Timothy Jegla

Emphasis Area Representative, Molecular and Evolutionary Genetics; Associate Professor of Biology

Timothy Jegla

Research Summary

Functional evolution of eukaryotic ion channels and evolution of neuronal signaling and cell structure.

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Publication Tags

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Neurons Cnidaria Bilateria Voltage Gated Potassium Channels Voltage Gated Potassium Channel Genes Axons Potassium Channels Animal Electric Potential Electric Potential Difference Channel Gating Ancestry Ctenophora Potassium Channel Ether Cyclic Nucleotides Nervous System Phosphatidylinositols Repolarization Nematostella Vectensis Bilaterian Anthozoa Voltage Gated K+ Channels Cations

Most Recent Publications

A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K<sup>+</sup> channels in animals

Timothy Jegla, Benjamin T. Simonson, J. David Spafford, 2024, Proceedings of the National Academy of Sciences of the United States of America

Functional analysis of ctenophore Shaker K<sup>+</sup> channels: N-type inactivation in the animal roots

Benjamin T. Simonson, Max Jegla, Joseph F. Ryan, Timothy Jegla, 2024, Biophysical Journal on p. 2038-2049

Kv12-encoded K<sup>+</sup> channels drive the day–night switch in the repetitive firing rates of SCN neurons

T Hermanstyne, N Yang, D Granados-Fuentes, X Li, R Mellor, Timothy Jegla, E Herzog, J Nerbonne, 2023, Journal of General Physiology

Genome-Scale Analysis Reveals Extensive Diversification of Voltage-Gated K<sup>+</sup> Channels in Stem Cnidarians

A Lara, B Simonson, J Ryan, Timothy Jegla, 2023, Genome Biology and Evolution

Kv12-Encoded K (+) Channels Drive the Day-Night Switch in the Repetitive Firing Rates of SCN Neurons.

T Hermanstyne, N Yang, D Granados-Fuentes, X Li, R Mellor, Timothy Jegla, E Herzog, J Nerbonne, 2023, bioRxiv : the preprint server for biology

Taxonomy and Evolution of Ion Channels

Timothy Jegla, Benjamin T. Simonson, 2023, on p. 1-14

External cd<sup>2+</sup> and protons activate the hyperpolarization-gated k<sup>+</sup> channelkat1atthe voltage sensor

Y Zhou, Sarah Assmann, Timothy Jegla, 2021, Journal of General Physiology

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Michelle C. Stone, Gregory O. Kothe, Melissa M. Rolls, Timothy Jegla, 2020, Journal of Experimental Biology

What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?

Aditya Pisupati, Keith Mickolajczyk, William Hancock, Timothy Jegla, 2020, Proceedings of the National Academy of Sciences of the United States of America on p. 29288-29289

The S6 gate in regulatory Kv6 subunits restricts heteromeric K<sup>+</sup> channel stoichiometry

Aditya Pisupati, Keith Mickolajczyk, William Horton, D van Rossum, A Anishkin, Sree Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, W Hancock, T Jegla, 2018, Journal of General Physiology on p. 1702-1721

Most-Cited Papers

Guard cell sensory systems: recent insights on stomatal responses to light, abscisic acid, and CO<sub>2</sub>

Sarah M. Assmann, Timothy Jegla, 2016, Current Opinion in Plant Biology on p. 157-167

Evolution and structural characteristics of plant voltage-gated K<sup>+</sup> channels

Timothy Jegla, Gregory Busey, Sarah Assmann, 2018, Plant Cell on p. 2898-2909

Neuronal polarity: An evolutionary perspective

Melissa M. Rolls, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 572-580

Functional evolution of Erg potassium channel gating reveals an ancient origin for IKr

Alexandra S. Martinson, Damian B. Van Rossum, Fortunay H. Diatta, Michael J. Layden, Sarah A. Rhodes, Mark Q. Martindale, Timothy Jegla, 2014, Proceedings of the National Academy of Sciences of the United States of America on p. 5712-5717

Major diversification of voltage-gated K<sup>+</sup> channels occurred in ancestral parahoxozoans

Xiaofan Li, Hansi Liu, Jose Chu Luo, Sarah A. Rhodes, Liana M. Trigg, Damian B. Van Rossum, Andriy Anishkin, Fortunay H. Diatta, Jessica K. Sassic, David K. Simmons, Bishoy Kamel, Monica Medina, Mark Q. Martindale, Timothy Jegla, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. E1010-E1019

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Timothy Jegla, Michelle M. Nguyen, Chengye Feng, Daniel J. Goetschius, Esteban Luna, Damian B. van Rossum, Bishoy Kamel, Aditya Pisupati, Elliott S. Milner, Melissa M. Rolls, 2016, PLoS Genetics

Ether-à-go-go family voltage-gated K<sup>+</sup> channels evolved in an ancestral metazoan and functionally diversified in a cnidarian-bilaterian ancestor

Xiaofan Li, Alexandra S. Martinson, Michael J. Layden, Fortunay H. Diatta, Anna P. Sberna, David K. Simmons, Mark Q. Martindale, Timothy J. Jegla, 2015, Journal of Experimental Biology on p. 526-536

Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel

Awani Upadhyay, Aditya Pisupati, Timothy Jegla, Matt Crook, Keith J. Mickolajczyk, Matthew Shorey, Laura E. Rohan, Katherine A. Billings, Melissa M. Rolls, William O. Hancock, Wendy Hanna-Rose, 2016, Nature Communications

Bimodal regulation of an Elk subfamily K<sup>+</sup> channel by phosphatidylinositol 4,5-bisphosphate

Xiaofan Li, Andriy Anishkin, Hansi Liu, Damian B. van Rossum, Sree V. Chintapalli, Jessica K. Sassic, David Gallegos, Kendra Pivaroff-Ward, Timothy Jegla, 2015, Journal of General Physiology on p. 357-374

Functional characterization of Cnidarian HCN channels points to an early evolution of Ih

Emma C. Baker, Michael J. Layden, Damian B. Van Rossum, Bishoy Kamel, Monica Medina, Eboni Simpson, Timothy Jegla, 2015, PLoS One on p. e0142730