Lorraine Santy
Associate Chair, Molecular, Cellular, and Integrative Biosciences Graduate Degree Program; Associate Professor of Biochemistry and Molecular Biology
-
208 Althouse Lab
University Park, PA 16802 - She/Her
- lcs13@psu.edu
- 814-863-6813
Research Summary
The signals and processes that initiate migration in epithelial cells.
Huck Affiliations
Links
Most Recent Publications
Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement
Emily J. Koubek, Lorraine C. Santy, 2022, Cells
Arf GTPases and their GEFs and GAPS: Concepts and challenges
Elizabeth Sztul, Pei Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schürmann, Ilka Wilhelmi, Marielle E. Yohe, Richard A. Kahn, 2019, Molecular Biology of the Cell on p. 1249-1271
A traction force threshold signifies metastatic phenotypic change in multicellular epithelia
Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210
ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation
Emily J. Koubek, Lorraine C. Santy, 2018, Small GTPases on p. 242-259
ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment
Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular Biology of the Cell on p. 4265-4279
The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice
Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological Reports
The cytohesin coiled-coil domain interacts with threonine 276 to control membrane association
Kevin G. Hiester, Lorraine C. Santy, 2013, PLoS One
The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration
Myriam A. Attar, Lorraine C. Santy, 2013, BMC Cell Biology
PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures
Marc Leshner, Shu Wang, Carrie Lewis, Han Zheng, Xiangyun Amy Chen, Lorraine Santy, Yanming Wang, 2012, Frontiers in Immunology
Phosphoinositide specificity determines which cytohesins regulate β1 integrin recycling
Seung Ja Oh, Lorraine C. Santy, 2012, The Quarterly journal of microscopical science on p. 3195-3201
Most-Cited Papers
Arf GTPases and their GEFs and GAPS: Concepts and challenges
Elizabeth Sztul, Pei Wen Chen, James E. Casanova, Jacqueline Cherfils, Joel B. Dacks, David G. Lambright, Fang Jen S. Lee, Paul A. Randazzo, Lorraine C. Santy, Annette Schürmann, Ilka Wilhelmi, Marielle E. Yohe, Richard A. Kahn, 2019, Molecular Biology of the Cell on p. 1249-1271
A traction force threshold signifies metastatic phenotypic change in multicellular epithelia
Yao Zhang, Xuechen Shi, Tiankai Zhao, Changjin Huang, Qiong Wei, Xin Tang, Lorraine C. Santy, M. Taher A. Saif, Sulin Zhang, 2019, Soft Matter on p. 7203-7210
The cytohesin guanosine exchange factors (GEFs) are required to promote hgf-mediated renal recovery after acute kidney injury (AKI) in mice
Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Physiological Reports
ARF-GEF cytohesin-2/ARNO regulates R-Ras and α5-integrin recycling through an EHD1-positive compartment
Joseph C. Salem, Marta M. Reviriego-Mendoza, Lorraine C. Santy, 2015, Molecular Biology of the Cell on p. 4265-4279
ARF1 and ARF6 regulate recycling of GRASP/Tamalin and the Rac1-GEF Dock180 during HGF-induced Rac1 activation
Emily J. Koubek, Lorraine C. Santy, 2018, Small GTPases on p. 242-259
Actin Up: An Overview of the Rac GEF Dock1/Dock180 and Its Role in Cytoskeleton Rearrangement
Emily J. Koubek, Lorraine C. Santy, 2022, Cells