J. Martin Bollinger

Professor of Chemistry; Professor of Biochemistry and Molecular Biology

J. Martin Bollinger

Research Summary

Mechanisms of metalloenzymes and metallofactor assembly

Huck Affiliations

Links

Most Recent Publications

Structural Elucidation of the Reduced Mn(III)/Fe(III) Intermediate of the Radical-Initiating Metallocofactor in Chlamydia trachomatis Ribonucleotide Reductase

R Martinie, J Livada, N Kothiya, Joseph Bollinger, C Krebs, A Silakov, 2025, Biochemistry on p. 1157-1167

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code

Florence J. Hardy, Matthew G. Quesne, Emilie F. Gérard, Jingming Zhao, Mary Ortmayer, Christopher J. Taylor, Hafiz S. Ali, Jeffrey W. Slater, Colin W. Levy, Derren J. Heyes, J. Martin Bollinger, Sam P. de Visser, Anthony P. Green, 2024, ACS Catalysis on p. 11584-11590

Steric Perturbation of the Grob-like Final Step of Ethylene-Forming Enzyme Enables 3-Hydroxypropionate and Propylene Production

Evan Burke, Rachelle Copeland, Yash Dixit, Carsten Krebs, J. Martin Bollinger, 2024, Journal of the American Chemical Society on p. 1977-1983

Optimized Substrate Positioning Enables Switches in the C−H Cleavage Site and Reaction Outcome in the Hydroxylation−Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase

Eliott Wenger, Ryan Martinie, Richiro Ushimary, Richiro Ushimaru, Christopher Pollock, D Sil, Aaron Li, Nhi Hoang, Gavin Palowitch, Brandt Graham, Irene Schaperdoth, Evan Burke, A Maggiolo, Wei Chang, B Allen, Carsten Krebs, Alexey Silakov, Amie Kathleen Boal, Joseph Bollinger, 2024, Journal of the American Chemical Society on p. 24271-24287

An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, LolO

Juan Pan, E Wnger, Eliott S. Wenger, Chi Yun Lin, B Zhange, Bo Zhang, Debangsu Sil, Irene Schaperdoth, Setareh Saryazdi, Robert B. Grossman, Carsten Krebs, J. Martin Bollinger, 2024, Biochemistry on p. 1674-1683

Capturing a bis-Fe(IV) State in Methylosinus trichosporium OB3b MbnH

Anastasia C. Manesis, Jeffrey W. Slater, Kenny Cantave, Joseph Bollinger, Carsten Krebs, Amy C. Rosenzweig, 2023, Biochemistry on p. 1082-1092

Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

Jeffrey Slater, Chi Lin, M Neugebauer, Monica Neugebauer, M McBride, D Sil, Molly McBride, C Lin, D Sil, Mrutyunjay Nair, B Katch, Amie Boal, Bryce Katch, M Chang, Michelle Chang, A Silakov, C Krebs, Alexey Silakov, J Bollinger Jr., Joseph Bollinger, Carsten Krebs, 2023, Biochemistry on p. 2480-2491

Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily

Molly McBride, Sarah Pope, Mrutyunjay Nair, D Sil, Xavier Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154

An iron–sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities

Nunziata Maio, Md Kausar Raza, Yan Li, De Liang Zhang, J. Martin Bollinger, Carsten Krebs, Tracey A. Rouault, 2023, Proceedings of the National Academy of Sciences of the United States of America

A mixed-valent Fe(II)Fe(III) species converts cysteine to an oxazolone/thioamide pair in methanobactin biosynthesis

Yun Ji Park, Richard J. Jodts, Jeffrey W. Slater, Reyvin M. Reyes, Valerie J. Winton, Rana A. Montaser, Paul M. Thomas, William B. Dowdle, Anahi Ruiz, Neil L. Kelleher, Joseph Bollinger, Carsten Krebs, Brian M. Hoffman, Amy C. Rosenzweig, 2022, Proceedings of the National Academy of Sciences of the United States of America on p. e2123566119

Most-Cited Papers

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449

Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase

Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836

Spectroscopic Evidence for the Two C-H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase

Esta Tamanaha, Bo Zhang, Yisong Guo, Wei Chen Chang, Eric W. Barr, Gang Xing, Jennifer St Clair, Shengfa Ye, Frank Neese, J. Martin Bollinger, Carsten Krebs, 2016, Journal of the American Chemical Society on p. 8862-8874

The biosynthesis of methanobactin

Grace E. Kenney, Laura M.K. Dassama, Maria Eirini Pandelia, Anthony S. Gizzi, Ryan J. Martinie, Peng Gao, Caroline J. DeHart, Luis F. Schachner, Owen S. Skinner, Soo Y. Ro, Xiao Zhu, Monica Sadek, Paul M. Thomas, Steven C. Almo, J. Martin Bollinger, Carsten Krebs, Neil L. Kelleher, Amy C. Rosenzweig, 2018, Science on p. 1411-1416

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

N Maio, Bernard A.P. Lafont, A Lafont, D Sil, Y Li, J. Martin Bollinger, Joseph Bollinger, Carsten Krebs, T Pierson, W. Marston Linehan, M Linehan, Tracey A. Rouault, 2021, Science on p. 236-241

Experimental correlation of substrate position with reaction outcome in the aliphatic halogenase, SyrB2

Ryan J. Martinie, Jovan Livada, Wei Chen Chang, Michael T. Green, Carsten Krebs, J. Martin Bollinger, Alexey Silakov, 2015, Journal of the American Chemical Society on p. 6912-6919

Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

Martin Srnec, Shaun D. Wong, Megan L. Matthews, Carsten Krebs, J. Martin Bollinger, Edward I. Solomon, 2016, Journal of the American Chemical Society on p. 5110-5122

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

J. Martin Bollinger, Wei Chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal, Carsten Krebs, 2015, on p. 95-122

Rapid Reduction of the Diferric-Peroxyhemiacetal Intermediate in Aldehyde-Deformylating Oxygenase by a Cyanobacterial Ferredoxin: Evidence for a Free-Radical Mechanism

Lauren J. Rajakovich, H. Norgaard, Hanne Nørgaard, N. Li, D. Warui, Wei Chen Chang, Ning Li, S. Booker, C. Krebs, Squire J. Booker, J. Bollinger, Jr., Carsten Krebs, J. Martin Bollinger, M. Pandelia, Maria Eirini Pandelia, 2015, Journal of the American Chemical Society on p. 11695-11709