Joseph Reese
Professor of Biochemistry and Molecular Biology
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463A North Frear Laboratory
University Park, PA 16802 - jcr8@psu.edu
- 814-865-1976
Research Summary
Gene regulation in cell cycle and DNA damage control; regulation of DNA damage-induced transcription.
Huck Affiliations
Links
Most Recent Publications
New roles for elongation factors in RNA polymerase II ubiquitylation and degradation
Joseph C. Reese, 2023, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
DEF1: Much more than an RNA polymerase degradation factor
Oluwasegun T. Akinniyi, Joseph C. Reese, 2021, DNA Repair
Nucleosome Dynamics during Transcription Elongation
Mai Huynh, Satya Yadav, Joseph C. Reese, Tae Hee Lee, 2020, ACS Chemical Biology on p. 3133-3142
Ccr4–not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII
Haoyang Jiang, Marley Wolgast, Laura M. Beebe, Joseph C. Reese, 2019, Genes and Development on p. 705-717
Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II.
J Lee, J Crickard, Joseph Reese, T Lee, 2019, Methods (San Diego, Calif.) on p. 51-58
Biochemical methods to characterize RNA polymerase II elongation complexes
J. Brooks Crickard, Joseph C. Reese, 2019, ImmunoMethods on p. 70-81
Analysis of RNAPII complexes
Joseph C. Reese, 2019, ImmunoMethods on p. 1-3
Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II
Jaehyoun Lee, J. Brooks Crickard, Joseph C. Reese, Tae Hee Lee, 2019, ImmunoMethods on p. 51-58
Regulation of tRNA synthesis and modification in physiological conditions and disease
Magdalena Boguta, Joseph C. Reese, 2018, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms on p. 283-284
Genome-wide mapping of decay factor-mRNA interactions in yeast identifies nutrient-responsive transcripts as targets of the deadenylase Ccr4
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese, 2018, G3: Genes, Genomes, Genetics on p. 315-330
Most-Cited Papers
The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome
John B. Crickard, Jaehyoun Lee, Tae Hee Lee, Joseph C. Reese, 2017, Nucleic Acids Research on p. 6362-6374
Ccr4-Not and TFIIS function cooperatively to rescue arrested RNA polymerase II
Arnob Dutta, Vinod Babbarwal, Jianhua Fu, Deborah Brunke-Reese, Diane M. Libert, Jonathan Willis, Joseph C. Reese, 2015, Molecular and Cellular Biology on p. 1915-1925
Biochemical analysis of yeast suppressor of Ty 4/5 (Spt4/5) reveals the importance of nucleic acid interactions in the prevention of RNA polymerase II arrest
J. Brooks Crickard, Jianhua Fu, Joseph C. Reese, 2016, Journal of Biological Chemistry on p. 9853-9870
The Rpb4/7 module of RNA polymerase II is required for carbon catabolite repressor protein 4-negative on TATA (Ccr4-Not) complex to promote elongation
Vinod Babbarwal, Jianhua Fu, Joseph C. Reese, 2014, Journal of Biological Chemistry on p. 33125-33130
A highly conserved region within H2B is important for FACT to act on nucleosomes
Suting Zheng, J. Brooks Crickard, Abhinaya Srikanth, Joseph C. Reese, 2014, Molecular and Cellular Biology on p. 303-314
Ccr4–not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII
Haoyang Jiang, Marley Wolgast, Laura M. Beebe, Joseph C. Reese, 2019, Genes and Development on p. 705-717
Genome-wide mapping of decay factor-mRNA interactions in yeast identifies nutrient-responsive transcripts as targets of the deadenylase Ccr4
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese, 2018, G3: Genes, Genomes, Genetics on p. 315-330
Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II
Jaehyoun Lee, J. Brooks Crickard, Joseph C. Reese, Tae Hee Lee, 2019, ImmunoMethods on p. 51-58
Nucleosome Dynamics during Transcription Elongation
Mai Huynh, Satya Yadav, Joseph C. Reese, Tae Hee Lee, 2020, ACS Chemical Biology on p. 3133-3142
Gene expression as a circular process: Cross-talk between transcription and mRNA degradation in eukaryotes; International University of Andalusia (UNIA) Baeza, Spain
Martine A. Collart, Joseph C. Reese, 2014, RNA Biology on p. 320-323
News Articles Featuring Joseph Reese
Jul 23, 2024
$1.7M grant continues support for graduate students studying gene regulation
Renewed support for a training program established at Penn State in 2018 ensures five additional years of funding for graduate students conducting cross-disciplinary studies of the mechanisms controlling where and when genes are used in cells.
Full Article
Feb 14, 2024
Penn State molecular biologist Joseph Reese named distinguished professor
Joseph Reese, professor of biochemistry and molecular biology, has been selected to receive the title of Distinguished Professor of Biochemistry and Molecular Biology
Full Article
Apr 05, 2019
Unjamming the genome after DNA damage
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA.
Full Article