Jordan Bisanz
Assistant Professor of Biochemistry and Molecular Biology
Research Summary
The interface of microbiology and bioinformatics, with approaches including genomics and metabolomics to investigate the interplay of diet, drugs, and the gut microbiome.
Huck Affiliations
Links
Most Recent Publications
A synthetic microbiota designed through meta-analysis provides insight to community function in Clostridioides difficile resistance.
Susan Tian, Min Soo Kim, Jingcheng Zhao, Kerim Heber, Fuhua Hao, D Koslicki, A Patterson, Jordan Bisanz, Cell Host & Microbe
Black raspberry modulates cecal and oral microbiome at the early stage of a dibenzo[def,p]chrysene-induced murine oral cancer model.
Jingcheng Zhao, Y Sun, K Chebn, C Aliaga, Jordan Bisanz, K El-Bayoumy, Cancer Prevention Research
Black Raspberry Modulates Cecal and Oral Microbiomes at the Early Stage of a Dibenzo[def,p]chrysene-Induced Murine Oral Cancer Model
Jingcheng Zhao, Yuan Wan Sun, Kun Ming Chen, Cesar Aliaga, Jordan E. Bisanz, Karam El-Bayoumy, 2025, Cancer Prevention Research on p. 11-21
Multiple mycotoxin exposure assessment through human biomonitoring in an esophageal cancer case-control study in the Arsi-Bale districts of Oromia region of Ethiopia
Girma Mulisa, Roger Pero-Gascon, Valerie McCormack, Jordan E. Bisanz, Fazlur Rahman Talukdar, Tamrat Abebe, Marthe De Boevre, Sarah De Saeger, 2025, International Journal of Hygiene and Environmental Health
High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model
Benjamin Anderson, Diana Sepulveda, Rahul Nachnani, Alonso Cortez-Resendiz, Matthew Coates, Aviauna Beckett, J Bisanz, A Beckett, W Raup-Konsavage, Jordan Bisanz, Joshua Kellogg, Wesley Raup-Konsavage, 2024, Journal of Pharmacology and Experimental Therapeutics on p. 331-341
Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice
Yuan Tian, Bipin Rimal, Jordan E. Bisanz, Wei Gui, Trenton M. Wolfe, Imhoi Koo, Iain Alexander Murray, Shaneice K. Nettleford, Shigetoshi Yokoyama, Fangcong Dong, Sergei Koshkin, K. Sandeep Prabhu, Peter J. Turnbaugh, Seth T. Walk, Gary H. Perdew, Andrew D. Patterson, 2024, Environmental Health Perspectives on p. 87005
Human gut Actinobacteria boost drug absorption by secreting P-glycoprotein ATPase inhibitors
Than S. Kyaw, Chen Zhang, Moriah Sandy, Kai Trepka, Shenwei Zhang, Luis A. Ramirez Hernandez, Lorenzo Ramirez, Janice J.N. Goh, Kristie Yu, Vincent Dimassa, Elizabeth N. Bess, Jacob G. Brockert, Darren S. Dumlao, Jordan E. Bisanz, Peter J. Turnbaugh, 2024, iScience
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
Megan D. McCurry, Gabriel D. D'Agostino, Jasmine T. Walsh, Jordan E. Bisanz, Ines Zalosnik, Xueyang Dong, David J. Morris, Joshua R. Korzenik, Andrea G. Edlow, Emily P. Balskus, Peter J. Turnbaugh, Jun R. Huh, A. Sloan Devlin, 2024, Cell on p. 2952-2968.e13
The Potential of Cannabichromene (CBC) as a Therapeutic Agent
Diana Sepulveda, Kent Vrana, Joshua Kellogg, Jordan Bisanz, Dhimant Desai, Nicholas M. Graziane, Wesley Raup-Konsavage, 2024, Journal of Pharmacology and Experimental Therapeutics on p. 206-213
Microbiome single cell atlases generated with a commercial instrument.
X Li, L Xu, B Demaree, C Noecker, Jordan Bisanz, D Weisgerber, C Modavi, P Turnbaugh, A Abate, 2024, bioRxiv
Most-Cited Papers
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
E Bolyen, J Rideout, M Dillon, N Bokulich, C Abnet, G Al-Ghalith, H Alexander, E Alm, M Arumugam, F Asnicar, Y Bai, Jordan E. Bisanz, K Bittinger, A Brejnrod, C Brislawn, C Brown, B Callahan, A Caraballo-Rodríguez, J Chase, E Cope, R Da Silva, C Diener, P Dorrestein, G Douglas, D Durall, C Duvallet, C Edwardson, M Ernst, M Estaki, J Fouquier, J Gauglitz, S Gibbons, D Gibson, A Gonzalez, K Gorlick, J Guo, B Hillmann, S Holmes, H Holste, C Huttenhower, G Huttley, S Janssen, A Jarmusch, L Jiang, B Kaehler, K Kang, C Keefe, P Keim, S Kelley, D Knights, I Koester, T Kosciolek, J Kreps, Langille MGI, Morgan G.I. Langille, J Lee, R Ley, Y Liu, E Loftfield, C Lozupone, M Maher, C Marotz, B Martin, D McDonald, L McIver, A Melnik, J Metcalf, S Morgan, J Morton, A Naimey, J Navas-Molina, L Nothias, S Orchanian, T Pearson, S Peoples, D Petras, M Preuss, E Pruesse, L Rasmussen, A Rivers, M Robeson, 2nd, Michael S. Robeson, P Rosenthal, N Segata, M Shaffer, A Shiffer, R Sinha, S Song, J Spear, A Swafford, L Thompson, P Torres, P Trinh, A Tripathi, P Turnbaugh, S Ul-Hasan, van der Hooft JJJ, Justin J.J. van der Hooft, F Vargas, Y Vázquez-Baeza, E Vogtmann, M von Hippel, W Walters, Y Wan, M Wang, J Warren, K Weber, Williamson CHD, Charles H.D. Williamson, A Willis, Z Xu, J Zaneveld, Y Zhang, Q Zhu, R Knight, J Caporaso, 2019, Nature Biotechnology on p. 852-857
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Vayu Maini Rekdal, V Maini Rekdal, E Bess, Jordan Bisanz, P Turnbaugh, E Balskus, 2019, Science
Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 (Nature Biotechnology, (2019), 37, 8, (852-857), 10.1038/s41587-019-0209-9)
Evan Bolyen, Jai Ram Rideout, Matthew R. Dillon, Nicholas A. Bokulich, Christian C. Abnet, Gabriel A. Al-Ghalith, Harriet Alexander, Eric J. Alm, Manimozhiyan Arumugam, Francesco Asnicar, Yang Bai, Jordan E. Bisanz, Kyle Bittinger, Asker Brejnrod, Colin J. Brislawn, C. Titus Brown, Benjamin J. Callahan, Andrés Mauricio Caraballo-Rodríguez, John Chase, Emily K. Cope, Ricardo Da Silva, Christian Diener, Pieter C. Dorrestein, Gavin M. Douglas, Daniel M. Durall, Claire Duvallet, Christian F. Edwardson, Madeleine Ernst, Mehrbod Estaki, Jennifer Fouquier, Julia M. Gauglitz, Sean M. Gibbons, Deanna L. Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin Hillmann, Susan Holmes, Hannes Holste, Curtis Huttenhower, Gavin A. Huttley, Stefan Janssen, Alan K. Jarmusch, Lingjing Jiang, Benjamin D. Kaehler, Kyo Bin Kang, Christopher R. Keefe, Paul Keim, Scott T. Kelley, Dan Knights, Irina Koester, Tomasz Kosciolek, Jorden Kreps, Morgan G.I. Langille, Joslynn Lee, Ruth Ley, Yong Xin Liu, Erikka Loftfield, Catherine Lozupone, Massoud Maher, Clarisse Marotz, Bryan D. Martin, Daniel McDonald, Lauren J. McIver, Alexey V. Melnik, Jessica L. Metcalf, Sydney C. Morgan, Jamie T. Morton, Ahmad Turan Naimey, Jose A. Navas-Molina, Louis Felix Nothias, Stephanie B. Orchanian, Talima Pearson, Samuel L. Peoples, Daniel Petras, Mary Lai Preuss, Elmar Pruesse, Lasse Buur Rasmussen, Adam Rivers, Michael S. Robeson, Patrick Rosenthal, Nicola Segata, Michael Shaffer, Arron Shiffer, Rashmi Sinha, Se Jin Song, John R. Spear, Austin D. Swafford, Luke R. Thompson, Pedro J. Torres, Pauline Trinh, Anupriya Tripathi, Peter J. Turnbaugh, Sabah Ul-Hasan, Justin J.J. van der Hooft, Fernando Vargas, Yoshiki Vázquez-Baeza, Emily Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C. Weber, Charles H.D. Williamson, Amy D. Willis, Zhenjiang Zech Xu, Jesse R. Zaneveld, Yilong Zhang, Qiyun Zhu, Rob Knight, J. Gregory Caporaso, 2019, Nature Biotechnology on p. 1091
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
S Collins, Jonathan Stine, Jordan E. Bisanz, C. Denise Okafor, D Okafor, Andrew Patterson, 2022, Nature Reviews Microbiology on p. 236-247
Human gut bacteria produce Τ<sub>Η</sub>17-modulating bile acid metabolites
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin, 2022, Nature on p. 907-912
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Jordan Bisanz, V Upadhyay, J Turnbaugh, K Ly, P Turnbaugh, 2019, Cell Host and Microbe on p. 265-272.e4
Reporting guidelines for human microbiome research: the STORMS checklist
C Mirzayi, A Renson, Cesare Furlanello, F Zohra, Susanna Assunta Sansone, S Elsafoury, Fatima Zohra, L Geistlinger, Shaimaa Elsafoury, L Kasselman, Ludwig Geistlinger, K Eckenrode, J van de Wijgert, Lora J. Kasselman, A Loughman, Kelly Eckenrode, F Marques, Janneke van de Wijgert, D MacIntyre, Amy Loughman, M Arumugam, Francine Z. Marques, David A. MacIntyre, R Azhar, Manimozhiyan Arumugam, F Beghini, K Bergstrom, Rimsha Azhar, A Bhatt, Francesco Beghini, Kirk Bergstrom, J Braun, Ami Bhatt, H Bravo, Jordan E. Bisanz, G Buck, Jonathan Braun, Hector Corrada Bravo, F Bushman, Gregory A. Buck, D Casero, Frederic Bushman, G Clarke, M Collado, David Casero, Gerard Clarke, P Cotter, Maria Carmen Collado, J Cryan, R Demmer, Paul D. Cotter, S Devkota, John F. Cryan, Ryan T. Demmer, E Elinav, Suzanne Devkota, J Escobar, J Fettweis, Eran Elinav, Juan S. Escobar, R Finn, A Fodor, Jennifer Fettweis, Robert D. Finn, S Forslund, A Franke, Anthony A. Fodor, Sofia Forslund, C Furlanello, Andre Franke, J Gilbert, Cesare Furlanello, E Grice, B Haibe-Kains, Jack Gilbert, Elizabeth Grice, S Handley, P Herd, Benjamin Haibe-Kains, S Holmes, Scott Handley, Pamela Herd, J Jacobs, Susan Holmes, L Karstens, R Knight, Jonathan P. Jacobs, Lisa Karstens, D Knights, Rob Knight, O Koren, D Kwon, Dan Knights, M Langille, Omry Koren, B Lindsay, Douglas S. Kwon, D McGovern, A McHardy, S McWeeney, N Mueller, L Nezi, M Olm, N Palm, E Pasolli, J Raes, M Redinbo, M Rühlemann, R Balfour Sartor, P Schloss, L Schriml, E Segal, M Shardell, T Sharpton, E Smirnova, H Sokol, J Sonnenburg, S Srinivasan, L Thingholm, P Turnbaugh, V Upadhyay, R Walls, P Wilmes, T Yamada, G Zeller, M Zhang, N Zhao, L Zhao, W Bao, A Culhane, V Devanarayan, J Dopazo, X Fan, M Fischer, W Jones, R Kusko, C Mason, T Mercer, S Sansone, A Scherer, L Shi, S Thakkar, W Tong, R Wolfinger, C Hunter, N Segata, C Huttenhower, J Dowd, H Jones, L Waldron, 2021, Nature Medicine on p. 1885-1892
Gut microbiota–specific iga<sup>+</sup> B cells traffic to the CNS in active multiple sclerosis
A Pröbstel, X Zhou, R Baumann, S Wischnewski, M Kutza, O Rojas, K Sellrie, A Bischof, K Kim, A Ramesh, R Dandekar, A Greenfield, R Schubert, Jordan Bisanz, S Vistnes, K Khaleghi, J Landefeld, G Kirkish, F Liesche-Starnecker, V Ramaglia, S Singh, E Tran, P Barba, K Zorn, J Oechtering, K Forsberg, L Shiow, R Henry, J Graves, Cree BAC, Bruce A.C. Cree, S Hauser, J Kuhle, J Gelfand, P Andersen, J Schlegel, P Turnbaugh, P Seeberger, J Gommerman, M Wilson, L Schirmer, S Baranzini, 2020, Science immunology
Caloric restriction disrupts the microbiota and colonization resistance
R von Schwartzenberg, Jordan Bisanz, S Lyalina, P Spanogiannopoulos, Q Ang, J Cai, S Dickmann, M Friedrich, S Liu, S Collins, D Ingebrigtsen, S Miller, J Turnbaugh, Andrew D. Patterson, K Pollard, K Mai, J Spranger, P Turnbaugh, 2021, Nature on p. 272-277
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
R Harvie, A Chisholm, Jordan E. Bisanz, J Burton, P Herbison, K Schultz, M Schultz, 2017, World Journal of Gastroenterology on p. 4632-4643
News Articles Featuring Jordan Bisanz
Mar 03, 2025
Synthetic microbiome therapy suppresses bacterial infection without antibiotics
Precise, targeted treatment using limited strains of gut bacteria effectively protected against C. difficile infection, severe symptoms and recurrent infections in mice.
Full Article
Dec 09, 2024
The stories that defined 2024 for the One Health Microbiome Center at Penn State
The One Health Microbiome Center has grown, and 2024’s most popular articles below highlight the determination and innovative research by Center members in the gut microbiome, nutritional sciences, food science and agriculture, in addition to headlines featuring partnerships and internships paving the way for future success.
Full Article
Sep 30, 2024
One Health Microbiome Center launches new video series
The Penn State One Health Microbiome Center (OHMC) announced the launch of a new video series highlighting the center's state-of-the-art resources, research capabilities and collaborative efforts in microbiome sciences.
Full Article
Aug 14, 2024
Early life exposure to common chemical permanently disrupts gut microbiome
Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.
Full Article
Jun 13, 2024
Bisanz named Huck Early Career Chair in Host-Microbiome Interactions
Jordan Bisanz, assistant professor of biochemistry and molecular biology in the Eberly College of Science at Penn State, has been awarded a Dorothy Foehr Huck and J. Lloyd Huck Early Career Chair in Host-Microbiome Interactions.
Full Article
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article
Feb 05, 2024
$1.9M NIH grant to support research on impacts of the microbiome on human health
To help understand how complex communities of microbes impact human health, the National Institutes of Health’s National Institute of General Medical Science has awarded a five-year, $1.9 million Maximizing Investigator’s Research Award to Jordan Bisanz
Full Article
Feb 15, 2023
Free film and panel discussion reveals 'invisible' crisis of the microbial world
At 6 p.m. Thursday, March 2, Penn State’s Microbiome Center will present "The Invisible Extinction" — a movie that spotlights the trailblazing work and charismatic personalities of renowned scientists who aim to save the vanishing microbes that are essential for our survival.
Full Article