Ruobo Zhou

Assistant Professor of Chemistry

305 Chemistry
University Park, PA
rkz5110@psu.edu

Bio & Links
Publications

Research Summary

Quantitatively and functionally understanding the compartmentalization and spatiotemporal organization of protein-protein and protein-RNA interactions involved in fundamental cell functions as well as in cancer and neurodegenerative diseases.

Huck Graduate Students

Yuan Tao

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Integrative and Biomedical Physiology

Center for Cellular Dynamics

Bioinformatics and Genomics

Neuroscience

Neuroscience Institute

Most Recent Publications

Watching biomolecules stride in real time

Jinyu Fei, Ruobo Zhou, 2023, Science on p. 986-987

Proteomic and functional analyses of the periodic membrane skeleton in neurons

Ruobo Zhou, Boran Han, Roberta Nowak, Yunzhe Lu, Evan Heller, Chenglong Xia, Athar Chishti, Velia Fowler, Xiaowei Zhuang, 2022, Nature Communications

Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons

Ruobo Zhou, Boran Han, Chenglong Xia, Xiaowei Zhuang, 2019, Science on p. 929-934

βiI-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport

Damaris N. Lorenzo, Alexandra Badea, Ruobo Zhou, Peter J. Mohler, Xiaowei Zhuang, Vann Bennett, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 15686-15695

Junction resolving enzymes use multivalency to keep the Holliday junction dynamic

Ruobo Zhou, Olivia Yang, Anne Cécile Déclais, Hyeonseok Jin, Gwang Hyeon Gwon, Alasdair D.J. Freeman, Yunje Cho, David M.J. Lilley, Taekjip Ha, 2019, Nature Chemical Biology on p. 269-275

Visualizing and discovering cellular structures with super-resolution microscopy

Yaron M. Sigal, Ruobo Zhou, Xiaowei Zhuang, 2018, Science on p. 880-887

Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

Boran Han, Ruobo Zhou, Chenglong Xia, Xiaowei Zhuang, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. E6678-E6685

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A. Carrasco, Peri T. Kurshan, Jonathan E. Farley, David J. Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R. Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, Xiaowei Zhuang, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 6029-6034

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells

Chong Wang, Boran Han, Ruobo Zhou, Xiaowei Zhuang, 2016, Cell on p. 990-1001

Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing

Michael D. Brenner, Ruobo Zhou, Daniel E. Conway, Luca Lanzano, Enrico Gratton, Martin A. Schwartz, Taekjip Ha, 2016, Nano Letters on p. 2096-2102

Most-Cited Papers

Visualizing and discovering cellular structures with super-resolution microscopy

Yaron M. Sigal, Ruobo Zhou, Xiaowei Zhuang, 2018, Science on p. 880-887

Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells

Chong Wang, Boran Han, Ruobo Zhou, Xiaowei Zhuang, 2016, Cell on p. 990-1001

Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility

Thuy T.M. Ngo, Qiucen Zhang, Ruobo Zhou, Jaya G. Yodh, Taekjip Ha, 2015, Cell on p. 1135-1144

Developmental mechanism of the periodic membrane skeleton in axons

Guisheng Zhong, Jiang He, Ruobo Zhou, Damaris Lorenzo, Hazen P. Babcock, Vann Bennett, Xiaowei Zhuang, 2014, eLife

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

Ruobo Zhou, Jichuan Zhang, Matthew L. Bochman, Virginia A. Zakian, Taekjip Ha, 2014, eLife