Joshua Gross

Assistant Professor of Nutrition and Biobehavioral Health

Joshua Gross

Research Summary

Cellular- and transgenic mouse model-based approaches to investigate the molecular mechanisms of G protein-coupled receptor (GPCR) signaling and trafficking in the pathophysiological contexts of obesity, eating disorders, and metabolic disease.

Huck Affiliations

Links

Most Recent Publications

Platelet factors attenuate inflammation and rescue cognition in ageing

Adam B. Schroer, Patrick B. Ventura, Juliana Sucharov, Rhea Misra, M. K.Kirsten Chui, Gregor Bieri, Alana M. Horowitz, Lucas K. Smith, Katriel Encabo, Imelda Tenggara, Julien Couthouis, Joshua D. Gross, June M. Chan, Anthony Luke, Saul A. Villeda, 2023, Nature on p. 1071-1079

Ghrelin receptor signaling in health and disease: a biased view

Joshua D. Gross, Yang Zhou, Lawrence S. Barak, Marc G. Caron, 2023, Trends in Endocrinology and Metabolism on p. 106-118

Establishment of multi-stage intravenous self-administration paradigms in mice

Lauren M. Slosky, Andrea Pires, Yushi Bai, Nicholas B. Clark, Elizabeth R. Hauser, Joshua D. Gross, Fiona Porkka, Yang Zhou, Xiaoxiao Chen, Vladimir M. Pogorelov, Krisztian Toth, William C. Wetsel, Lawrence S. Barak, Marc G. Caron, 2022, Scientific Reports

Discovery of a functionally selective ghrelin receptor (GHSR<sub>1a</sub>) ligand for modulating brain dopamine

J. D. Gross, D. W. Kim, Y. Zhou, D. Jansen, L. M. Slosky, N. B. Clark, C. R. Ray, X. Hu, N. Southall, A. Wang, X. Xu, E. Barnaeva, W. C. Wetsel, M. Ferrer, J. J. Marugan, M. G. Caron, L. S. Barak, K. Toth, 2022, Proceedings of the National Academy of Sciences of the United States of America

Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review

Shane W. Kaski, Allison N. White, Joshua D. Gross, David P. Siderovski, 2021, Anesthesia and Analgesia on p. 406-419

The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21)

Adam B. Schroer, Kayla W. Branyan, Joshua D. Gross, Paul D. Chantler, Adam J. Kimple, Aurelie Vandenbeuch, David P. Siderovski, 2021, Chemical Senses

Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo

Allison N. White, Joshua D. Gross, Shane W. Kaski, Kristen R. Trexler, Kim A. Wix, William C. Wetsel, Steven G. Kinsey, David P. Siderovski, Vincent Setola, 2020, Journal of Psychopharmacology on p. 1393-1407

Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior

Joshua D. Gross, Shane W. Kaski, Karl T. Schmidt, Elizabeth S. Cogan, Kristen M. Boyt, Kim Wix, Adam B. Schroer, Zoe A. McElligott, David P. Siderovski, Vincent Setola, 2019, Neuropsychopharmacology on p. 1728-1741

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

Shane W. Kaski, Allison N. White, Joshua D. Gross, Kristen R. Trexler, Kim Wix, Aubrie A. Harland, Thomas E. Prisinzano, Jeffrey Aubé, Steven G. Kinsey, Terry Kenakin, David P. Siderovski, Vincent Setola, 2019, Journal of Pharmacology and Experimental Therapeutics on p. 487-499

Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice

Kristen R. Trexler, Sara R. Nass, Molly S. Crowe, Joshua D. Gross, Margaret S. Jones, Austin W. McKitrick, David P. Siderovski, Steven G. Kinsey, 2018, Drug and Alcohol Dependence on p. 14-24

Most-Cited Papers

Platelet factors attenuate inflammation and rescue cognition in ageing

Adam B. Schroer, Patrick B. Ventura, Juliana Sucharov, Rhea Misra, M. K.Kirsten Chui, Gregor Bieri, Alana M. Horowitz, Lucas K. Smith, Katriel Encabo, Imelda Tenggara, Julien Couthouis, Joshua D. Gross, June M. Chan, Anthony Luke, Saul A. Villeda, 2023, Nature on p. 1071-1079

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

Shane W. Kaski, Allison N. White, Joshua D. Gross, Kristen R. Trexler, Kim Wix, Aubrie A. Harland, Thomas E. Prisinzano, Jeffrey Aubé, Steven G. Kinsey, Terry Kenakin, David P. Siderovski, Vincent Setola, 2019, Journal of Pharmacology and Experimental Therapeutics on p. 487-499

Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice

Kristen R. Trexler, Sara R. Nass, Molly S. Crowe, Joshua D. Gross, Margaret S. Jones, Austin W. McKitrick, David P. Siderovski, Steven G. Kinsey, 2018, Drug and Alcohol Dependence on p. 14-24

Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review

Shane W. Kaski, Allison N. White, Joshua D. Gross, David P. Siderovski, 2021, Anesthesia and Analgesia on p. 406-419

Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior

Joshua D. Gross, Shane W. Kaski, Karl T. Schmidt, Elizabeth S. Cogan, Kristen M. Boyt, Kim Wix, Adam B. Schroer, Zoe A. McElligott, David P. Siderovski, Vincent Setola, 2019, Neuropsychopharmacology on p. 1728-1741

Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants

Joshua D. Gross, Shane W. Kaski, Adam B. Schroer, Kimberley A. Wix, David P. Siderovski, Vincent Setola, 2018, Journal of Psychopharmacology on p. 191-203

Development of full sweet, umami, and bitter taste responsiveness requires Regulator of G protein Signaling-21 (RGS21)

Adam B. Schroer, Joshua D. Gross, Shane W. Kaski, Kim Wix, David P. Siderovski, Aurelie Vandenbeuch, Vincent Setola, 2018, Chemical Senses on p. 367-378

Ghrelin receptor signaling in health and disease: a biased view

Joshua D. Gross, Yang Zhou, Lawrence S. Barak, Marc G. Caron, 2023, Trends in Endocrinology and Metabolism on p. 106-118

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance

B. J. Gall, A. Wilson, A. B. Schroer, J. D. Gross, P. Stoilov, V. Setola, C. M. Watkins, D. P. Siderovski, 2016, Genes and Immunity on p. 139-147

Discovery of a functionally selective ghrelin receptor (GHSR<sub>1a</sub>) ligand for modulating brain dopamine

J. D. Gross, D. W. Kim, Y. Zhou, D. Jansen, L. M. Slosky, N. B. Clark, C. R. Ray, X. Hu, N. Southall, A. Wang, X. Xu, E. Barnaeva, W. C. Wetsel, M. Ferrer, J. J. Marugan, M. G. Caron, L. S. Barak, K. Toth, 2022, Proceedings of the National Academy of Sciences of the United States of America