Justin Brown

Professor of Biomedical Engineering

Justin Brown

Research Summary

Understanding the fundamental mechanisms by which biomaterial interfaces alter the proliferation, migration and differentiation of mesenchymal stem cells, and application of these principles in the intelligent design of biomaterial scaffolds that facilitate generation or regeneration of musculoskeletal tissues

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Osteointegration of Ti Bone Implants: A Study on How Surface Parameters Control the Foreign Body Response

Andrea Mesa-Restrepo, Elizabeth Byers, Justin L. Brown, Juan Ramirez, Jean Paul Allain, Viviana M. Posada, 2024, ACS Biomaterials Science and Engineering on p. 4662-4681

Characterization of the mechanical state of human mesenchymal stem cells on micro- or nano-textured Ti6Al4V surfaces

Elizabeth Byers, Michelle Gallagher, James Sugar, Justin Brown, 2023, Canadian Journal of Surgery on p. S50

Endothelial Cell Selectivity to Nanoparticles Depends on Mechanical Phenotype

Pouria Fattahi, Yin Ting Yeh, Tiankai Zhao, Mousa Younesi, Changjin Huang, Mauricio Terrones, M Terrones Maldonado, S Zheng, Justin L. Brown, Dan Dongeun Huh, Sulin Zhang, Peter Butler, 2023, Advanced Materials Interfaces on p. 13

Evaluation of focal adhesion mediated subcellular curvature sensing in response to engineered extracellular matrix

Daniel T. Bowers, Mary Elizabeth McCulloch, Justin L. Brown, 2023, Biointerphases

Spatial and depth mapping of nascent mineralization on Ti6Al4V surfaces demonstrating hierarchical macro- micro- nanoscale surface features

Vraj Shah, Michelle Gallagher, Aaron Cheung, Justin Brown, 2022, Canadian Journal of Surgery on p. S130-S131

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast migration velocity

Daniel Bowers, Justin Brown, 2022, Integrative Biology on p. 295-308

The Pull of Tissue Engineering: A STEM Outreach Program with a Modular Cyclic Stretch Device to Engage High Scholl

Tugba Ozdemir, Erdal Senocak, Gene Gerber, Secil Tayhan, Justin Brown, 2022, Biomedical Engineering Education on p. 9

Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity

Daniel T. Bowers, Justin L. Brown, 2021, Integrative Biology (United Kingdom) on p. 295-308

3D-Printed Bioreactor Enhances Potential for Tendon Tissue Engineering

Brittany L. Banik, Justin L. Brown, 2020, Regenerative Engineering and Translational Medicine on p. 419-428

Bone Tissue Engineering

Justin Brown, Cato Laurencin, 2020, on p. 1373-1388

Most-Cited Papers

Polymeric nanoparticles: The future of nanomedicine

Brittany L. Banik, Pouria Fattahi, Justin L. Brown, 2016, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology on p. 271-299

Human mesenchymal stem cell morphology, migration, and differentiation on micro and nano-textured titanium

Emily G. Long, Merve Buluk, Michelle B. Gallagher, Jennifer M. Schneider, Justin L. Brown, 2019, Bioactive Materials on p. 249-255

3D Near-Field Electrospinning of Biomaterial Microfibers with Potential for Blended Microfiber-Cell-Loaded Gel Composite Structures

Pouria Fattahi, Jordan T. Dover, Justin L. Brown, 2017, Advanced healthcare materials

The role of substrate topography on the cellular uptake of nanoparticles

C Huang, T Ozdemir, Li Chong Xu, Peter J. Butler, Christopher A. Siedlecki, Justin L. Brown, Sulin Zhang, 2015, Journal of Biomedical Materials Research - Part B Applied Biomaterials on p. 488-495

Multiscale Poly-(ϵ-caprolactone) Scaffold Mimicking Non-linearity in Tendon Tissue Mechanics

Brittany L. Banik, Gregory S. Lewis, Justin L. Brown, 2016, Regenerative Engineering and Translational Medicine

Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter

A. M. Higgins, B. L. Banik, J. L. Brown, 2015, Integrative Biology (United Kingdom) on p. 229-236

Human mesenchymal stem cell morphology and migration on microtextured titanium

Brittany L. Banik, Thomas R. Riley, Christina J. Platt, Justin L. Brown, 2016, Frontiers in Bioengineering and Biotechnology

Mesenchymal Stem Cell Deformability and Implications for Microvascular Sequestration

Herbert H. Lipowsky, Daniel T. Bowers, Brittany L. Banik, Justin L. Brown, 2018, Annals of Biomedical Engineering on p. 640-654

Bone Tissue Engineering

Justin L. Brown, Cato T. Laurencin, 2020, on p. 1373-1388

Gelatin nanofiber matrices derived from schiff base derivative for tissue engineering applications

Devina Jaiswal, Roshan James, Namdev B. Shelke, Matthew D. Harmon, Justin L. Brown, Fazle Hussain, Sangamesh G. Kumbar, 2015, Journal of Biomedical Nanotechnology on p. 2067-2080