manigandan Venkatesan, Nitish Bansal, Sushila Maan, Naresh Jindal, Deepika Chaudhary, Premanshu Dandapat, Robab Katani, Shubhada Chothe, Maroudam Veerasami, Suelee Robbe-Austerman, Nicholas Juleff, Vivek Kapur, Marcel A. Behr, 2020, The Lancet Microbe on p. e66-e73

Evaluation of novel oral vaccine candidates and validation of a caprine model of Johne's disease

Murray E. Hines, Sue E. Turnquist, Marcia R.S. Ilha, Sreekumari Rajeev, Arthur L. Jones, Lisa Whittington, John P. Bannantine, Raúl G. Barletta, Yrjö T. Gröhn, Robab Katani, Adel M. Talaat, Lingling Li, Vivek Kapur, 2014, Frontiers in cellular and infection microbiology on p. 26

Impact of helminth infections and nutritional constraints on the small intestine microbiota

Isabella M. Cattadori, Aswathy Sebastian, Han Hao, Robab Katani, Istvan Albert, Kirsten E. Eilertson, Vivek Kapur, Ashutosh Pathak, Susan Mitchell, 2016, PLoS One on p. e0159770

A defined antigen skin test for the diagnosis of bovine tuberculosis

Sreenidhi Srinivasan, Gareth Jones, Maroudam Veerasami, Sabine Steinbach, Thomas Holder, Aboma Zewude, Abebe Fromsa, Gobena Ameni, Laurel Easterling, Douwe Bakker, Nicholas Juleff, Glen Gifford, R. G. Hewinson, H. Martin Vordermeier, Vivek Kapur, 2019, Science advances on p. eaax4899

News Articles Featuring Vivek Kapur

Mar 28, 2024

Vaccine protects cattle from bovine tuberculosis, may eliminate disease

Bovine tuberculosis (TB) is a livestock disease that results in large economic losses to animal agriculture worldwide. The disease can also transmit to humans and cause severe illness and death.

Full Article

Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Full Article

May 22, 2022

The Michigan Mink Mystery: How Did an Interspecies Outbreak Unfold?

The puzzling coronavirus cases highlight ongoing surveillance challenges and blind spots.

Full Article

Apr 07, 2022

Preventing, controlling spread of animal diseases focus of forum at Penn State

Exploring the emergence, spread and control of animal infectious diseases was the focus of the inaugural Emerging Animal Infectious Disease Conference held Nov. 29-Dec.1, 2021, at Penn State. It was hosted by the College of Agricultural Sciences, the Pennsylvania Department of Agriculture, and Penn State’s Center for Security Research and Education.

Full Article

Feb 22, 2022

The Coronavirus Menagerie

With the virus widespread in white-tailed deer, scientists wonder which animals might be next.

Full Article

Feb 21, 2022

Omicron detected for first time in white-tailed deer

Some white-tailed deer living in Staten Island, New York, are actively infected with the Omicron (B.1.1.529) variant of SARS-CoV-2, according to new research led by scientists at Penn State. The team also found neutralizing antibodies to SARS-CoV-2 in one of the Omicron-infected deer, suggesting that, like humans, deer can be reinfected with the virus.

Full Article

Feb 16, 2022

COVID-19 May Be Widespread in Deer

An analysis by Penn State and Iowa researchers found that Covid-19 may be fairly widespread among white-tailed deer. Up to 80 percent of the deer sampled in Iowa from April 2020 through January 2021 were infected with COVID-19. And The U.S. Department of Agriculture has confirmed Covid infections in deer in 15 states total.

Full Article

Feb 10, 2022

Omicron-Infected Whitetail Deer Detected in New York

The first cases of whitetail deer carrying the Omicron variant of the COVID-19 virus have been discovered in Staten Island, New York. Researchers there report that 19 of 131 deer sampled between December 12, 2021, and Janauary 31, 2022, tested positive for the virus’ antibodies, indicating prior exposure to the coronavirus. PCR (polymerase chain reaction) nasal swab testing of 68 deer revealed that seven were actively infected, with at least four of those confirmed to be Omicron.

Full Article

Feb 09, 2022

Omicron Has Been Found in Deer—That Should Worry Us

There are more than 30 million white-tailed deer in the U.S. That’s a boon for hunters, a headache for gardeners, a hazard for drivers—and now, it appears, a possible problem in the world’s ongoing effort to control the COVID-19 pandemic.

Full Article

Feb 08, 2022

Omicron found in NYC deer raises questions about COVID transmission from animals to humans

The discovery of deer in New York City infected with the omicron variant is raising questions about whether or not animals could potentially transmit COVID-19 to humans.

Full Article

Feb 08, 2022

Not just humans: Study finds NYC omicron spike hit deer too

When New York City’s COVID-19 rates spiked last December due to the emerging omicron variant, humans weren’t the only mammals affected.

Full Article

Feb 07, 2022

Is the Coronavirus in Your Backyard?

White-tailed deer could become a reservoir for the virus, putting people and animals at risk, health experts say.

Full Article

Feb 02, 2022

Scientists discover shockingly high rates of COVID infections among white-tailed deer

Scientists have recently discovered what they are calling a silent outbreak of coronavirus among white-tailed deer. William Brangham reports about how one of the most ubiquitous species in North America contracted COVID, and what that means for the future of the pandemic.

Full Article

Nov 10, 2021

How SARS-CoV-2 in American deer could alter the course of the global pandemic

Scientists have evidence that SARS-CoV-2 spreads explosively in white-tailed deer and that the virus is widespread in this deer population across the United States.

Full Article

Nov 04, 2021

Uh Oh, the Coronavirus Has Been Spreading Widely in U.S. Deer

Up to a third of deer in Iowa had recently been infected by SARS-CoV-2, according to one estimate.

Full Article

Nov 03, 2021

Deer in Iowa appear to be catching COVID-19 from humans. Could it happen in other states?

The coronavirus appears to have infected many of Iowa’s deer, posing risks the virus could mutate in the animals and then re-enter the human population in an altered version, a new study says.

Full Article

Nov 03, 2021

Wild deer are giving each other COVID—a lot

Animals hosting the virus may act as a reservoir.

Full Article

Nov 03, 2021

Scientists fear animals could harbor coronavirus and then pass it back to humans

“This also raises the possibility of the spillback from deer back to humans, especially in exurban areas with high deer densities,” researchers said.

Full Article

Nov 03, 2021

Research Suggests Extensive COVID-19 Infections In White-Tailed Deer

The majority of Iowa's white-tailed deer may already be infected with the coronavirus.

Full Article

Nov 03, 2021

Researchers Detect Coronavirus in Iowa Deer

Multiple white tailed deer tested positive for SARS-CoV-2 likely transmitted from humans, a study finds, indicating the species could act as a reservoir for the virus.

Full Article

Nov 03, 2021

Deer may be reservoir for SARS-CoV-2, study finds

The findings of a study by Penn State and Iowa researchers suggest that white-tailed deer may be a reservoir for the SARS-CoV-2 virus to continually circulate, and raises concerns of emergence of new strains that may prove a threat to wildlife and, possibly, to humans.

Full Article

Nov 02, 2021

Widespread Coronavirus Infection Found in Iowa Deer, New Study Says

The analysis by Penn State and Iowa researchers strongly indicates that deer are getting the virus from humans, worrying experts about a deep wild reservoir for the virus.

Full Article

Oct 15, 2021

Huck Welcomes Sindura Ganapathi as Visiting Fellow in Global Heath

Ganapathi, a Penn State alum who now works for the Indian government, will give a pair of lectures next week while he visits University Park.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.

Full Article