Scott Lindner

Associate Professor of Biochemistry & Molecular Biology, Co-Director, Center for Malaria Research

Scott Lindner

Research Summary

Our laboratory couples molecular parasitology and structural biology to study the malaria parasite (Plasmodium spp.).

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum

Hui Min, Xiaoying Liang, Chengqi Wang, Junling Qin, Rachasak Boonhok, Azhar Muneer, Awtum M. Brashear, Xiaolian Li, Allen M. Minns, Swamy Rakesh Adapa, Rays H.Y. Jiang, Gang Ning, Yaming Cao, Scott E. Lindner, Jun Miao, Liwang Cui, 2024, Nature Communications

CD4 T Cell–Derived IL-21 Is Critical for Sustaining Plasmodium Infection–Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential

Jordan T. Johnson, Fionna A. Surette, Graham R. Ausdal, Manan Shah, Allen M. Minns, Scott E. Lindner, Ryan A. Zander, Noah S. Butler, 2024, Journal of Immunology on p. 1467-1478

Intranasal SARS-CoV-2 RBD decorated nanoparticle vaccine enhances viral clearance in the Syrian hamster model

Devanshi R. Patel, Allen M. Minns, Derek G. Sim, Cassandra J. Field, Abigail E. Kerr, Talia A. Heinly, Erin H. Luley, Randall M. Rossi, Carol M. Bator, Ibrahim M. Moustafa, Elizabeth B. Norton, Susan L. Hafenstein, Scott E. Lindner, Troy C. Sutton, 2024, Microbiology spectrum

Long-read genome assembly and gene model annotations for the rodent malaria parasite Plasmodium yoelii 17XNL

Mitchell J. Godin, Aswathy Sebastian, Istvan Albert, Scott E. Lindner, 2023, Journal of Biological Chemistry

Ribosome heterogeneity and specialization of Plasmodium parasites

James P. McGee, Jean Paul Armache, Scott E. Lindner, 2023, PLoS Pathogens

Comparative proteomics of vesicles essential for the egress of Plasmodium falciparum gametocytes from red blood cells

Juliane Sassmannshausen, Sandra Bennink, Ute Distler, Juliane Küchenhoff, Allen M. Minns, Scott E. Lindner, Paul Christian Burda, Stefan Tenzer, Tim W. Gilberger, Gabriele Pradel, 2023, Molecular Microbiology

Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites

Rebecca L. Clements, Alexander A. Morano, Francesca M. Navarro, James P. McGee, Esrah W. Du, Vincent A. Streva, Scott E. Lindner, Jeffrey D. Dvorin, 2022, Proceedings of the National Academy of Sciences of the United States of America

Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum

Ian M. Lamb, Kelly T. Rios, Anurag Shukla, Avantika I. Ahiya, Joanne Morrisey, Joshua C. Mell, Scott E. Lindner, Michael W. Mather, Akhil B. Vaidya, 2022, PLoS One

Direct type I interferon signaling in hepatocytes controls malaria

Camila Marques-da-Silva, Kristen Peissig, Michael P. Walker, Justine Shiau, Carson Bowers, Dennis E. Kyle, Rahul Vijay, Scott E. Lindner, Samarchith P. Kurup, 2022, Cell Reports

Standard Selection Treatments with Sulfadiazine Limit Plasmodium yoelii Host-to-Vector Transmission

Kelly T. Rios, Taylor M. Dickson, Scott E. Lindner, 2022, mSphere

Most-Cited Papers

Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice

Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe, 2015, Cell Host and Microbe on p. 526-535

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

Kristian E. Swearingen, Scott E. Lindner, Lirong Shi, Melanie J. Shears, Anke Harupa, Christine S. Hopp, Ashley M. Vaughan, Timothy A. Springer, Robert L. Moritz, Stefan H.I. Kappe, Photini Sinnis, 2016, PLoS Pathogens

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner, Kristian E. Swearingen, Melanie J. Shears, Michael P. Walker, Erin N. Vrana, Kevin J. Hart, Allen M. Minns, Photini Sinnis, Robert L. Moritz, Stefan H.I. Kappe, 2019, Nature Communications

Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites

Kristian E. Swearingen, Scott E. Lindner, Erika L. Flannery, Ashley M. Vaughan, Robert D. Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L. Moritz, Stefan H.I. Kappe, Jetsumon Sattabongkot, Sebastian A. Mikolajczak, 2017, PLoS Neglected Tropical Diseases

A bioinformatic survey of RNA-binding proteins in Plasmodium

BP Niranjan Reddy, Sony Shrestha, Kevin J. Hart, Xiaoying Liang, Karen Kemirembe, Liwang Cui, Scott E. Lindner, 2015, BMC Genomics

Translational regulation during stage transitions in malaria parasites

Liwang Cui, Scott Lindner, Jun Miao, 2015, Annals of the New York Academy of Sciences on p. 1-9

Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development

Scott E. Lindner, Mark J. Sartain, Kiera Hayes, Anke Harupa, Robert L. Moritz, Stefan H.I. Kappe, Ashley M. Vaughan, 2014, Molecular Microbiology on p. 679-693

Th1-like Plasmodium-Specific Memory CD4<sup>+</sup> T Cells Support Humoral Immunity

Ryan A. Zander, Rahul Vijay, Angela D. Pack, Jenna J. Guthmiller, Amy C. Graham, Scott E. Lindner, Ashley M. Vaughan, Stefan H.I. Kappe, Noah S. Butler, 2017, Cell Reports on p. 1839-1852

Cutting back malaria: CRISPR/Cas9 genome editing of Plasmodium

Marcus C.S. Lee, Scott E. Lindner, Jose Juan Lopez-Rubio, Manuel Llinás, 2019, Briefings in Functional Genomics and Proteomics on p. 281-289

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

Ivo Muller, Aaron R. Jex, Stefan H.I. Kappe, Sebastian A. Mikolajczak, Jetsumon Sattabongkot, Rapatbhorn Patrapuvich, Scott Lindner, Erika L. Flannery, Cristian Koepfli, Brendan Ansell, Anita Lerch, Samantha J. Emery-Corbin, Sarah Charnaud, Jeffrey Smith, Nicolas Merrienne, Kristian E. Swearingen, Robert L. Moritz, Michaela Petter, Michael F. Duffy, Vorada Chuenchob, 2019, International Journal for Parasitology on p. 501-513

News Articles Featuring Scott Lindner

Apr 15, 2024

Huck Leadership Fellows selected for 2024-25

For the 2024-2025 academic year, Huck Institutes of the Life Sciences has appointed Associate Professor of Biomedical Engineering Scott Medina, Professor of Statistics Lingzhou Xue, and Associate Professor of Surgery Dino Ravnic to be Huck Leadership Fellows.

Full Article

Mar 12, 2024

New nasal vaccine platform helps clear COVID-19 infections in an animal model

A newly developed intranasal vaccine candidate helps to clear COVID-19 infections more quickly than controls in pre-clinical testing, according to a recent study.

Full Article

Jun 26, 2023

Neela Yennawar and Scott Lindner selected as 2023 Huck Leadership Fellows

Launched in 2022, the Huck Leadership Fellows Program was developed for faculty members seeking to sharpen their leadership skills with an opportunity for exposure to senior leadership within the interdisciplinary research unit.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency-use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new Penn State-led study.

Full Article

Feb 25, 2021

Study finds short window for donating convalescent plasma to COVID-19 patients

The optimal timeframe for donating convalescent plasma for use in COVID-19 immunotherapy, which was given emergency use authorization by the Food and Drug Administration in August 2020, is within 60 days of the onset of symptoms, according to a new study. The research also reveals that the ideal convalescent plasma donor is a recovered COVID-19 patient who is older than 30 and whose illness had been severe.

Full Article

Oct 31, 2019

Malaria parasite lives on the edge

The parasite that causes malaria expresses genes that code for the proteins it will need in later life stages, using two separate schemes to prevent these proteins from actually being made until they are needed, according to new research.

Full Article

Jan 31, 2019

Male birth control for the malaria parasite

Full Article