Joyce Jose

Associate Professor of Biochemistry & Molecular Biology

Joyce Jose

Research Summary

Virus-host interactions involved in the pathogenesis of alphaviruses and flaviviruses. Analysis of virus induced structures and cytoskeletal modifications in mammalian host and insect vector using high-resolution live cell imaging and electron microscopy. Viral determinants of neurotropism, encephalitis, transmission and persistence in BSL-3 pathogens.

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Publication Tags

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Viruses Proteins Antiviral Agents Alphavirus Sars Virus Glycoproteins Lipids Lycorine Drug Peptide Hydrolases Sindbis Virus Crystal Structure Membranes Cells Antiviral Drug Protease Inhibitor Active Sites Sitagliptin Assays Proteinases Cytidine Triphosphate Nelfinavir Mesylate Covalent Bond Virus Release Ion Channels

Most Recent Publications

The Dynamic Landscape of Capsid Proteins and Viral RNA Interactions in Flavivirus Genome Packaging and Virus Assembly

Anastazia Jablunovsky, Joyce Jose, 2024, Pathogens

Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein

Anastazia Jablunovsky, Anoop Narayanan, Joyce Jose, 2024, PLoS Neglected Tropical Diseases

Zika virus M protein latches and locks the E protein from transitioning to an immature state after prM cleavage.

Sydney Majowicz, Anoop Narayanan, Ibrahim Moustafa, Carol Bator, Susan Hafenstein, Joyce Jose, 2023, npj Viruses

Requirement of a functional ion channel for Sindbis virus glycoprotein transport, CPV-II formation, and efficient virus budding

Zeinab Elmasri, Vashi Negi, Richard Kuhn, Joyce Jose, 2022, PLoS Pathogens on p. e1010892

Asymmetry in icosahedral viruses

Joyce Jose, Susan L. Hafenstein, 2022, Current Opinion in Virology on p. 101230

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

Anoop Narayanan, Manju Narwal, Sydney Majowicz, Carmine Varricchio, Shay Toner, Carlo Ballotore, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology on p. 169

Structure-based inhibitor design and repurposing clinical drugs to target SARS-CoV-2 proteases

Anoop Narayanan, Shay Toner, Joyce Jose, 2022, Biochemical Society Transactions on p. 151-165

Drugs to limit Zika virus infection and implication for maternal-fetal health

Ankur Kumar, Deepak Kumar, Joyce Jose, Rajanish Giri, Indira U. Mysorekar, 2022, Frontiers in Virology

A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide

Kellan T. Passow, Haley S. Caldwell, Kiet A. Ngo, Jamie J. Arnold, Jamie JArnold, Nicole M. Antczak, Anoop Narayanan, Joyce Jose, Shana J. Sturla, Craig E. Cameron, Alexander Ciota, D Harki, 2021, Journal of Medicinal Chemistry on p. 15429-15439

Alphavirus-induced membrane rearrangements during replication, assembly, and budding

Zeinab Elmasri, Benjamin L. Nasal, Joyce Jose, 2021, Pathogens

Most-Cited Papers

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Thomas Mandel Clausen, Daniel R. Sandoval, Charlotte B. Spliid, Jessica Pihl, Hailee R. Perrett, Chelsea D. Painter, Anoop Narayanan, Sydney A. Majowicz, Elizabeth M. Kwong, Rachael N. McVicar, Bryan E. Thacker, Charles A. Glass, Zhang Yang, Jonathan L. Torres, Gregory J. Golden, Phillip L. Bartels, Ryan N. Porell, Aaron F. Garretson, Logan Laubach, Jared Feldman, Xin Yin, Yuan Pu, Blake M. Hauser, Timothy M. Caradonna, Benjamin P. Kellman, Cameron Martino, Philip L.S.M. Gordts, Sumit K. Chanda, Aaron G. Schmidt, Kamil Godula, Sandra L. Leibel, Joyce Jose, Kevin D. Corbett, Andrew B. Ward, Aaron F. Carlin, Jeffrey D. Esko, 2020, Cell on p. 1043-1057.e15

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system

David L. Akey, W. Clay Brown, Somnath Dutta, Jamie Konwerski, Joyce Jose, Thomas J. Jurkiw, James DelProposto, Craig M. Ogata, Georgios Skiniotis, Richard J. Kuhn, Janet L. Smith, 2014, Science on p. 881-885

A naturally occurring antiviral ribonucleotide encoded by the human genome

Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo, 2018, Nature on p. 610-614

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

Anoop Narayanan, Manju Narwal, Sydney Majowicz, Carmine Varricchio, Shay Toner, Carlo Ballotore, Carlo Ballatore, Andrea Brancale, Katsuhiko S. Murakami, Joyce Jose, 2022, Communications Biology on p. 169

Structure-guided insights on the role of NS1 in flavivirus infection

David L. Akey, W. Clay Brown, Joyce Jose, Richard J. Kuhn, Janet L. Smith, 2015, BioEssays on p. 489-494

Spatial and temporal analysis of alphavirus replication and assembly in mammalian and mosquito cells

Joyce Jose, Aaron B. Taylor, Richard J. Kuhn, 2017, mBio

Locking and blocking the viral landscape of an alphavirus with neutralizing antibodies

Jason Porta, Joyce Jose, John T. Roehrig, Carol D. Blair, Richard J. Kuhn, Michael G. Rossmann, 2014, Journal of Virology on p. 9616-9623

Glycan-dependent chikungunya viral infection divulged by antiviral activity of NAG specific chi-like lectin

Ramanjit Kaur, Neetu, Rajat Mudgal, Joyce Jose, Pravindra Kumar, Shailly Tomar, 2019, Virology on p. 91-98

Identification of a pocket factor that is critical to Zika virus assembly

Nadia M. DiNunno, Daniel J. Goetschius, Anoop Narayanan, Sydney A. Majowicz, Ibrahim Moustafa, Carol M. Bator, Susan L. Hafenstein, Joyce Jose, 2020, Nature Communications

Fluorescent protein-tagged sindbis virus E2 glycoprotein allows single particle analysis of virus budding from live cells

Joyce Jose, Jinghua Tang, Aaron B. Taylor, Timothy S. Baker, Richard J. Kuhn, 2015, Viruses on p. 6182-6199

News Articles Featuring Joyce Jose

Feb 05, 2024

How does Zika virus replicate and transmit from mother to fetus?

In 2015, an outbreak of Zika virus, driven by a heavy rain season and subsequent boom in the virus’s host mosquito population, caused thousands of babies in Brazil to be born with severe birth defects.

Full Article

Feb 25, 2022

Repurposing FDA-approved drugs may help combat COVID-19

Several FDA-approved drugs — including for type 2 diabetes, hepatitis C and HIV — significantly reduce the ability of the Delta variant of SARS-CoV-2 to replicate in human cells, according to new research led by scientists at Penn State. Specifically, the team found that these drugs inhibit certain viral enzymes, called proteases, that are essential for SARS-CoV-2 replication in infected human cells.

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Sep 13, 2021

Eberly’s 2022 Lab Bench to Commercialization grant recipients announced

The Eberly College of Science has chosen faculty members Joyce Jose and Sally Mackenzie to receive its 2022 Lab Bench to Commercialization grants. This competitive program provides funding for researchers in the college, enabling them to enhance the commercial potential of ongoing Penn State research and prepare them to translate their Penn State-owned intellectual property to the marketplace.

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Jul 07, 2021

Fighting COVID with COVID

What if the COVID-19 virus could be used against itself? Researchers at Penn State have designed a proof-of-concept therapeutic that may be able to do just that. The team designed a synthetic defective SARS-CoV-2 virus that is innocuous but interferes with the real virus’ growth, potentially causing the extinction of both the disease-causing virus and the synthetic virus.

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