Gary Perdew

H. Thomas and Dorothy Willits Hallowell Chair in Agricultural Sciences


Gary Perdew

Research Summary

Mechanisms of receptor-mediated carcinogenesis.

Huck Affiliations

Links

News Articles Featuring Gary Perdew

Jan 30, 2026

Liver metabolism of an essential amino acid may play a key role in gut health

Many biological processes exhibit daytime differences governed by rhythmic exposure to sunlight, termed circadian rhythms. Researchers at Penn State recently found, in mice, that a protein critical to intestinal barrier function — helping the gut absorb nutrients while blocking harmful pathogens — is rhythmically controlled by nighttime liver metabolism of the molecule tryptophan.

Full Article

Aug 14, 2024

Early life exposure to common chemical permanently disrupts gut microbiome

Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.

Full Article

Apr 06, 2023

Broccoli consumption protects gut lining, reduces disease, in mice

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

Full Article

Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Full Article

Mar 30, 2020

Examining Links Between AHR, Microbiome, and Immune Functions

Gary Perdew, Ph.D., studies how the aryl hydrocarbon receptor (AHR) pathway interacts with the microbiome, the immune system, and protective barriers in skin and the gut.

Full Article