Thomas Ma

Professor and Chair of Medicine

Thomas Ma

Huck Affiliations

Most Recent Publications

The complete genome sequence of probiotic Lactobacillus acidophilus ATCC 9224 isolated from sour milk

Anand Kumar, Manmeet Rawat, Yuliya A. Kunde, Karen W. Davenport, Rana Al-Sadi, Patrick Sam Guy Chain, Thomas Y. Ma, 2024, Genome Announcements

Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways

A Ganapathy, K Saha, A Wang, P Arumugam, V Dharmaprakash, Gregory Yochum, Walter Koltun, M Nighot, Gary H. Perdew, T Thompson, Thomas Ma, Prashant Nighot, 2023, Cell Reports on p. 112705

Editorial: Role of matrix metalloproteinases and other inflammatory mediators in the disruption of the intestinal tight junction barrier

Rana Al-Sadi, Raz Abdulqadir, Thomas Ma, 2023, Frontiers in Immunology

Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation

Kushal Saha, Ashwinkumar Subramenium Ganapathy, Alexandra Wang, Priya Arumugam, Nathan Michael Morris, Leonard Harris, Gregory Yochum, Walter Koltun, Gary H. Perdew, Meghali Nighot, Thomas Ma, Prashant Nighot, 2023, Mucosal Immunology

NASHFit: A randomized controlled trial of an exercise training program to reduce clotting risk in patients with NASH

Jonathan G. Stine, Ian R. Schreibman, Alison J. Faust, Jessica Dahmus, Benjamin Stern, Christopher Soriano, Gloriany Rivas, Breianna Hummer, Scot R. Kimball, Nate R. Geyer, Vernon M. Chinchilli, Rohit Loomba, Kathryn Schmitz, Christopher Sciamanna, Cindy Strine, Rachel Wentzel, Sara Marlin, Chris Sica, Jeff Vesek, Elaine Eyster, Lawrence Sinoway, Kathy Bentz, Nancy Handley, Brenda Hershey Fell, Shirlynn Mottilla, Christine Christ, Susan George, Terry Novchich, Megan Beyer, Kofi Clarke, Tiffany Myers, Martha Glading-Steinruck, Karen Krok, Thomas Ma, Thomas Riley, Elizabeth Thompson, Heather Tressler, James Broach, Trang Doan, Sue Patrick, Syndi Reed, Chris Hamilton, Kristin Slavoski, Deborah Tregea, 2022, Hepatology on p. 172-185

IL-1β and the Intestinal Epithelial Tight Junction Barrier

Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology

Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis

Meghali Nighot, Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Eliseo F. Castillo, Alyssa Gregory, Steven Shapiro, Thomas Ma, Prashant Nighot, 2021, Journal of Crohn's and Colitis on p. 1751-1765

Bifidobacterium bifidum enhances the intestinal epithelial tight junction barrier and protects against intestinal inflammation by targeting the toll-like receptor-2 pathway in an nf-κb-independent manner

Rana Al-Sadi, V Dharmaprakash, Prashant Nighot, S Guo, Meghali Nighot, T Do, Thomas Ma, 2021, International Journal of Molecular Sciences

Lactobacillus acidophilus Induces a Strain-specific and Toll-Like Receptor 2–Dependent Enhancement of Intestinal Epithelial Tight Junction Barrier and Protection Against Intestinal Inflammation

Rana Al-Sadi, Prashant Nighot, Meghali Nighot, Mohammad Haque, Manmeet Rawat, Thomas Y. Ma, 2021, American Journal of Pathology on p. 872-884

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation

Rana Al-Sadi, Jessica Engers, Mohammad Haque, Steven King, Deemah Al-Omari, Thomas Y. Ma, 2021, PLoS One

Most-Cited Papers

Lipopolysaccharide regulation of intestinal tight junction permeability is mediated by TLR4 signal transduction pathway activation of FAK and MyD88

Shuhong Guo, Meghali Nighot, Rana Al-Sadi, Tarik Alhmoud, Prashant Nighot, Thomas Ma, 2015, Journal of Immunology on p. 4999-5010

Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway

Rana Al-Sadi, Dongmei Ye, Michel Boivin, Shuhong Guo, Mariam Hashimi, Lisa Ereifej, Thomas Y. Ma, 2014, PLoS One

IL-1β and the Intestinal Epithelial Tight Junction Barrier

Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma, 2021, Frontiers in Immunology

Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation

Prashant K. Nighot, Chien An Andy Hu, Thomas Y. Ma, 2015, Journal of Biological Chemistry on p. 7234-7246

Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression

Meghali Nighot, Rana Al-Sadi, Shuhong Guo, Manmeet Rawat, Prashant Nighot, Martin D. Watterson, Thomas Y. Ma, 2017, American Journal of Pathology on p. 2698-2710

TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

Rana Al-Sadi, Shuhong Guo, Dongmei Ye, Manmeet Rawat, Thomas Y. Ma, 2016, American Journal of Pathology on p. 1151-1165

IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA

M Rawat, K Rawat, Walter Koltun, Meghali Nighot, G Yochum, Rana Al-Sadi, Y Gupta, D Viszwapriya, Gregory Yochum, Thomas Y. Ma, 2020, Gastroenterology on p. 1375-1389

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis

Prashant Nighot, Rana Al-Sadi, Manmeet Rawat, Shuhong Guo, D. Martin Watterson, Thomas Ma, 2015, American Journal of Physiology on p. G988-G997

Intestinal barrier dysfunction in human necrotizing enterocolitis

Sarah A. Moore, Prashant Nighot, Cynthia Reyes, Manmeet Rawat, Jason McKee, David Lemon, Joshua Hanson, Thomas Y. Ma, 2016, Journal of Pediatric Surgery on p. 1907-1913

Lipopolysaccharide-Induced Increase in Intestinal Permeability Is Mediated by TAK-1 Activation of IKK and MLCK/MYLK Gene

Meghali Nighot, Manmeet Rawat, Rana Al-Sadi, Eliseo F. Castillo, Prashant Nighot, Thomas Y. Ma, 2019, American Journal of Pathology on p. 797-812