Greg Shearer

Chair, Intercollege Graduate Degree Program in Integrative and Biomedical Physiology; Professor of Nutrition and Physiology

Greg Shearer

Research Summary

We seek to understand disease-related functional changes in the context of global changes in lipid mediators (bioactive metabolites of dietary fatty acids) and use them to identify markers of disease and better ways to prevent or manage disease

Huck Affiliations

Most Recent Publications

A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort

Carmen E. Annevelink, Jason Westra, Aleix Sala-Vila, William S. Harris, Nathan L. Tintle, Gregory C. Shearer, 2024, Journal of Nutrition on p. 1640-1651

Effects of niacin and omega-3 fatty acids on HDL-apolipoprotein A-I exchange in subjects with metabolic syndrome

Mark S. Borja, Bradley Hammerson, Chongren Tang, Litzy Juarez-Serrano, Olga V. Savinova, William S. Harris, Michael N. Oda, Gregory C. Shearer, 2024, PLoS One

Metabolomics and Risk of Dementia: A Systematic Review of Prospective Studies

Ashley C. Flores, Xinyuan Zhang, Penny M. Kris-Etherton, Martin J. Sliwinski, Greg C. Shearer, Xiang Gao, Muzi Na, 2024, Journal of Nutrition on p. 826-845

Oxylipin transport by lipoprotein particles and its functional implications for cardiometabolic and neurological disorders

Nuanyi Liang, Brian A. Harsch, Sitong Zhou, Alison Borkowska, Gregory C. Shearer, Rima Kaddurah-Daouk, John W. Newman, Kamil Borkowski, 2024, Progress in Lipid Research

Diet-derived and diet-related endogenously produced palmitic acid: Effects on metabolic regulation and cardiovascular disease risk

Carmen E. Annevelink, Philip A. Sapp, Kristina Petersen, Greg C. Shearer, Penny M. Kris-Etherton, 2023, Journal of Clinical Lipidology on p. 577-586

Genome-wide association study of Red Blood Cell fatty acids in the Women's Health Initiative Memory Study

Jason Westra, Carmen Annevelink, Tonya Orchard, Lifang Hou, William S. Harris, Timothy D. O'Connell, Gregory Shearer, Nathan Tintle, 2023, Prostaglandins Leukotrienes and Essential Fatty Acids

FFAR4 regulates cardiac oxylipin balance to promote inflammation resolution in HFpEF secondary to metabolic syndrome

Naixin Zhang, Brian Harsch, Michael J. Zhang, Dylan J. Gyberg, Jackie A. Stevens, Brandon M. Wagner, Jenna Mendelson, Michael T. Patterson, Devin A. Orchard, Chastity L. Healy, Jesse W. Williams, De Wayne Townsend, Gregory C. Shearer, Katherine A. Murphy, Timothy D. O'Connell, 2023, Journal of Lipid Research

Effect of omega-3 ethyl esters on the triglyceride-rich lipoprotein response to endotoxin challenge in healthy young men

Rachel E. Walker, Chesney K. Richter, Ann C. Skulas-Ray, Michael R. Flock, Brian A. Harsch, Carmen E. Annevelink, Penny M. Kris-Etherton, Gordon L. Jensen, Gregory C. Shearer, 2023, Journal of Lipid Research

Esterified Oxylipins: Do They Matter?

Carmen E. Annevelink, Rachel E. Walker, Gregory C. Shearer, 2022, Metabolites

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer, 2022, Physiology on p. 311-322

Most-Cited Papers

Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

Vishal Singh, Beng San Yeoh, Rachel Walker, Xia Xiao, Piu Saha, Rachel Golonka, Jingwei Cai, Alexis Bretin, Bretin ACA, Xi Cheng, Qing Liu, Michael Flythe, Benoit Chassaing, Gregory C. Shearer, Andrew D. Patterson, Andrew Gewirtz, Matam Vijay-Kumar, 2019, Gut on p. 1801-1812

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

Vishal Singh, Benoit Chassaing, Limin Zhang, Beng San Yeoh, Xia Xiao, Manish Kumar, Mark T. Baker, Jingwei Cai, Rachel Walker, Kamil Borkowski, Kevin J. Harvatine, Nagendra Singh, Gregory C. Shearer, James M. Ntambi, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2015, Cell Metabolism on p. 983-996

Longitudinal study of alcohol consumption and HDL concentrations: A community-based study

Shue Huang, Junjuan Li, Gregory C. Shearer, Alice H. Lichtenstein, Xiaoming Zheng, Yuntao Wu, Cheng Jin, Shouling Wu, Xiang Gao, 2017, American Journal of Clinical Nutrition on p. 905-912

Oleic acid-derived oleoylethanolamide: A nutritional science perspective

Kate J. Bowen, Penny M. Kris-Etherton, Gregory C. Shearer, Sheila G. West, Lavanya Reddivari, Peter J.H. Jones, 2017, Progress in Lipid Research on p. 1-15

An overview of the biologic effects of omega-6 oxylipins in humans

Gregory C. Shearer, Rachel E. Walker, 2018, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 26-38

Predicting the effects of supplemental EPA and DHA on the omega-3 index

R Walker, Kristina Harris Jackson, Kristina Harris-Jackson, N Tintle, Gregory Shearer, A Bernasconi, S Masson, R Latini, B Heydari, R Kwong, M Flock, Penny M. Kris-Etherton, A Hedengran, R Carney, A Skulas-Ray, S Gidding, A Dewell, C Gardner, S Grenon, B Sarter, J Newman, T Pedersen, M Larson, W Harris, 2019, American Journal of Clinical Nutrition on p. 1034-1040

A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study

N. L. Tintle, J. V. Pottala, S. Lacey, V. Ramachandran, J. Westra, A. Rogers, J. Clark, B. Olthoff, M. Larson, W. Harris, G. C. Shearer, 2015, Prostaglandins Leukotrienes and Essential Fatty Acids on p. 65-72

ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4

Timothy D. O'Connell, Robert C. Block, Shue P. Huang, Gregory C. Shearer, 2017, Journal of Molecular and Cellular Cardiology on p. 74-92

Omega-6 fatty acids and cardiovascular disease friend, not foe?

William S. Harris, Gregory C. Shearer, 2014, Circulation on p. 1562-1564

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: Potential role of free fatty acid receptor 4

Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell, 2015, Journal of Lipid Research on p. 2297-2308