Joanna Floros

Evan Pugh Professor of Cellular and Molecular Physiology,OB/GYN

Joanna Floros

Huck Affiliations

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Proteins Surface Active Agents Pulmonary Surfactant Associated Protein A Varespladib Methyl Alveolar Macrophages Genes Knockout Mice Single Nucleotide Polymorphism Infections Lung Klebsiella Pneumoniae Sex Characteristics Proteome Oxidative Stress Macrophages Survival Pulmonary Surfactant Associated Proteins Klebsiella Infections Protein Micrornas Child Surfactant Protein A (Sp A) Macrophage Surfactant Protein A Innate Immunity

Most Recent Publications

Association of surfactant protein A2 with acute respiratory failure in children

Lucy Emery, Elizabeth Kane, Keenan Anderson-Fears, Dajiang Liu, Joanna Floros, Chintan K. Gandhi, 2023, Pediatrics International

The alveolar macrophage toponome of female SP-A knockout mice differs from that of males before and after SP-A1 rescue

David S. Phelps, Vernon M. Chinchilli, Lili Yang, Debra Shearer, Judith Weisz, Xuesheng Zhang, Joanna Floros, 2022, Scientific Reports

Corrigendum: Single nucleotide polymorphisms interactions of the surfactant protein genes associated with respiratory distress syndrome susceptibility in preterm infants (Front. Pediatr, (2021), 9, (682160), 10.3389/fped.2021.682160)

Shaili Amatya, Meixia Ye, Lili Yang, Chintan K. Gandhi, Rongling Wu, Beth Nagourney, Joanna Floros, 2022, Frontiers in Pediatrics

Hydrophilic But Not Hydrophobic Surfactant Protein Genetic Variants Are Associated With Severe Acute Respiratory Syncytial Virus Infection in Children

Lynnlee C. Depicolzuane, Catherine M. Roberts, Neal J. Thomas, Keenan Anderson-Fears, Dajiang Liu, João Paulo Pereira Barbosa, Felipe Rodrigues Souza, André Silva Pimentel, Joanna Floros, Chintan K. Gandhi, 2022, Frontiers in Immunology

The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A<sup>0</sup>)

Nithyananda Thorenoor, Joanna Floros, 2022, Frontiers in Immunology

Single Nucleotide Polymorphisms (SNP) and SNP-SNP Interactions of the Surfactant Protein Genes Are Associated With Idiopathic Pulmonary Fibrosis in a Mexican Study Group; Comparison With Hypersensitivity Pneumonitis

Ata Abbasi, Chixiang Chen, Chintan K. Gandhi, Rongling Wu, Annie Pardo, Moises Selman, Joanna Floros, 2022, Frontiers in Immunology

Comparison of the Toponomes of Alveolar Macrophages From Wild Type and Surfactant Protein A Knockout Mice and Their Response to Infection

David S. Phelps, Vernon M. Chinchilli, Xuesheng Zhang, Debra Shearer, Judith Weisz, Joanna Floros, 2022, Frontiers in Immunology

A Pilot Proteomic Study of Vestibular Fluid From Patients With Vulvodynia

Colin MacNeill, Todd Umstead, Debra Shearer, Judith Weisz, David S. Phelps, Joanna Floros, 2022, Journal of Lower Genital Tract Disease on p. 169-175

SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children

Chintan Gandhi, Neal J. Thomas, Ye Meixia, Debbie Spear, Chenqi Fu, Shouhao Zhou, Rongling Wu, Garrett Keim, Nadir Yehya, Joanna Floros, 2022, Frontiers in Genetics

Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice

Lynnlee Depicolzuane, David S. Phelps, Joanna Floros, 2022, Frontiers in Pediatrics

Most-Cited Papers

Childhood asthma: Causes, risks, and protective factors; a role of innate immunity

Georgios T. Noutsios, Joanna Floros, 2014, Schweizerische Medizinische Wochenschrift

Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure

Guirong Wang, Todd M. Umstead, Sanmei Hu, Anatoly N. Mikerov, David S. Phelps, Joanna Floros, 2019, Frontiers in Immunology

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

Elena Lopez-Rodriguez, Alicia Pascual, Raquel Arroyo, Joanna Floros, Jesus Perez-Gil, 2016, Biophysical Journal on p. 524-536

Genetic association of pulmonary surfactant protein genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis

Zhenwu Lin, Nithyananda Thorenoor, Rongling Wut, Susan L. Di Angelo, Meixia Ye, Neal J. Thomas, Xiaojie Liao, Tony R. Lin, Stuart Warren, Joanna Floros, 2018, Frontiers in Immunology

Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

Nithyananda Thorenoor, Xuesheng Zhang, Todd M. Umstead, E. Scott Halstead, David S. Phelps, Joanna Floros, 2018, Respiratory Research

Survival of surfactant protein-A1 and SP-A2 transgenic mice after Klebsiella pneumoniae infection, exhibits sex-, gene-, and variant specific differences; Treatment with surfactant protein improves survival

Nithyananda Thorenoor, Todd M. Umstead, Xuesheng Zhang, David S. Phelps, Joanna Floros, 2018, Frontiers in Immunology

SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: Pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani, Joanna Floros, 2017, Biology of Sex Differences

Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome

David S. Phelps, Todd M. Umstead, Joanna Floros, 2014, Journal of Proteomics on p. 427-444

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions

Joanna Floros, Nithyananda Thorenoor, Nikolaos Tsotakos, David S. Phelps, 2021, Frontiers in Immunology

SP-R210 (Myo18A) isoforms as intrinsic modulators of macrophage priming and activation

L Yang, M Carrillo, Y Wu, S DiAngelo, P Silveyra, T Umstead, E. Scott Halstead, M Davies, S Hu, Joanna Floros, F McCormack, Neil D. Christensen, Zissis C. Chroneos, 2015, PLoS One on p. e0126576