Pak Kin Wong
Professor of Biomedical Engineering, Mechanical Engineering, and Surgery
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516 Chemical and Biomedical Engineering
University Park, PA - pxw28@psu.edu
- 814-863-5267
Most Recent Publications
Single-cell pathogen diagnostics for combating antibiotic resistance
Hui Li, Kuangwen Hsieh, Pak Kin Wong, Kathleen E. Mach, Joseph C. Liao, Tza Huei Wang, 2023, Nature Reviews Methods Primers
A sticky-end probe biosensor for homogeneous detection of transcription factor binding activity
Joao Paulo Pera Mendes, Ninghao Zhu, Pak Kin Wong, 2023, SLAS Technology on p. 345-350
Long noncoding RNA MALAT1 is dynamically regulated in leader cells during collective cancer invasion
Ninghao Zhu, Mona Ahmed, Yanlin Li, Joseph C. Liao, Pak Kin Wong, 2023, Proceedings of the National Academy of Sciences of the United States of America
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Yang Song, Jennifer Soto, Binru Chen, Tyler Hoffman, Weikang Zhao, Ninghao Zhu, Qin Peng, Longwei Liu, Chau Ly, Pak Kin Wong, Yingxiao Wang, Amy C. Rowat, Siavash K. Kurdistani, Song Li, 2022, Nature Materials on p. 1191-1199
Optimizing locked nucleic acid modification in double-stranded biosensors for live single cell analysis
Samuel A. Vilchez Mercedes, Ian Eder, Mona Ahmed, Ninghao Zhu, Pak Kin Wong, 2022, The Analyst on p. 722-733
Diagnosis of Bloodstream Infections: An Evolution of Technologies towards Accurate and Rapid Identification and Antibiotic Susceptibility Testing
Kristel C. Tjandra, Nikhil Ram-Mohan, Ryuichiro Abe, Marjan M. Hashemi, Jyong Huei Lee, Siew Mei Chin, Manuel A. Roshardt, Joseph C. Liao, Pak Wong, Samuel Yang, 2022, Antibiotics on p. 25
A reconfigurable microfluidic building block platform for high-throughput nonhormonal contraceptive screening
Jyong-Huei Lee, Carl Van Der Linden, Francisco Diaz, Pak Kin Wong, 2022, Lab on a Chip - Miniaturisation for Chemistry and Biology on p. 2531--2539
Chemical design of self-propelled Janus droplets
Caleb Meredith, Darrell Velegol, Alexander Castonguay, Alexander Castonguay, Yu Chiu, Yu-Jen Chiu, Allan Brooks, Allan Brooks, Pepijn Moerman, Pepijn Moerman, Peter Torab, Pak Kin Wong, Peter Torab, Ayusman Sen, PakKin Wong, Ayusman Sen, Lauren Zarzar, 2022, Matter on p. 616-633
A transparent ultrasound on-chip platform enables high-throughput cell stimulation and simultaneous high-resolution optical imaging
Haoyang Chen, Ninghao Zhu, Ryan Biskowitz, Jinyun Liu, Cheri Deng, Pak Kin Wong, Sri Rajasekhar Kothapalli, 2022,
Nrf2 Modulates the Hybrid Epithelial/Mesenchymal Phenotype and Notch Signaling During Collective Cancer Migration
Samuel A. Vilchez Mercedes, Federico Bocci, Mona Ahmed, Ian Eder, Ninghao Zhu, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly, Pak Wong, 2022, Frontiers in Molecular Biosciences on p. 19
Most-Cited Papers
P62 links autophagy and Nrf2 signaling
Tao Jiang, Bryan Harder, Montserrat Rojo De La Vega, Pak K. Wong, Eli Chapman, Donna D. Zhang, 2015, Free Radical Biology and Medicine on p. 199-204
Advances and challenges in biosensor-based diagnosis of infectious diseases
Mandy Ly Sin, Kathleen E. Mach, Pak Kin Wong, Joseph C. Liao, 2014, Expert Review of Molecular Diagnostics on p. 225-244
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
Tongde Wu, Fei Zhao, Beixue Gao, Can Tan, Naoko Yagishita, Toshihiro Nakajima, Pak K. Wong, Eli Chapman, Deyu Fang, Donna D. Zhang, 2014, Genes and Development on p. 708-722
Oncogenic KRAS confers chemoresistance by upregulating NRF2
Shasha Tao, Shue Wang, Seyed Javad Moghaddam, Aikseng Ooi, Eli Chapman, Pak K. Wong, Donna D. Zhang, 2014, Cancer Research on p. 7430-7441
An essential role of NRF2 in diabetic wound healing
Min Long, Montserrat Rojo De La Vega, Qing Wen, Manish Bharara, Tao Jiang, Rui Zhang, Shiwen Zhou, Pak K. Wong, Georg T. Wondrak, Hongting Zheng, Donna D. Zhang, 2016, Diabetes on p. 780-793
Adaptable microfluidic system for single-cell pathogen classification and antimicrobial susceptibility testing
Hui Li, Peter Torab, Kathleen E. Mach, Christine Surrette, Matthew R. England, David W. Craft, Neal J. Thomas, Joseph C. Liao, Chris Puleo, Pak Kin Wong, 2019, Proceedings of the National Academy of Sciences of the United States of America on p. 10270-10279
Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration
Reza Riahi, Jian Sun, Shue Wang, Min Long, Donna D. Zhang, Pak Kin Wong, 2015, Nature Communications
NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
Federico Bocci, Satyendra C. Tripathi, Samuel A. Vilchez Mercedes, Jason T. George, Julian P. Casabar, Pak Kin Wong, Samir M. Hanash, Herbert Levine, José N. Onuchic, Mohit Kumar Jolly, 2019, Integrative Biology (United Kingdom) on p. 251-263
Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?
Tongde Wu, Bryan G. Harder, Pak K. Wong, Julie E. Lang, Donna D. Zhang, 2015, Molecular Carcinogenesis on p. 1494-1502
Viscoelastic solid-repellent coatings for extreme water saving and global sanitation
Jing Wang, Lin Wang, Nan Sun, Nan Sun, Ross Tierney, Ross Tierney, Hui Li, Hui Li, Margo Corsetti, Margo Corsetti, Leon Williams, Pak Kin Wong, Leon Williams, Pak Kin Wong, Tak Sing Wong, 2019, Nature Sustainability on p. 1097-1105
News Articles Featuring Pak Kin Wong
May 21, 2024
Urine Tests Could Be 'Enormous Step' in Diagnosing Cancer
The next frontier in cancer detection could be the humble urine test. Emerging science suggests that the body's "liquid gold" could be particularly useful for liquid biopsies, offering a convenient, pain-free, and cost-effective way to spot otherwise hard-to-detect cancers.
Full Article
Mar 25, 2024
Listen to your gut: Using microbiota analysis for precision health care
The human body harbors approximately 30 trillion microbes, known collectively as the microbiota. These microorganisms influence various bodily functions, including digestion and metabolism to immune response, according to Pak Kin Wong.
Full Article
Dec 03, 2018
These new tweezers let scientists do biopsies on living cells
Like a tiny game of ‘Operation,’ the tool can extract DNA and other cell parts
Full Article