Jeffrey Peters

Distinguished Professor of Molecular Toxicology and Carcinogenesis

Jeffrey Peters

Research Summary

Roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of homeostasis, toxicology, and carcinogenesis.

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Peroxisome Proliferator Activated Receptors Neoplasms Liver Pharmacological Metabolism Peroxisome Proliferator Activated Receptor Cytoplasmic And Nuclear Receptors Tumors Ppar Alpha Fatty Acid Weight Dose Industrial Substance Sulfonate Perfluorooctane Sulfonic Acid Macrophage Colony Stimulating Factor Perfluorooctane Fatty Acid Synthases Cannabidiolic Acid Fatty Acid Synthase Drug Rodentia Ligands Mass Spectrometry Oxidative Stress Genes

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters, 2024, Biomolecules

2022-2023 Toxicological Sciences: Paper of the Year

Yvonne Will, Jeffrey M. Peters, 2024, Toxicological Sciences on p. 2-3

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice

Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters, 2023, Metabolites

2021-2022 Toxicological Sciences paper of the year

Lei Guo, Jeffrey Peters, 2023, Toxicological Sciences on p. 1--2

Cannabidiolic acid activates the expression of the PPARβ/δ target genes in MDA-MB-231 cells

Masayo Hirao-Suzuki, Koga Takayuki, Masufumi Takiguchi, Jeffrey M. Peters, Shuso Takeda, 2022, Archives of Biochemistry and Biophysics

The role of mouse and human peroxisome proliferator-activated receptor-α in modulating the hepatic effects of perfluorooctane sulfonate in mice

S Su, Laura Billy, Sue Chang, Frank Gonzalez, Andrew D. Patterson, Jeffrey Peters, 2022, Toxicology on p. 153056

Targeting peroxisome proliferator-activated receptor-β/δ (pparβ/δ) for the treatment or prevention of alcoholic liver disease

Takayuki Koga, Jeffrey M. Peters, 2021, Biological and Pharmaceutical Bulletin on p. 1598-1606

Diminished Hepatocarcinogenesis by a Potent, High-Affinity Human PPARα Agonist in PPARA-Humanized Mice

Jennifer E. Foreman, Takayuki Koga, Oksana Kosyk, Boo Hyon Kang, Xiaoyang Zhu, Samuel M. Cohen, Laura J. Billy, Arun K. Sharma, Shantu Amin, Frank J. Gonzalez, Ivan Rusyn, Jeffrey M. Peters, 2021, Toxicological Sciences on p. 70--80

Current Challenges and Recent Developments in Mass Spectrometry-Based Metabolomics

Stephanie Collins, Imhoi Koo, Jeffrey Peters, Philip B. Smith, Andrew D. Patterson, 2021, Annual Review of Analytical Chemistry on p. 467--487

Most-Cited Papers

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed, James E. Klaunig, 2014, Critical Reviews in Toxicology on p. 1-49

Lipid metabolism and lipophagy in cancer

Meenu Maan, Jeffrey Peters, Mainak Dutta, Andrew D. Patterson, 2018, Biochemical and Biophysical Research Communications on p. 582--589

The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions

J. Christopher Corton, Jeffrey M. Peters, James E. Klaunig, 2018, Archiv fur Toxikologie on p. 83-119

M-CSF from cancer cells induces fatty acid synthase and PPARβ/δ activation in tumor myeloid cells, leading to tumor progression

Jonghanne Park, Sang Eun Lee, Jin Hur, Eun Byeol Hong, Jae Il Choi, Ji Min Yang, Ju Young Kim, Young Chan Kim, Hyun Jai Cho, Jeffrey M. Peters, Seung Bum Ryoo, Young Tae Kim, Hyo Soo Kim, 2015, Cell Reports on p. 1614-1625

Establishing the Role of PPARβ/δ in Carcinogenesis

Jeffrey M. Peters, Frank J. Gonzalez, Rolf Müller, 2015, Trends in Endocrinology and Metabolism on p. 595-607

Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity

Pei Li Yao, Jose L. Morales, Bokai Zhu, Boo Hyon Kang, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Molecular Cancer Therapeutics on p. 1008-1017

Interplay Between the Host, the Human Microbiome, and Drug Metabolism

Robert Nichols, Jeffrey Peters, Andrew D. Patterson, 2019, Human Genomics on p. 1--10

Perfluorooctane sulfonate alters gut microbiota-host metabolic homeostasis in mice

Limin Zhang, Bipin Rimal, Robert Nichols, Yuan Tian, Philip B. Smith, Emmanuel Hatzakis, Shu-Ching Chang, John Butenhoff, Jeffrey Peters, Andrew D. Patterson, 2020, Toxicology on p. 152365

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

The Evolution of Carcinogenesis

Jeffrey M. Peters, Frank J. Gonzalez, 2018, Toxicological Sciences on p. 272-276