Lacy Alexander
Professor of Kinesiology
-
113 Noll Lab
University Park, - lma191@psu.edu
- 814-867-1781
Research Summary
Dr. Alexander utilizes in vivo and in vitro approaches using the human cutaneous circulation to examine the underlying signaling mechanisms mediating microvascular dysfunction with primary human aging, hypercholesterolemia, and essential hypertension.
Huck Affiliations
Most Recent Publications
Financial Hardship and Age-Related Decrements in Kidney Function among Black and White Adults in the Midlife in the United States Study
Agus Surachman, Meera Harhay, Alexis R. Santos, Jonathan Daw, Lacy M. Alexander, David M. Almeida, Christopher L. Coe, 2024, Psychosomatic Medicine on p. 431-442
Quantifying the Implications of Humidity and Temperature on Heat Stress Exposure of Construction Workers: A Worker-Centric Physiological Sensing Approach
Amit Ojha, Houtan Jebelli, Lacy Alexander, Jayson R. Loeffert, 2024, on p. 196-205
Letter to the Editor in response to: Microvascular endothelial function following the cessation of long-term oral contraceptive pill use: A case report
Nathalie V. Kirby, Nina S. Stachenfeld, Lacy M. Alexander, 2023, Experimental Physiology on p. 1092-1094
Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
Auni C. Williams, Virginia G. Content, Nathalie V. Kirby, Lacy M. Alexander, 2023, Journal of Visualized Experiments
Back to the future
Lacy M. Alexander, 2023, Journal of Applied Physiology on p. 1-2
Nitric oxide-mediated cutaneous microvascular function is not altered in middle-aged-to-older adults following mild SARS-CoV-2 infection: A pilot study
G Dillon, S Wolf, A Williams, W. Larry Kenney, Lacy Alexander, 2023, Physiological Reports on p. e15704
Science and cycling: Creating meaningful connections
Lacy M. Alexander, 2023, Physiologist on p. 40
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Gabrielle A. Dillon, Anna E. Stanhewicz, Corinna Serviente, Valerie A. Flores, Nina Stachenfeld, Lacy M. Alexander, 2022, Microvascular Research
Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function
S Wolf, G Dillon, Lacy Alexander, Nina G. Jablonski, W. Larry Kenney, 2022, American Journal of Physiology on p. 490-498
Short-term salicylate treatment improves microvascular endotheliumdependent dilation in young adults with major depressive disorder
Jody L. Greaney, Erika F.H. Saunders, Lacy M. Alexander, 2022, American Journal of Physiology on p. H880-H889
Most-Cited Papers
Heat waves aging and human cardiovascular health
W. Larry Kenney, Daniel H. Craighead, Lacy M. Alexander, 2014, Medicine and Science in Sports and Exercise on p. 1891-1899
Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women with Major Depressive Disorder
Jody L. Greaney, Erika F.H. Saunders, Lakshmi Santhanam, Lacy M. Alexander, 2019, Circulation Research on p. 564-574
Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults
Jody L. Greaney, Jessica L. Kutz, Sean W. Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 902-909
Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia
Anna E. Stanhewicz, Sandeep Jandu, Lakshmi Santhanam, Lacy M. Alexander, 2017, Hypertension on p. 382-389
Sympathetic regulation during thermal stress in human aging and disease
Jody L. Greaney, W. Larry Kenney, Lacy M. Alexander, 2015, Journal of the Autonomic Nervous System on p. 81-90
Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans
Tanner C. Mcnamara, Jeremy T. Keen, Grant H. Simmons, Lacy M. Alexander, Brett J. Wong, 2014, Journal of Physiology on p. 5317-5326
Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature
Jessica L. Kutz, Jody L. Greaney, Lakshmi Santhanam, Lacy M. Alexander, 2015, Journal of Physiology on p. 2121-2129
Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms
Anna E. Stanhewicz, Lacy M. Alexander, W. Larry Kenney, 2015, Clinical Science on p. 159-167
INOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat
Naoto Fujii, Robert D. Meade, Lacy M. Alexander, Pegah Akbari, Imane Foudil-Bey, Jeffrey C. Louie, Pierre Boulay, Glen P. Kenny, 2016, Journal of Applied Physiology on p. 318-327
Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow
David A. Low, Helen Jones, N. Tim Cable, Lacy M. Alexander, W. Larry Kenney, 2020, European Journal of Applied Physiology
News Articles Featuring Lacy Alexander
Oct 30, 2024
Physiology Conference to feature celebration marking 50 years of Noll Lab research
Penn State and the American Physiological Society will celebrate a half century of research at the groundbreaking Noll Laboratory, welcoming attendees of the Integrative Physiology of Exercise (IPE) conference with commemorative “Noll@50” events centered around the landmark facility.
Full Article
Mar 21, 2023
Kinesiology professor to edit Journal of Applied Physiology
Lacy Alexander, professor of kinesiology at Penn State, has been named editor-in-chief of the Journal of Applied Physiology, a leading scientific journal in the study of how organs, tissues, cells and molecular components of humans and animals respond to stressors.
Full Article
Jul 23, 2022
People with endometriosis might be at higher risk for stroke
According to a study published Thursday in Stroke, a journal of the American Stroke Association (part of the American Heart Association), people with endometriosis — a common gynecological condition marked by pain in the pelvis and back, painful and heavy periods, and infertility — were at a 34 percent greater risk of developing a stroke compared to their non-endometriosis peers.
Full Article