Emily Weinert
Professor of Biochemistry and Molecular Biology
-
306 Althouse Lab
University Park, PA - eew5225@psu.edu
- 814-865-3719
Research Summary
The mechanisms by which bacteria sense and respond to the environment, as well as how these signaling proteins/pathways affect competition, host colonization, and pathogenesis.
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- One Health Microbiome Center
- Center for Structural Biology
- Center for RNA Molecular Biology
Links
Most Recent Publications
Heme pocket hydrogen bonding residue interactions within the Pectobacterium Diguanylate cyclase-containing globin coupled sensor: A resonance Raman study
Nushrat J. Hoque, Shannon Rivera, Paul G. Young, Emily E. Weinert, Yilin Liu, 2024, Journal of Inorganic Biochemistry
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
Heme pocket modulates protein conformation and diguanylate cyclase activity of a tetrameric globin coupled sensor
Emily Weinert, Jacob R. Potter, Shannon Rivera, Paul G. Young, Dayna C. Patterson, Kevin E. Namitz, Neela Yennawar, James R. Kincaid, Yilin Liu, 2024, Journal of Inorganic Biochemistry on p. 112638
Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm
Emily Weinert, Ariel Schuelke-Sanchez, Neela H. Yennawar, 2024, Journal of Inorganic Biochemistry on p. 112482
Bacterial Oxygen Sensing by Globin Coupled Sensor Proteins
Emily Weinert, 2024, Encyclopedia of Inorganic and Bioinorganic Chemistry
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins
Nushrat J. Hoque, Emily E. Weinert, 2023, Current Opinion in Microbiology
Strain-Specific Gifsy-1 Prophage Genes Are Determinants for Expression of the RNA Repair Operon during the SOS Response in Salmonella enterica Serovar Typhimurium
Jennifer E. Kurasz, Madison C. Crawford, Steffen Porwollik, Oliver Gregory, Katerina R. Tadlock, Eve C. Balding, Emily E. Weinert, Michael McClelland, Anna C. Karls, 2023, Journal of Bacteriology
An O<sub>2</sub>-sensing diguanylate cyclase broadly affects the aerobic transcriptome in the phytopathogen Pectobacterium carotovorum
Florian J. Fekete, Nick J. Marotta, Xuanyu Liu, Emily E. Weinert, 2023, Frontiers in Microbiology
Spectrophotometric Method for the Quantification and Kinetic Evaluation of In Vitro c-di-GMP Hydrolysis in the Presence and Absence of Oxygen
Dayna C. Patterson, Emily E. Weinert, 2023, on p. 87-98
In Vitro Measurement of Gas-Dependent and Redox-Sensitive Diguanylate Cyclase Activity
Nushrat J. Hoque, Madison P. Helm, Emily E. Weinert, 2023, on p. 75-86
Most-Cited Papers
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
J Bisanz, Bipin Rimal, Stephanie Collins, Emily Weinert, Ceylan Tanes, A Patterson, Megan Granda, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Erin Reilly, Kristopher Krausz, Dhimant Desai, Fuhua Hao, Shantu Amin, Devendra Paudel, Edson Rocha, Vishal Singh, James Coleman, Tingting Yan, Yatrik Shah, Min Kim, Kyle Bittinger, Frank Gonzalez, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John Heuvel, John P. Vanden Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Andrew Patterson, 2024, Nature on p. 859-868
Identification of ellagic acid rhamnoside as a bioactive component of a complex botanical extract with anti-biofilm activity
Benjamin M. Fontaine, Kate Nelson, James T. Lyles, Parth B. Jariwala, Jennifer M. García-Rodriguez, Cassandra L. Quave, Emily E. Weinert, 2017, Frontiers in Microbiology
Mechanism and Role of Globin-Coupled Sensor Signalling
Johnnie A. Walker, Shannon Rivera, Emily E. Weinert, 2017, on p. 133-169
An O<sub>2</sub>-sensing stressosome from a Gram-negative bacterium
Xin Jia, Jian Bo Wang, Shannon Rivera, Duc Duong, Emily E. Weinert, 2016, Nature Communications
RNase I regulates Escherichia coli 2<sup>0</sup>,3<sup>0</sup>-cyclic nucleotide monophosphate levels and biofilm formation
Benjamin M. Fontaine, Kevin S. Martin, Jennifer M. Garcia-Rodriguez, Claire Jung, Laura Briggs, Jessica E. Southwell, Xin Jia, Emily E. Weinert, 2018, Biochemical Journal on p. 1491-1506
Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors
Shannon Rivera, Paul G. Young, Eric D. Hoffer, Gregory E. Vansuch, Carmen L. Metzler, Christine M. Dunham, Emily E. Weinert, 2018, Inorganic Chemistry on p. 14386-14395
Oxygen and Bis(3',5')-cyclic Dimeric Guanosine Monophosphate Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors
Justin L. Burns, Shannon Rivera, D. Douglas Deer, Shawnna C. Joynt, David Dvorak, Emily E. Weinert, 2016, Biochemistry on p. 6642-6651
Oxygen-Dependent Globin Coupled Sensor Signaling Modulates Motility and Virulence of the Plant Pathogen Pectobacterium carotovorum
Justin L. Burns, Parth B. Jariwala, Shannon Rivera, Benjamin M. Fontaine, Laura Briggs, Emily E. Weinert, 2017, ACS Chemical Biology on p. 2070-2077
Exploring the Links between Nucleotide Signaling and Quorum Sensing Pathways in Regulating Bacterial Virulence
Benjamin M. Fontaine, Yashasvika Duggal, Emily E. Weinert, 2018, ACS Infectious Diseases on p. 1645-1655
Globin domain interactions control heme pocket conformation and oligomerization of globin coupled sensors
Shannon Rivera, Justin L. Burns, Gregory E. Vansuch, Bryant Chica, Emily E. Weinert, 2016, Journal of Inorganic Biochemistry on p. 70-76
News Articles Featuring Emily Weinert
Feb 28, 2024
New role for bacterial enzyme in gut metabolism revealed
Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.
Full Article