Nanyin Zhang

Director of the Center for Neurotechnology in Mental Health Research; Huck Chair in Brain Imaging; Professor of Bioengineering

Nanyin Zhang

Research Summary

Investigating the pathophysiology of brain disorders using neuroimaging, behavioral and optogenetic methods.

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Genetic influences of resting-state neural networks: a twin study

Y Fu, Z Ma, C Hamilton, Z Liang, X Hou, X Ma, X Hu, H Meng, Q He, W Deng, Y Wang, L Zhao, T Li, Nanyin Zhang, Human Brain Mapping on p. 3959–3972

An open database of resting-state fMRI in awake rats

Yikang Liu, Pablo Perez, Zilu Ma, Zhiwei Ma, David Dopfel, Samuel Cramer, Wenyu Tu, Nanyin Zhang, NeuroImage on p. 1170942

A splitting mind: imbalanced internal and external worlds in schizophrenia

M Li, W Deng, Z He, Q Wang, C Huang, L Jiang, Q Gong, D Ziedonis, J King, X Ma, Nanyin Zhang, Tao Li, on p. 145-153

Relationship of mindful awareness to neural processing of anger stimuli and impact of mindfulness training

A Lee, D Gansler, Nanyin Zhang, M Jerram, J King, C Fulwiler, Psychiatry Research: Neuroimaging on p. 22-28

Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System

Haoyang Chen, Shubham Mirg, Prameth Gaddale, Sumit Agrawal, Menghan Li, Van Nguyen, Tianbao Xu, Qiong Li, Jinyun Liu, Wenyu Tu, Xiao Liu, Patrick J. Drew, Nanyin Zhang, Bruce J. Gluckman, Sri Rajasekhar Kothapalli, 2024, Advanced Science

Perturbing cortical networks: in vivo electrophysiological consequences of pan-neuronal chemogenetic manipulations using deschloroclozapine

Péter Kovács, Lauren N. Beloate, Nanyin Zhang, 2024, Frontiers in Neuroscience

Sex differences in resting-state functional networks in awake rats

Qiong Li, Nanyin Zhang, 2023, Brain Structure and Function on p. 1411-1423

Author Correction: A consensus protocol for functional connectivity analysis in the rat brain (Nature Neuroscience, (2023), 26, 4, (673-681), 10.1038/s41593-023-01286-8)

Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Célestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvořáková, Claudia Falfán-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibañez, Clément M. Garin, Eveline Gelderman, Carla E.M. Golden, Chao C.G. Guo, Marloes J.A.G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra López-Castro, Xavier López-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M.P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickaël Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Pérez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A.B. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-García, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T.B. van Hout, Roberta Vertullo, Benjamin Vidal, Roël M. Vrooman, Victora X. Wang, Isabel Wank, David J.G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Jürgen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J.P.C. Becq, Erwin L.A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jérémie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Gröhn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean Baptiste Langlois, Jason P. Lerch, Monica A. López-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Muñoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldán, Wen Ju Pan, Roberto A. Prado-Alcalá, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W.J. Scheenen, Noam Shemesh, Yen Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie Van Der Linden, Annette van der Toorn, Geralda A.F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess, 2023, Nature Neuroscience on p. 1127-1128

A consensus protocol for functional connectivity analysis in the rat brain

Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barrière, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Célestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvořáková, Claudia Falfán-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibañez, Clément Garin, Eveline Gelderman, Carla E.M. Golden, Chao C.G. Guo, Marloes J.A.G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra López -Castro, Xavier López-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M.P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickaël Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Pérez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A.B. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-García, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T.B. van Hout, Roberta Vertullo, Benjamin Vidal, Roël M. Vrooman, Victora X. Wang, Isabel Wank, David J.G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Jürgen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J.P.C. Becq, Erwin L.A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jérémie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Gröhn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean Baptiste Langlois, Jason P. Lerch, Monica A. López-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Muñoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldán, Wen Ju Pan, Roberto A. Prado-Alcalá, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W.J. Scheenen, Noam Shemesh, Yen Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie Van Der Linden, Annette van der Toorn, Geralda A.F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess, 2023, Nature Neuroscience on p. 673-681

High-frequency neuronal signal better explains multi-phase BOLD response

Q Zhang, S Cramer, K Turner, Thomas Neuberger, Patrick Drew, Nanyin Zhang, 2023, NeuroImage on p. 119887

Most-Cited Papers

Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal

Yu Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T. Winder, Zhifeng Liang, Lilith Antinori, Patrick J. Drew, Nanyin Zhang, 2017, NeuroImage on p. 382-398

Co-activation patterns in resting-state fMRI signals

Xiao Liu, Nanyin Zhang, Catie Chang, Jeff H. Duyn, 2018, NeuroImage on p. 485-494

Rodent models of post-traumatic stress disorder: behavioral assessment

Alexander Verbitsky, David Dopfel, Nanyin Zhang, 2020, Translational Psychiatry

Dynamic resting state functional connectivity in awake and anesthetized rodents

Zhifeng Liang, Xiao Liu, Nanyin Zhang, 2015, NeuroImage on p. 89-99

Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats

Zhifeng Liang, Glenn D.R. Watson, Kevin D. Alloway, Gangchea Lee, Thomas Neuberger, Nanyin Zhang, 2015, NeuroImage on p. 114-123

A role for the claustrum in salience processing?

Jared B. Smith, Glenn D.R. Watson, Zhifeng Liang, Yikang Liu, Nanyin Zhang, Kevin D. Alloway, 2019, Frontiers in Neuroanatomy

The development and expression of physical nicotine dependence corresponds to structural and functional alterations in the anterior cingulate-precuneus pathway

Wei Huang, Jean A. King, W. W.Sanouri Ursprung, Shaokuan Zheng, Nanyin Zhang, David N. Kennedy, Douglas Ziedonis, Joseph R. DiFranza, 2014, Brain and Behavior on p. 408-417

Dynamic Connectivity Patterns in Conscious and Unconscious Brain

Yuncong Ma, Christina Hamilton, Nanyin Zhang, 2017, Brain Connectivity on p. 1-12

Genetic influences on resting-state functional networks: A twin study

Yixiao Fu, Zhiwei Ma, Christina Hamilton, Zhifeng Liang, Xiao Hou, Xingshun Ma, Xiaomei Hu, Qian He, Wei Deng, Yingcheng Wang, Liansheng Zhao, Huaqing Meng, Tao Li, Nanyin Zhang, 2015, Human Brain Mapping on p. 3959-3972

Neuroplasticity to a single-episode traumatic stress revealed by resting-state fMRI in awake rats

Zhifeng Liang, Jean King, Nanyin Zhang, 2014, NeuroImage on p. 485-491

News Articles Featuring Nanyin Zhang

Nov 08, 2024

Uncharted territory: A Q&A with Nanyin Zhang on mapping brain activity

To understand how different regions of the brain work together, researchers use a method called resting-state functional magnetic resonance imaging (rsfMRI). The method measures brain activity by observing changes in blood flow to different parts of the brain; however, rsfMRI does not explain how these blood flow changes to different brain regions relate to what is happening with the brain’s neurons — cells that send and receive messages in the form of electronic signals.

Full Article

Jan 30, 2024

$4M grant funds project to make robotic prostheses more like biological limbs

Prosthetic hands that incorporate robotics can perform dexterous self-care tasks, but they are often hard to operate, requiring a user’s constant attention with a limited number of hand functions. With a five-year, $4 million U.S. National Science Foundation grant, Penn State researchers aim to make robotic protheses more useful for people living with amputations.

Full Article

Nov 10, 2022

Breathing may measurably modulate neural responses across brain, study finds

Mental health practitioners and meditation gurus have long credited intentional breathing with the ability to induce inner calm, but scientists do not fully understand how the brain is involved in the process.

Full Article

Nov 09, 2021

Penn State launches Center for Neurotechnology in Mental Health Research

Penn State is launching a University-wide center to bridge fundamental research to understand the brain and mind with potential clinical applications for diagnosing and treating mental health disorders.

Full Article

Jul 24, 2020

Researchers to examine relation of dysfunctional brain hubs to mental disorders

The National Institutes of Health has awarded Penn State researchers a $1.85 million grant to develop a new way to test if dysfunctions in certain areas of the brain lead to mental health complications and brain disorders. If successful, the research could lead to better mental health treatments.

Full Article