Keefe Manning
Professor of Biomedical Engineering and Surgery
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530 Chemical and Biomedical Engineering
University Park, PA - kbm10@psu.edu
- 814-863-6318
Research Summary
Understanding the native cardiovascular system fluid mechanics; understanding the diseased cardiovascular system fluid mechanics, and the impact that cardiovascular prosthetics generate during and post implantation.
Huck Graduate Students
Huck Affiliations
Links
Most Recent Publications
GPVI-mediated thrombus stabilization of shear-induced platelet aggregates in a microfluidic stenosis
C Watson, Christopher Siedlecki, Keefe B. Manning, 2025, Biophysical Journal on p. 158-171
A hyper-viscoelastic uniaxial characterization of collagenous embolus analogs in acute ischemic stroke
Jose L. Monclova, Daniel J. Walsh, Terrell Barraclough, Madelyn E. Hummel, Ian Goetz, Vikas Kannojiya, Francesco Costanzo, Scott Simon, Keefe B. Manning, 2024, Journal of the Mechanical Behavior of Biomedical Materials
Fluid Dynamic Study of the Penn State Pediatric Total Artificial Heart
C Kubicki, E Raich, Peter Selinskry, P Selinsky, S Ponnaluri, William Weiss, Steven Deutsch, William Weiss, Keefe B. Manning, 2024, Journal of Biomechanical Engineering on p. 101007
Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Connor Watson, Hicham Saaid, Vijay Vedula, Jessica Cardenas, Peter Henke, Franck Nicoud, Xiao Yu, Beverley Hunt, Keefe Manning, 2024, Ann Biomed Eng on p. 467-486
Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Connor Watson, Hicham Saaid, Vijay Vedula, Jessica C. Cardenas, Peter K. Henke, Franck Nicoud, Xiao Yun Xu, Beverley J. Hunt, Keefe B. Manning, 2024, Annals of Biomedical Engineering on p. 467-486
Influence of Hematocrit Level and Integrin α<sub>IIb</sub>β<sub>III</sub> Function on vWF-Mediated Platelet Adhesion and Shear-Induced Platelet Aggregation in a Sudden Expansion
Connor T. Watson, Shane C. Ward, Stefano A. Rizzo, Alberto Redaelli, Keefe B. Manning, 2024, Cellular and Molecular Bioengineering on p. 49-65
Fluid Dynamic and in Vitro Blood Study to Understand Catheter-Related Thrombosis
Hannah Palahnuk, Boyang Su, Thaddeus Harbaugh, Cleo Gesenberg, Shouhao Zhou, Elias Rizk, Jonathan Bernstein, S. Will Hazard, Keefe B. Manning, 2024, Cardiovascular Engineering and Technology
Numerical Study on the Impact of Central Venous Catheter Placement on Blood Flow in the Cavo-Atrial Junction
Boyang Su, Hannah Palahnuk, Thaddeus Harbaugh, Elias Rizk, W Hazard, Sprague Hazard, Angel Chan, J Bernstein, Jonathan Weinsaft, K Manning, J Weinsaft, Keefe Manning, 2024, Annals of Biomedical Engineering on p. 1378-1392
Characterizing thrombus adhesion strength on common cardiovascular device materials
Vikas Kannojiya, Sara E. Almasy, Jose L. Monclova, Jerry Contreras, Francesco Costanzo, Keefe B. Manning, 2024, Frontiers in Bioengineering and Biotechnology
Current Approaches and Methods to Understand Acute Ischemic Stroke Treatment Using Aspiration Thrombectomy
Priyanka Patki, Scott Simon, Francesco Costanzo, Keefe B. Manning, 2024, Cardiovascular Engineering and Technology
Most-Cited Papers
FDA Benchmark Medical Device Flow Models for CFD Validation
Richard A. Malinauskas, Prasanna Hariharan, Steven W. Day, Luke H. Herbertson, Martin Buesen, Ulrich Steinseifer, Kenneth I. Aycock, Bryan C. Good, Steven Deutsch, Keefe B. Manning, Brent A. Craven, 2017, ASAIO Journal on p. 150-160
Development of a computational model for macroscopic predictions of device-induced thrombosis
Joshua O. Taylor, Richard S. Meyer, Steven Deutsch, Keefe B. Manning, 2016, Biomechanics and Modeling in Mechanobiology on p. 1713-1731
Hemodynamics in a Pediatric Ascending Aorta Using a Viscoelastic Pediatric Blood Model
Bryan C. Good, Steven Deutsch, Keefe B. Manning, 2016, Annals of Biomedical Engineering on p. 1019-1035
The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava
Kenneth I. Aycock, Robert Lee Campbell, Frank Lynch, Keefe B. Manning, Brent A. Craven, 2016, Annals of Biomedical Engineering on p. 3568-3582
Science for surgeons: Understanding pump thrombogenesis in continuous-flow left ventricular assist devices
Andreas R. De Biasi, Keefe B. Manning, Arash Salemi, 2015, Journal of Thoracic and Cardiovascular Surgery on p. 667-673
Inter-Laboratory Characterization of the Velocity Field in the FDA Blood Pump Model Using Particle Image Velocimetry (PIV)
Prasanna Hariharan, Kenneth I. Aycock, Martin Buesen, Steven W. Day, Bryan C. Good, Luke H. Herbertson, Ulrich Steinseifer, Keefe B. Manning, Brent A. Craven, Richard A. Malinauskas, 2018, Cardiovascular Engineering and Technology on p. 623-640
A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters
Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Brent A. Craven, 2017, Biomechanics and Modeling in Mechanobiology on p. 851-869
Computational modeling of the Food and Drug Administration’s benchmark centrifugal blood pump
Bryan C. Good, Keefe B. Manning, 2020, Artificial Organs on p. E263-E276
Steady Flow in a Patient-Averaged Inferior Vena Cava—Part I: Particle Image Velocimetry Measurements at Rest and Exercise Conditions
Maureen B. Gallagher, Kenneth I. Aycock, Brent A. Craven, Keefe B. Manning, 2018, Cardiovascular Engineering and Technology on p. 641-653
An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC
Elisabetta Tedaldi, Chiara Montanari, Kenneth I. Aycock, Francesco Sturla, Alberto Redaelli, Keefe B. Manning, 2018, Journal of Biomedical Engineering on p. 44-55
News Articles Featuring Keefe Manning
Dec 09, 2024
Biomedical engineering professor elected American Heart Association Fellow
Keefe Manning, Penn State professor of biomedical engineering with a courtesy appointment as a professor of surgery, was elected fellow of the American Heart Association by the association's stroke council.
Full Article
Jan 05, 2023
Controlled, localized delivery of blood thinner may improve blood clot treatment
Heparin has long been used as a blood thinner, or anticoagulant, for patients with blood clotting disorders or after surgery to prevent complications. But the medication remains difficult to dose correctly, potentially leading to overdosing or underdosing.
Full Article
Sep 23, 2019
Penn State researchers receive grant to explore novel method of anticoagulation
Two Penn State biomedical engineering faculty members have received a two-year, $200,000 grant from the American Heart Association (AHA) to explore potential solutions to thrombosis, or blood clot formation, a prevalent issue with blood-contacting medical devices such as heart valves, blood pumps and cardiac stents.
Full Article