Thomas Gould
Jean Phillips Shibley Professor and Department Head of Biobehavioral Health

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219 Biobehavioral Health
University Park, PA - tug70@psu.edu
- 814-863-7256
Research Summary
Using genetic, pharmacological, behavioral, and molecular biological techniques to study the neurobiology of learning and memory and the effects of addiction on it.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Neuroscience Institute
- Center for Molecular Investigation of Neurological Disorders
- Center for Brain, Behavior, and Cognition
- Center for Neurotechnology in Mental Health Research
Links
Most Recent Publications
Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice
Laurel R. Seemiller, Lisa R. Goldberg, Aswathy Sebastian, Sue Rutherford Siegel, Craig Praul, Dana Zeid, Istvan Albert, Jacob Beierle, Camron D. Bryant, Thomas J. Gould, 2024, Alcohol, Clinical and Experimental Research on p. 2022-2034
Age is associated with altered locomotor and hypothermic response to acute nicotine
Thomas Gould, 2024, Behavioural Pharmacology on p. 60-69
Behavioral and genetic architecture of fear conditioning and related phenotypes
D. Zeid, L. R. Seemiller, D. A. Wagstaff, T. J. Gould, 2023, Communications in behavioral biology. Part A: [Original articles]
Adolescent intermittent alcohol exposure produces strain-specific cross-sensitization to nicotine and other behavioral adaptations in adulthood in C57BL/6J and DBA/2J mice
Laurel R. Seemiller, Prescilla Garcia-Trevizo, Carlos Novoa, Lisa R. Goldberg, Samantha Murray, Thomas J. Gould, 2023, Pharmacology Biochemistry and Behavior
Epigenetic and long-term effects of nicotine on biology, behavior, and health
Thomas J. Gould, 2023, Pharmacological Research
Chronic nicotine exposure alters sperm small RNA content in C57BL/6J mouse model
Dana Zeid, Thomas J. Gould, 2023, Developmental Psychobiology
Interstrain differences in adolescent fear conditioning after acute alcohol exposure
Laurel R. Seemiller, Lisa R. Goldberg, Prescilla Garcia-Trevizo, Thomas J. Gould, 2023, Journal of Electrophysiological Techniques on p. 35-44
Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains
L Seemiller, L Goldberg, P Smith, J Dennis, A Patterson, Thomas J. Gould, 2022, Neuropharmacology on p. 109279
Genetic influences impacting nicotine use and abuse during adolescence: Insights from human and rodent studies
Lisa R. Goldberg, Thomas J. Gould, 2022, Journal of Electrophysiological Techniques on p. 24-38
Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood
Laurel Seemiller, Sheree Logue, Thomas J. Gould, 2022, Pharmacology Biochemistry and Behavior on p. 173429
Most-Cited Papers
Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: Contributions to development and maintenance of addiction
Munir Kutlu, Thomas J. Gould, 2016, Learning and Memory on p. 515-533
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
James C. Glasbey, Dmitri Nepogodiev, Joana F.F. Simoes, Omar Omar, Elizabeth Li, Mary L. Venn, Mohammad K.Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G. Edwards, Jonathan P. Evans, Marco Fiore, Jose Flavio Videria, Samuel J. Ford, Ian Ganly, Ewen A. Griffiths, Rohan R. Gujjuri, Angelos G. Kolias, Haytham M.A. Kaafarani, Ana Minaya-Bravo, Siobhan C. McKay, Helen M. Mohan, Keith J. Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J. Smart, Grant D. Stewart, Sudha Sundar, Raghavan Vidya, Aneel A. Bhangu, C. Allemand, L. Boccalatte, M. Figari, M. Lamm, J. Larrañaga, C. Marchitelli, F. Noll, D. Odetto, M. Perrotta, J. Saadi, L. Zamora, C. Alurralde, E. L. Caram, D. Eskinazi, J. P. Mendoza, M. Usandivaras, R. Badra, A. Esteban, 2021, Journal of Clinical Oncology on p. 66-78
Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products
Lucinda England, Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, Dorothy Hatsukami, Frances Jensen, Denise Kandel, Bruce Lanphear, Frances Leslie, James Pauly, Jenae Neiderhiser, Mark Rubinstein, Theodore Slotkin, Eliot Spindel, Laura Stroud, Lauren Wakschlag, 2017, Neuroscience and Biobehavioral Reviews on p. 176-189
Negative affective states and cognitive impairments in nicotine dependence
F. Scott Hall, Andre Der-Avakian, Thomas J. Gould, Athina Markou, Mohammed Shoaib, Jared W. Young, 2015, Neuroscience and Biobehavioral Reviews on p. 168-185
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Munir Gunes Kutlu, Thomas J. Gould, 2015, Biochemical Pharmacology on p. 498-511
NAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives
Vinay Parikh, Munir Gunes Kutlu, Thomas J. Gould, 2016, Schizophrenia Research on p. 1-15
Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function
Lisa R. Goldberg, Thomas J. Gould, 2019, European Journal of Neuroscience on p. 2453-2466
Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory
Munir Gunes Kutlu, Thomas J. Gould, 2016, Physiology and Behavior on p. 162-171
Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse
Erica Holliday, Thomas J. Gould, 2016, Neuroscience and Biobehavioral Reviews on p. 173-184
Nicotine Addiction and Psychiatric Disorders
Munir Gunes Kutlu, Vinay Parikh, Thomas J. Gould, 2015, International review of neurobiology on p. 171-208
News Articles Featuring Thomas Gould
Feb 18, 2025
Young adults may be more vulnerable to nicotine addiction than the middle aged
People in their late teens and early 20s may be more sensitive to nicotine and more susceptible to nicotine addiction than middle aged adults, according to a new study in mice from researchers in the Penn State Department of Biobehavioral Health.
Full Article
Nov 09, 2021
Penn State launches Center for Neurotechnology in Mental Health Research
Penn State is launching a University-wide center to bridge fundamental research to understand the brain and mind with potential clinical applications for diagnosing and treating mental health disorders.
Full Article