Seth Bordenstein
Director of the Microbiome Center; Huck Chair in Microbiome Sciences; Professor of Biology and Entomology
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W251 Millennium Science Complex
University Park, PA - srb6251@psu.edu
Research Summary
The evolutionary and genetic principles that shape symbiotic interactions between animals, microbes, and viruses and the major applications of these interactions to human health.
Huck Affiliations
- One Health Microbiome Center
- Molecular, Cellular, and Integrative Biosciences
- Bioinformatics and Genomics
Links
Publication Tags
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Microbiota Microbiome Animals Symbiosis Gastrointestinal Microbiome Wolbachia Microorganisms Biological Sciences Glucose Wasps Nationalities And Ethnic Groups Fibrosis History Molecular Cluster Intestinal Microorganisms Viruses Metabolic Weight Diet Coevolution Genes Genome Vocabulary Flow ObesityMost Recent Publications
Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality
Rupinder Kaur, Angelina McGarry, J. Dylan Shropshire, Brittany A. Leigh, Seth R. Bordenstein, 2024, Science on p. 1111-1117
The mechanism of cytoplasmic incompatibility is conserved in Wolbachia-bearing Aedes aegypti mosquitoes deployed for arbovirus control
Rupinder Kaur, Cole J. Meier, Elizabeth A. McGraw, Julian F. Hillyer, Seth R. Bordenstein, 2024, PLoS Biology
It is time to authenticate the Microbiome Sciences with accredited educational programs and departments
Nichole Ginnan, Seth R. Bordenstein, 2023, PLoS Biology
Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age
Elizabeth K. Mallott, Alexandra R. Sitarik, Leslie D. Leve, Camille Cioffi, Carlos A. Camargo, Kohei Hasegawa, Seth R. Bordenstein, 2023, PLoS Biology
Low Gut Microbial Diversity Augments Estrogen-Driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease
Ozioma S. Chioma, Elizabeth Mallott, Binal Shah-Gandhi, Za Darreyal Wiggins, Madison Langford, Andrew William Lancaster, Alexander Gelbard, Hongmei Wu, Joyce E. Johnson, Lisa Lancaster, Erin M. Wilfong, Leslie J. Crofford, Courtney G. Montgomery, Luc Van Kaer, Seth Bordenstein, Dawn C. Newcomb, Wonder Puryear Drake, 2023, Cells
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
Ozioma S. Chioma, Elizabeth K. Mallott, Austin Chapman, Joseph C. Van Amburg, Hongmei Wu, Binal Shah-Gandhi, Nandita Dey, Marina E. Kirkland, M. Blanca Piazuelo, Joyce Johnson, Gordon R. Bernard, Sobha R. Bodduluri, Steven Davison, Bodduluri Haribabu, Seth R. Bordenstein, Wonder P. Drake, 2022, Communications Biology
Transgenic cytoplasmic incompatibility persists across age and temperature variation in Drosophila melanogaster
Isabella T. Ritchie, Kelly T. Needles, Brittany A. Leigh, Rupinder Kaur, Seth R. Bordenstein, 2022, iScience
Individuality and ethnicity eclipse a short-term dietary intervention in shaping microbiomes and viromes
Junhui Li, Robert H.George Markowitz, Andrew W. Brooks, Elizabeth K. Mallott, Brittany A. Leigh, Timothy Olszewski, Hamid Zare, Minoo Bagheri, Holly M. Smith, Katie A. Friese, Ismail Habibi, William M. Lawrence, Charlie L. Rost, Ákos Lédeczi, Angela M. Eeds, Jane F. Ferguson, Heidi J. Silver, Seth R. Bordenstein, 2022, PLoS Biology
Microbiome-associated human genetic variants impact phenome-wide disease risk
Robert H.George Markowitz, Abigail Leavitt LaBella, Mingjian Shi, Antonis Rokas, John A. Capra, Jane F. Ferguson, Jonathan D. Mosley, Seth R. Bordenstein, 2022, Proceedings of the National Academy of Sciences of the United States of America
A Margulian View of Symbiosis and Speciation: the Nasonia Wasp System
Kara Bell, Seth R. Bordenstein, 2022, Symbiosis on p. 3-10
Most-Cited Papers
Host biology in light of the microbiome: Ten principles of holobionts and hologenomes
Seth R. Bordenstein, Kevin R. Theis, 2015, PLoS Biology
Phylosymbiosis: Relationships and Functional Effects of Microbial Communities across Host Evolutionary History
Andrew W. Brooks, Kevin D. Kohl, Robert M. Brucker, Edward J. van Opstal, Seth R. Bordenstein, 2016, PLoS Biology
Getting the hologenome concept right: An eco-evolutionary framework for hosts and their microbiomes
Kevin R. Theis, Nolwenn M. Dheilly, Jonathan L. Klassen, Robert M. Brucker, John F. Baines, Thomas C.G. Bosch, John F. Cryan, Scott F. Gilbert, Charles J. Goodnight, Elisabeth A. Lloyd, Jan Sapp, Philippe Vandenkoornhuyse, Ilana Zilber-Rosenberg, Eugene Rosenberg, Seth R. Bordenstein, 2016, mSystems
Minimum information about an uncultivated virus genome (MIUVIG)
Simon Roux, Evelien M. Adriaenssens, Bas E. Dutilh, Eugene V. Koonin, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, J. Rodney Brister, Arvind Varsani, Clara Amid, Ramy K. Aziz, Seth R. Bordenstein, Peer Bork, Mya Breitbart, Guy R. Cochrane, Rebecca A. Daly, Christelle Desnues, Melissa B. Duhaime, Joanne B. Emerson, François Enault, Jed A. Fuhrman, Pascal Hingamp, Philip Hugenholtz, Bonnie L. Hurwitz, Natalia N. Ivanova, Jessica M. Labonté, Kyung Bum Lee, Rex R. Malmstrom, Manuel Martinez-Garcia, Ilene Karsch Mizrachi, Hiroyuki Ogata, David Páez-Espino, Marie Agnès Petit, Catherine Putonti, Thomas Rattei, Alejandro Reyes, Francisco Rodriguez-Valera, Karyna Rosario, Lynn Schriml, Frederik Schulz, Grieg F. Steward, Matthew B. Sullivan, Shinichi Sunagawa, Curtis A. Suttle, Ben Temperton, Susannah G. Tringe, Rebecca Vega Thurber, Nicole S. Webster, Katrine L. Whiteson, Steven W. Wilhelm, K. Eric Wommack, Tanja Woyke, Kelly C. Wrighton, Pelin Yilmaz, Takashi Yoshida, Mark J. Young, Natalya Yutin, Lisa Zeigler Allen, Nikos C. Kyrpides, Emiley A. Eloe-Fadrosh, 2019, Nature Biotechnology on p. 29-37
Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility
Daniel LePage, Daniel P. Le Page, Jason Metcalf, Sarah Bordenstein, Jungmin On, Jessamyn Perlmutter, J Shropshire, Emily Layton, Lisa Funkhouser-Jones, John Beckmann, Seth R. Bordenstein, 2017, Nature on p. 243--247
Microbiota and the social brain
Eoin Sherwin, Seth R. Bordenstein, John L. Quinn, Timothy G. Dinan, John F. Cryan, 2019, Science
Gut microbiota diversity across ethnicities in the United States
Andrew W. Brooks, Sambhawa Priya, Ran Blekhman, Seth R. Bordenstein, 2018, PLoS Biology
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Charles Robb Flynn, Vance L. Albaugh, Steven Cai, Joyce Cheung-Flynn, Phillip E. Williams, Robert M. Brucker, Seth R. Bordenstein, Yan Guo, David H. Wasserman, Naji N. Abumrad, 2015, Nature Communications
Living in the endosymbiotic world of Wolbachia: A centennial review
R Kaur, J Shropshire, Karissa Cross, Brittany Leigh, Alexander Mansueto, Victoria Stewart, Sarah Bordenstein, Seth R. Bordenstein, 2021, Cell Host and Microbe on p. 879--893
An introduction to phylosymbiosis
Shen Jean Lim, Seth R. Bordenstein, 2020, Proceedings of the Royal Society B: Biological Sciences
News Articles Featuring Seth Bordenstein
May 14, 2024
'Research Art Collection' showcase in Old Main
The Office of the Senior Vice President for Research at Penn State hosted an open house for the “Research Art Collection” on April 25. The collection showcases the fine balance between art and research through various displays. From cassowary bird scans to bio-manufactured fashion to sustainable architecture, these works are featured in several different dimensional formats, including digital, print and 3D.
Full Article
Mar 08, 2024
Virus hijacking insect sperm causes brutal sterility, find scientists
Penn State researchers unveil the tale of Wolbachia and its viral accomplice manipulating insect reproduction
Full Article
Mar 08, 2024
How does a virus hijack insect sperm to control disease vectors and pests?
A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus.
Full Article
Jan 27, 2024
QIAGEN Announces Partnership With Penn State University to Advance Microbiome Sciences
QIAGEN Announces Partnership With Penn State University to Advance Microbiome Sciences
Full Article
Jan 25, 2024
Penn State, QIAGEN announce strategic partnership to advance microbiome sciences
Penn State, known for innovations in interdisciplinary research, and QIAGEN LLC, a leader in sample-to-insight solutions, have signed a memorandum of understanding (MOU) to foster advancements in microbiome sciences
Full Article
Jan 25, 2024
QIAGEN announces partnership with Penn State University to advance microbiome sciences
Qiagen to provide instruments and solutions for shared research and education facility at the One Health Microbiome Center to support faculty and students
Full Article
Jan 25, 2024
QIAGEN announces partnership with Penn State University to advance microbiome sciences
QIAGEN announced a first-in-kind collaboration with Penn State University to create a shared research and education facility for the fast-developing microbiome sciences
Full Article
Jan 25, 2024
Qiagen partners with Penn State to advance microbiome sciences
QIAGEN announced a first-in-kind collaboration with Penn State University to create a shared research and education facility for the fast-developing microbiome sciences
Full Article
Jan 25, 2024
Qiagen Announces Partnership With Penn State University To Advance Microbiome Sciences
Qiagen announces partnership with Penn State University to Advance Microbiome Sciences
Full Article
Dec 08, 2023
Penn State researchers propose a path to authenticate the Microbiome Sciences
Penn State's One Health Microbiome Center is taking a lead role in the promotion of Microbiome Sciences as an autonomous discipline, publishing an editorial in the latest issue of PLOS Biology.
Full Article
Dec 07, 2023
Penn State researchers announce new comprehensive -Omics database
A group of Penn State scientists have announced kmerDB, an extensive catalogue of sequence information representing all domains of life.
Full Article
Dec 07, 2023
USDA grant supports reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, US$238,500 grant to establish a graduate training pipeline in reproductive microbiome research
Full Article
Dec 06, 2023
New USDA grant to support graduate reproductive microbiome training program
The USDA NIFA has awarded Penn State a five-year, $238,500 grant to establish a graduate training pipeline in reproductive microbiome research.
Full Article
Oct 08, 2023
Podcast explores impacts of inter-species microbial interactions
Over the past two decades, scientists have discovered that all multicellular life forms on Earth, including human beings, play host to a multitude of microorganisms.
Full Article
Sep 07, 2023
One Health Microbiome Center honors creativity and mentoring with award series
The One Health Microbiome Center (OHMC) below has named eight recipients for its 2023-24 Inaugural Award Series.
Full Article
Aug 22, 2023
One Health Microbiome Center's 2023-24 Interdisciplinary Innovation Fellows
The One Health Microbiome Center (OHMC) in the Huck Institutes of the Life Sciences at Penn State has named five recipients for its 2023-24 Interdisciplinary Innovation Fellowships (IIF) program.
Full Article
Aug 17, 2023
Gut bacteria variation among human social groups emerges by three months of age
Bacteria and other microorganisms that live within the human digestive tract — the gut microbiome — differ with parent-reported race and ethnicity as early as 3 months of age, according to a new study co-led by Penn State.
Full Article
Aug 02, 2023
Penn State faculty member elected to plant pathology society leadership
Carolee Bull, professor of systematic bacteriology and plant pathology in Penn State’s College of Agricultural Sciences, has been elected to the presidential lineage of the American Phytopathological Society (APS).
Full Article
May 15, 2023
Penn State's renamed One Health Microbiome Center affirms broad expertise
The Microbiome Center in the Huck Institutes of the Life Sciences at Penn State has announced its renaming to the One Health Microbiome Center (OHMC), the first center in the world to integrate "One Health" with the microbiome sciences.
Full Article
Mar 27, 2023
Geography Coffee Hour talk to explore microorganisms and their impact on life
Microbes may be tiny, but they play a big role in shaping the world. Seth Bordenstein, Dorothy Foehr Huck and J. Lloyd Huck Endowed Chair in Microbiome Sciences and professor of biology and entomology at Penn State, will offer insights into his research on microbiomes and their impact on the world in his talk, “Why We Look Down (To the Microbes) For Wonder, Impact and Discovery,” on March 31.
Full Article
Mar 07, 2023
Habitat split may impact disease risk in amphibians and other vertebrates
Habitat split is a common event in the environment that occurs when different classes of natural habitats, such as forests and water, are disconnected.
Full Article
Feb 27, 2023
New predictive models developed for bacterial diversity of soils
A new set of quantitative models that incorporates pH into the metabolic theory of ecology (MTE) has been developed by an international team that includes Penn State assistant professor of plant science Francisco Dini-Andreote.
Full Article
Feb 15, 2023
Free film and panel discussion reveals 'invisible' crisis of the microbial world
At 6 p.m. Thursday, March 2, Penn State’s Microbiome Center will present "The Invisible Extinction" — a movie that spotlights the trailblazing work and charismatic personalities of renowned scientists who aim to save the vanishing microbes that are essential for our survival.
Full Article
Dec 22, 2022
2022 Top 10 Most Popular Microbiome Center News Articles
The stories that made the year in 2022 for the Penn State Microbiome Center
Full Article
Sep 13, 2022
Microbiome Center announces inaugural Interdisciplinary Innovation Fellows
The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.
Full Article