Lorraine Santy

Associate Chair, Molecular, Cellular, and Integrative Biosciences Graduate Degree Program; Associate Professor of Biochemistry and Molecular Biology

208 Althouse Lab
University Park, PA 16802
She/Her
lcs13@psu.edu
814-863-6813

Bio & Links
Publications

Research Summary

The signals and processes that initiate migration in epithelial cells.

Huck Affiliations

Molecular, Cellular, and Integrative Biosciences

Center for Cellular Dynamics

Publication Tags

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Proteins Recycling Hepatocyte Growth Factor Cytohesin 2 Arf6 Arf1 Gtp Phosphohydrolases Cell Movement Integrins Stiffness Threonine Guanine Nucleotide Exchange Factors Epithelial Cells Cytohesin Chemical Activation Guanosine Triphosphate Cells Acute Kidney Injury Membranes Traction Apoptotic Force Actins Gradient Accelerated Spectroscopy Guanine Nucleotide Exchange Factor

Most Recent Publications

Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement

Emily J. Koubek, Lorraine C. Santy, 2022, Cells

Arf GTPases and their GEFs and GAPS: Concepts and challenges

Elizabeth Sztul, Pei Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schürmann, Ilka Wilhelmi, Marielle E. Yohe, Richard A. Kahn, 2019, Molecular Biology of the Cell on p. 1249-1271

A traction force threshold signifies metastatic phenotypic change in multicellular epithelia

Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210

ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation

Emily J. Koubek, Lorraine C. Santy, 2018, Small GTPases on p. 242-259

ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment

Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular Biology of the Cell on p. 4265-4279

The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice

Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological Reports

The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association

Kevin G. Hiester, Lorraine C. Santy, 2013, PLoS One

The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration

Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in Immunology

Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling

Seung Ja Oh, Lorraine C. Santy, 2012, The Quarterly journal of microscopical science on p. 3195-3201

Most-Cited Papers