Elizabeth Proctor

Associate Professor of Neurosurgery and of Pharmacology

Elizabeth Proctor

Research Summary

Systems biology of complex disease. Integration of heterogeneous data types across length scales.

Huck Affiliations

Links

Most Recent Publications

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer’s disease-associated metabolites

Brendan K. Ball, Madison K. Kuhn, Rebecca M. Fleeman Bechtel, Elizabeth A. Proctor, Douglas K. Brubaker, 2024, Scientific Reports

Microglial drivers of Alzheimer’s disease pathology: diverse but converging dysfunctional states

Madison Kuhn, Elizabeth Proctor, 2024, Proteins: Structure, Function, and Bioinformatics

Everolimus alleviates CD4<sup>+</sup> T cell inflammation by regulating autophagy and cellular redox homeostasis

Jack Donato Rockhold, Heather Marszalkowski, Marco Sannella, Kaleigh Gibney, Lyanne Murphy, Emelia Zukowski, Gabriella H. Kalantar, Sara SantaCruz-Calvo, Samantha N. Hart, Madison K. Kuhn, Jingting Yu, Olivia Stefanik, Gabrielle Chase, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath, 2024, GeroScience

Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism

Madison K. Kuhn, Rebecca M. Fleeman, Lynne M. Beidler, Amanda Snyder, Dennis C. Chan, Elizabeth A. Proctor, 2023, Cellular and Molecular Bioengineering on p. 405-421

Apolipoprotein E ε4 modulates astrocyte neuronal support functions in the presence of amyloid-β

Rebecca M. Fleeman, Madison K. Kuhn, Dennis C. Chan, Elizabeth A. Proctor, 2023, Journal of Neurochemistry on p. 536-549

STAT3 modulates CD4<sup>+</sup> T mitochondrial dynamics and function in aging

Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella H. Kalantar, Jingting Yu, Sara SantaCruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath, 2023, Aging Cell

Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice

Rebecca Fleeman, A Snyder, M Kuhn, D Chan, G Smith, Nicole Crowley, Amy Arnold, Elizabeth Proctor, 2022, Neurobiology of Aging on p. 154-169

Monosialotetrahexosylganglioside Promotes Early Aβ42 Oligomer Formation and Maintenance

D Zhang, J Wang, R Fleeman, M Kuhn, Matthew Swulius, Elizabeth Proctor, Nikolay V. Dokholyan, 2022, ACS Chemical Neuroscience on p. 1979-1991

Astrocytic Propagation of Tau in the Context of Alzheimer's Disease

Rebecca M. Fleeman, Elizabeth A. Proctor, 2021, Frontiers in Cellular Neuroscience

Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Andrew Simonson^, Andrew W. Simonson, A Mongia, Agustey Mongia^, Matthew R. Aronson, Agustey S. Mongia, M Aronson, Matthew Aronson^, John N. Alumasa, Dennis Chan, Adam Bolotsky, Atip Lawanprasert^, A Lawanprasert, Michael Howe, Aida Ebrahimi, Elizabeth Proctor, Adam Bolotsky, T. Mal, Kenneth C. Keiler, Scott H. Medina, Christy George, S Ebrahimi, A Ebrahimi, A Baughn, Elizabeth Proctor, Kenneth Keiler, Scott Medina*, S Medina, 2020, Nature Biomedical Engineering on p. 467-480

Most-Cited Papers

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath, Madhur Agrawal, Grace McCambridge, Dequina A. Nicholas, Hatice Hasturk, Jing Liu, Kai Jiang, Rui Liu, Zhenheng Guo, Jude Deeney, Caroline M. Apovian, Jennifer Snyder-Cappione, Gregory S. Hawk, Rebecca M. Fleeman, Riley M.F. Pihl, Katherine Thompson, Anna C. Belkina, Licong Cui, Elizabeth A. Proctor, Philip A. Kern, Barbara S. Nikolajczyk, 2020, Cell Metabolism on p. 44-55.e6

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Dequina A. Nicholas, Elizabeth A. Proctor, Madhur Agrawal, Anna C. Belkina, Stephen C. Van Nostrand, Leena Panneerseelan-Bharath, Albert R. Jones, Forum Raval, Blanche C. Ip, Min Zhu, Jose M. Cacicedo, Chloe Habib, Nestor Sainz-Rueda, Leah Persky, Patrick G. Sullivan, Barbara E. Corkey, Caroline M. Apovian, Philip A. Kern, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2019, Cell Metabolism on p. 447-461.e5

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis

Elizabeth A. Proctor, Lanette Fee, Yazhong Tao, Rachel L. Redler, James M. Fay, Yuliang Zhang, Zhengjian Lv, Ian P. Mercer, Mohanish Deshmukh, Yuri L. Lyubchenko, Nikolay V. Dokholyan, 2016, Proceedings of the National Academy of Sciences of the United States of America on p. 614-619

Neurovascular coupling and bilateral connectivity during nrem and rem sleep

Kevin L. Turner, Kyle W. Gheres, Elizabeth A. Proctor, Patrick J. Drew, 2020, eLife on p. 1

Applications of Discrete Molecular Dynamics in biology and medicine

Elizabeth A. Proctor, Nikolay V. Dokholyan, 2016, Current Opinion in Structural Biology on p. 9-13

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening

Levi B. Wood, Ashley R. Winslow, Elizabeth A. Proctor, Declan McGuone, Daniel A. Mordes, Matthew P. Frosch, Bradley T. Hyman, Douglas A. Lauffenburger, Kevin M. Haigis, 2015, Scientific Reports

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis

Dequina Nicholas, Elizabeth A. Proctor, Forum M. Raval, Blanche C. Ip, Chloe Habib, Eleni Ritou, Tom N. Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M. Apovian, Douglas A. Lauffenburger, Barbara S. Nikolajczyk, 2017, PLoS One

Cu,Zn-superoxide dismutase without Zn is folded but catalytically inactive

Sean Nedd, Rachel L. Redler, Elizabeth A. Proctor, Nikolay V. Dokholyan, Anastassia N. Alexandrova, 2014, Journal of Molecular Biology on p. 4112-4124

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Elizabeth A. Proctor, Pradeep Kota, Andrei A. Aleksandrov, Lihua He, John R. Riordan, Nikolay V. Dokholyan, 2015, Chemical Science on p. 1237-1246

Computational approaches to understanding protein aggregation in neurodegeneration

Rachel L. Redler, David Shirvanyants, Onur Dagliyan, Feng Ding, Doo Nam Kim, Pradeep Kota, Elizabeth A. Proctor, Srinivas Ramachandran, Arpit Tandon, Nikolay V. Dokholyan, 2014, Journal of Molecular Cell Biology on p. 104-115