Troy Sutton

Associate Professor of Immunology and Infectious Disease

Troy Sutton

Research Summary

Animal models of influenza; Airborne transmission of influenza viruses; Evolution of pandemic influenza viruses; Highly pathogenic avian influenza; Development of live-attenuated influenza vaccine platforms; High containment BSL3+ research

Huck Affiliations

Publication Tags

These publication tags are generated from the output of this researcher. Click any tag below to view other Huck researchers working on the same topic.

Human Influenza Viruses Influenza A Virus Orthomyxoviridae Swine Genes Hemagglutinins Orthomyxoviridae Infections Animal Disease Models Pandemics Ferrets Neutralizing Antibodies Mutation Neutralization Tests Viral Antibodies Infections Infection Influenza In Birds Animals Proteins Pandemic Monoclonal Antibodies Viral Proteins Swine Diseases Dead Box Rna Helicases

Most Recent Publications

Risk assessment of a highly pathogenic H5N1 influenza virus from mink

Katherine H. Restori, Kayla M. Septer, Cassandra J. Field, Devanshi R. Patel, David VanInsberghe, Vedhika Raghunathan, Anice C. Lowen, Troy C. Sutton, 2024, Nature Communications

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model.

D Patel, A Minns, D Sim, C Field, A Kerr, T Heinly, E Luley, R Rossi, C Bator, I Moustafa, E Norton, S Hafenstein, S Lindner, Troy Sutton, 2024, Microbiology spectrum on p. e0499822

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton, 2024, Microbiology spectrum

Characterization of Mutations Enriched During Sequential Transmission of H7N9 Influenza Virus in Ferrets

Troy Sutton, 2023, Proceedings of NIAID Centers of Excellence for Influenza Research and Response 2nd Annual Conference

Neuraminidase immunity decreases viral shedding, but does not disrupt chains of airborne transmission for 2009 pandemic H1N1 in the ferret model.

Troy Sutton, 2023, Proceedings of NIAID Centers of Excellence for Influenza Research and Response 2nd Annual Conference

Virology under the Microscope—a Call for Rational Discourse

F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, Journal of Virology on p. e0008923

Virology under the Microscope—a Call for Rational Discourse

F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, mSphere on p. e0003423

Virology under the Microscope-a Call for Rational Discourse

F Goodrum, A Lowen, S Lakdawala, J Alwine, A Casadevall, M Imperiale, W Atwood, D Avgousti, J Baines, B Banfield, L Banks, S Bhaduri-McIntosh, D Bhattacharya, D Blanco-Melo, D Bloom, A Boon, S Boulant, C Brandt, A Broadbent, C Brooke, C Cameron, S Campos, P Caposio, G Chan, A Cliffe, J Coffin, K Collins, B Damania, M Daugherty, K Debbink, J DeCaprio, T Dermody, J Dikeakos, D DiMaio, R Dinglasan, W Duprex, R Dutch, N Elde, M Emerman, L Enquist, B Fane, A Fernandez-Sesma, M Flenniken, L Frappier, M Frieman, K Frueh, M Gack, M Gaglia, T Gallagher, D Galloway, A García-Sastre, A Geballe, B Glaunsinger, S Goff, A Greninger, M Hancock, E Harris, N Heaton, M Heise, E Heldwein, B Hogue, S Horner, E Hutchinson, J Hyser, W Jackson, R Kalejta, J Kamil, S Karst, F Kirchhoff, D Knipe, T Kowalik, M Lagunoff, L Laimins, R Langlois, A Lauring, B Lee, D Leib, S Liu, R Longnecker, C Lopez, M Luftig, J Lund, B Manicassamy, G McFadden, M McIntosh, A Mehle, W Miller, I Mohr, C Moody, N Moorman, A Moscona, B Mounce, J Munger, K Münger, E Murphy, M Naghavi, J Nelson, C Neufeldt, J Nikolich, C O'Connor, A Ono, W Orenstein, D Ornelles, J Ou, J Parker, C Parrish, A Pekosz, P Pellett, J Pfeiffer, R Plemper, S Polyak, J Purdy, D Pyeon, M Quinones-Mateu, R Renne, C Rice, J Schoggins, R Roller, C Russell, R Sandri-Goldin, M Sapp, L Schang, S Schmid, S Schultz-Cherry, B Semler, T Shenk, G Silvestri, V Simon, G Smith, J Smith, K Spindler, M Stanifer, K Subbarao, W Sundquist, M Suthar, Troy Sutton, A Tai, V Tarakanova, B tenOever, S Tibbetts, S Tompkins, Z Toth, K van Doorslaer, M Vignuzzi, N Wallace, D Walsh, M Weekes, J Weinberg, M Weitzman, S Weller, S Whelan, E White, B Williams, C Wobus, S Wong, A Yurochko, 2023, mBio on p. e0018823

Sequential Transmission of Influenza Viruses in Ferrets Does Not Enhance Infectivity and Does Not Predict Transmissibility in Humans

Troy C. Sutton, Elaine W. Lamirande, Devanshi R. Patel, Katherine E.E. Johnson, Rita Czako, Elodie Ghedin, Raphael T.C. Lee, Sebastian Maurer-Stroh, Kanta Subbarao, 2022, mBio

Transmission of Human Influenza A Virus in Pigs Selects for Adaptive Mutations on the HA Gene

Jong Suk Mo, Eugenio J. Abente, Matias Cardenas Perez, Troy C. Sutton, Brianna Cowan, Lucas M. Ferreri, Ginger Geiger, Phillip C. Gauger, Daniel R. Perez, Amy L. Vincent Baker, Daniela S. Rajao, 2022, Journal of Virology

Most-Cited Papers

The pandemic threat of emerging H5 and H7 avian influenza viruses

Troy C. Sutton, 2018, Viruses

Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States

D Rajão, P Gauger, T Anderson, N Lewis, E Abente, M Killian, D Perez, Troy Sutton, J Zhang, A Vincent, 2015, Journal of Virology on p. 11213-11222

Development of animal models against emerging coronaviruses: From SARS to MERS coronavirus

Troy C. Sutton, Kanta Subbarao, 2015, Virology on p. 247-258

Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody

Katherine V. Houser, Andrew J. Broadbent, Lisa Gretebeck, Leatrice Vogel, Elaine W. Lamirande, Troy Sutton, Kevin W. Bock, Mahnaz Minai, Marlene Orandle, Ian N. Moore, Kanta Subbarao, 2017, PLoS Pathogens

Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets

Troy C. Sutton, Courtney Finch, Hongxia Shao, Matthew Angel, Hongjun Chen, Ilaria Capua, Giovanni Cattoli, Isabella Monne, Daniel R. Pereza, 2014, Journal of Virology on p. 6623-6635

Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I

Weizhong Li, Hongjun Chen, Troy Sutton, Adebimpe Obadan, Daniel R. Perez, 2014, Journal of Virology on p. 10432-10447

Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines

Troy C. Sutton, Saborni Chakraborty, Vamsee V.A. Mallajosyula, Elaine W. Lamirande, Ketaki Ganti, Kevin W. Bock, Ian N. Moore, Raghavan Varadarajan, Kanta Subbarao, 2017, npj Vaccines

Alternative reassortment events leading to transmissible h9n1 influenza viruses in the ferret model

Brian J. Kimble, Matthew Angel, Hongquan Wan, Troy C. Sutton, Courtney Finch, Daniel R. Perez, 2014, Journal of Virology on p. 66-71

In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice

Troy C. Sutton, Elaine W. Lamirande, Kevin W. Bock, Ian N. Moore, Wouter Koudstaal, Muniza Rehman, Gerrit Jan Weverling, Jaap Goudsmit, Kanta Subbarao, 2017, Journal of Virology

Genome rearrangement of influenza virus for anti-viral drug screening

Troy C. Sutton, Adebimpe Obadan, Johanna Lavigne, Hongjun Chen, Weizhong Li, Daniel R. Perez, 2014, Virus Research on p. 14-23

News Articles Featuring Troy Sutton

Jun 06, 2024

What to know about the first human case of H5N2 bird flu

H5N2, which was confirmed in a man in Mexico who died, is just one of several kinds of avian influenza viruses. It’s deadly for poultry, but does it pose a significant risk to humans?

Full Article

May 16, 2024

H5N1 virus from 2022 mink outbreak capable of inefficient airborne transmission

Highly pathogenic H5N1 avian influenza was detected in dairy cattle for the first time in the United States in March, with nine states reporting outbreaks by May. While the method of transmission among cattle is currently unknown, new research demonstrates that a related strain of H5N1, which caused an outbreak in farmed mink in 2022, could transmit through the air to a limited number of ferrets.

Full Article

Apr 24, 2024

Dairy Cows Transported Between States Must Now Be Tested for Bird Flu

Since a new form of bird flu arrived in 2022, federal officials have sought to reassure Americans that the threat to the public remained low.

Full Article

Apr 22, 2024

Bird Flu Is Infecting More Mammals. What Does That Mean for Us?

H5N1, an avian flu virus, has killed tens of thousands of marine mammals, and infiltrated American livestock for the first time. Scientists are working quickly to assess how it is evolving and how much of a risk it poses to humans.

Full Article

Mar 12, 2024

New nasal vaccine platform helps clear COVID-19 infections in an animal model

A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study.

Full Article

Jul 23, 2022

I study coronavirus in a highly secured biosafety lab – here's why I feel safer here than in the world outside

As I dilute the coronavirus to infect cultured cells, I hear the reassuring sound of purified air being blown by my respirator into my breathing space. There are three layers of nitrile and protective materials between me and the virus, and every part of my body is wrapped in protective equipment.

Full Article

Apr 29, 2022

Contagious Bird Flu Presents Low Risk to People After Colorado Case

Avian influenza has killed millions of birds in U.S. and infected one known person

Full Article

Oct 21, 2021

Preparing for potential pandemics is focus of new federal grant to Penn State

Researchers at Penn State have received a grant from the National Institute of Allergy and Infectious Diseases to study H7N9 with a goal of developing new and fundamental knowledge of virus mutations that could indicate the potential for transmissibility in humans. 

Full Article

Jun 22, 2020

This supersafe labs protects researchers as they race to develop a coronavirus vaccine

It's quiet in the laboratory, almost peaceful. But I'm holding live SARS-CoV-2 in my hands and this virus is not to be taken lightly.

Full Article

Jul 02, 2024

Inside a High-Security Virus Lab

Inside the second-most secure type of biosafety lab in the U.S. at Penn State

Full Article