Pak Kin Wong
Professor of Biomedical Engineering, Mechanical Engineering, and Surgery
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516 Chemical and Biomedical Engineering
University Park, PA - pxw28@psu.edu
- 814-863-5267
Most Recent Publications
Precision single cell analysis to characterize host dependent antimicrobial response heterogeneity in physiological medium
Ryuichiro Abe, Jyong Huei Lee, Siew Mei Chin, Nikhil Ram-Mohan, Kristel C. Tjandra, April M. Bobenchik, Kathleen E. Mach, Joseph C. Liao, Pak Kin Wong, Samuel Yang, 2025, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 714-728
Nano-Biosensors for mRNA-Based Cell Sorting Using Intracellular Markers at the Early Stage of Cell Reprogramming
Yang Song, Jennifer Soto, Xiao Lin, Tyler Hoffman, Erin Hu, Ninghao Zhu, Jana Zarubova, Yifan Wu, Jing Tian, Pak Kin Wong, Song Li, 2025, Advanced Functional Materials
Translating microbiota analysis for clinical applications
Jyong-Huei Lee, Siew Mei Chin, Kathleen Mach, April Bobenchik, Jospeh Liao, Samuel Yang, Pak Wong, 2024, Nature Reviews Bioengineering
Rapid Microbial Profiling through Multimodal Biosensors for Transversal Analysis
Jyong Huei Lee, Siew Mei Chin, Dennis C. Chan, Joseph C. Liao, Samuel Yang, Nanying Zhang, Pak Kin Wong, 2024, Analytical Chemistry
Growth independent morphometric machine learning workflow for single-cell antimicrobial susceptibility testing of Klebsiella pneumoniae to meropenem
Kristel Tjandra, Nikhil Ram-Mohan, Manuel Roshardt, Elizabeth Zudock, Zhaoman Qu, Kathlenn Mach, Okyaz Eminaga, Joseph Liao, Samuel Yang, Pak Wong, 2024, Frontiers in Imaging
Single-cell pathogen diagnostics for combating antibiotic resistance
Hui Li, Kuangwen Hsieh, Pak Kin Wong, Kathleen E. Mach, Joseph C. Liao, Tza Huei Wang, 2023, Nature Reviews Methods Primers
A sticky-end probe biosensor for homogeneous detection of transcription factor binding activity
Joao Paulo Pera Mendes, Ninghao Zhu, Pak Kin Wong, 2023, SLAS Technology on p. 345-350
Long noncoding RNA MALAT1 is dynamically regulated in leader cells during collective cancer invasion
Ninghao Zhu, Mona Ahmed, Yanlin Li, Joseph C. Liao, Pak Kin Wong, 2023, Proceedings of the National Academy of Sciences of the United States of America
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Yang Song, Jennifer Soto, Binru Chen, Tyler Hoffman, Weikang Zhao, Ninghao Zhu, Qin Peng, Longwei Liu, Chau Ly, Pak Kin Wong, Yingxiao Wang, Amy C. Rowat, Siavash K. Kurdistani, Song Li, 2022, Nature Materials on p. 1191-1199
Optimizing locked nucleic acid modification in double-stranded biosensors for live single cell analysis
Samuel A. Vilchez Mercedes, Ian Eder, Mona Ahmed, Ninghao Zhu, Pak Kin Wong, 2022, The Analyst on p. 722-733
Most-Cited Papers
P62 links autophagy and Nrf2 signaling
Tao Jiang, Bryan Harder, Montserrat Rojo De La Vega, Pak K. Wong, Eli Chapman, Donna D. Zhang, 2015, Free Radical Biology and Medicine on p. 199-204
An essential role of NRF2 in diabetic wound healing
Min Long, Montserrat Rojo De La Vega, Qing Wen, Manish Bharara, Tao Jiang, Rui Zhang, Shiwen Zhou, Pak K. Wong, Georg T. Wondrak, Hongting Zheng, Donna D. Zhang, 2016, Diabetes on p. 780-793
Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing
Hui Li, Peter Torab, Kathleen E. Mach, Christine Surrette, Matthew R. England, David W. Craft, Neal J. Thomas, Joseph C. Liao, Chris Puleo, Pak Kin Wong, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 10270-10279
NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
Federico Bocci, Satyendra C. Tripathi, Samuel A. Vilchez Mercedes, Jason T. George, Julian P. Casabar, Pak Kin Wong, Samir M. Hanash, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly, 2019, Integrative Biology (United Kingdom) on p. 251-263
Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration
Reza Riahi, Jian Sun, Shue Wang, Min Long, Donna D. Zhang, Pak Kin Wong, 2015, Nature Communications
Viscoelastic solid-repellent coatings for extreme water saving and global sanitation
Jing Wang, Lin Wang, Nan Sun, Nan Sun, Ross Tierney, Ross Tierney, Hui Li, Hui Li, Margo Corsetti, Margo Corsetti, Leon Williams, Pak Kin Wong, Leon Williams, Pak Kin Wong, Tak Sing Wong, 2019, Nature Sustainability on p. 1097-1105
Decoding leader cells in collective cancer invasion
Samuel A. Vilchez Mercedes, Federico Bocci, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly, Pak Kin Wong, 2021, Nature Reviews Cancer on p. 592-604
Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?
Tongde Wu, Bryan G. Harder, Pak K. Wong, Julie E. Lang, Donna D. Zhang, 2015, Molecular Carcinogenesis on p. 1494-1502
Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality
Christopher T. Pappas, Rachel M. Mayfield, Christine Henderson, Nima Jamilpour, Cathleen Cover, Zachary Hernandez, Kirk R. Hutchinson, Miensheng Chu, Ki Hwan Nam, Jose M. Valdez, Pak Kin Wong, Henk L. Granzier, Carol C. Gregorio, 2015, Proceedings of the National Academy of Sciences of the United States of America on p. 13573-13578
A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
Tao Shen, Tao Jiang, Min Long, Jun Chen, Dong Mei Ren, Pak Kin Wong, Eli Chapman, Bo Zhou, Donna D. Zhang, 2015, Antioxidants and Redox Signaling on p. 651-664
News Articles Featuring Pak Kin Wong
Dec 09, 2024
The stories that defined 2024 for the One Health Microbiome Center at Penn State
The One Health Microbiome Center has grown, and 2024’s most popular articles below highlight the determination and innovative research by Center members in the gut microbiome, nutritional sciences, food science and agriculture, in addition to headlines featuring partnerships and internships paving the way for future success.
Full Article
May 21, 2024
Urine Tests Could Be 'Enormous Step' in Diagnosing Cancer
The next frontier in cancer detection could be the humble urine test. Emerging science suggests that the body's "liquid gold" could be particularly useful for liquid biopsies, offering a convenient, pain-free, and cost-effective way to spot otherwise hard-to-detect cancers.
Full Article
Mar 25, 2024
Listen to your gut: Using microbiota analysis for precision health care
The human body harbors approximately 30 trillion microbes, known collectively as the microbiota. These microorganisms influence various bodily functions, including digestion and metabolism to immune response, according to Pak Kin Wong.
Full Article
Dec 03, 2018
These new tweezers let scientists do biopsies on living cells
Like a tiny game of ‘Operation,’ the tool can extract DNA and other cell parts
Full Article