David Boehr

Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. De Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris De Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J.M. van Kuppeveld, 2015, PLoS Pathogens on p. 1-23

Biophysical and computational methods to analyze amino acid interaction networks in proteins

Kathleen F. O'Rourke, Scott D. Gorman, David D. Boehr, 2016, Computational and Structural Biotechnology Journal on p. 245-251

Amino acid networks in a (β/α)<sub>8</sub> barrel enzyme change during catalytic turnover

Jennifer M. Axe, Eric M. Yezdimer, Kathleen F. Orourke, Nicole E. Kerstetter, Wanli You, Chia En A. Chang, David D. Boehr, 2014, Journal of the American Chemical Society on p. 6818-6821

Engineered control of enzyme structural dynamics and function

David D. Boehr, Rebecca N. D'Amico, Kathleen F. O'Rourke, 2018, Protein Science on p. 825-838

Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase

Ibrahim M. Moustafa, Victoria K. Korboukh, Jamie J. Arnold, Eric D. Smidansky, Laura L. Marcotte, David W. Gohara, Xiaorong Yang, María Antonieta Saánchez-Farraán, David Filman, Janna K. Maranas, David D. Boehr, James M. Hogle, Coray M. Colina, Craig E. Cameron, 2014, Journal of Biological Chemistry on p. 36229-36248

The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain

Djoshkun Shengjuler, Yan Mei Chan, Simou Sun, Ibrahim M. Moustafa, Zhen Lu Li, David W. Gohara, Matthias Buck, Paul S. Cremer, David D. Boehr, Craig E. Cameron, 2017, Structure with Folding & design on p. 1875-1886.e7

Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase

Jennifer M. Axe, Kathleen F. O'Rourke, Nicole E. Kerstetter, Eric M. Yezdimer, Yan M. Chan, Alexander Chasin, David D. Boehr, 2015, Protein Science on p. 484-494

David Boehr

Associate Professor of Chemistry

Research Summary

Huck Affiliations

Most Recent Publications

Editorial: Allosteric functions and inhibitions: structural insights

Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNA

Allostery, engineering and inhibition of tryptophan synthase

Direct interactions between picornavirus 3CD protein and phosphoinositide lipids in virus replication organelles

Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces

Special Issue “10th Anniversary of Catalysts: Biocatalysis in Analysis and Synthesis—Past, Present and Future”

Catalyst-Based Biomolecular Logic Gates

Allosteric networks regulate function in multi-enzyme complexes

Differences in Conformational Dynamics Between a Viral Polyprotein and Its Processed Products in Functionally Relevant Regions Revealed by Solution-State NMR Spectroscopy

Conformational Transitions in Yeast Chorismate Mutase Important for Allosteric Regulation as Identified by Nuclear Magnetic Resonance Spectroscopy

Most-Cited Papers

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Biophysical and computational methods to analyze amino acid interaction networks in proteins

Amino acid networks in a (β/α)<sub>8</sub> barrel enzyme change during catalytic turnover

Engineered control of enzyme structural dynamics and function

Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase

The RNA-Binding Site of Poliovirus 3C Protein Doubles as a Phosphoinositide-Binding Domain

Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase

Assigning methyl resonances for protein solution-state NMR studies

Rational Control of Poliovirus RNA-Dependent RNA Polymerase Fidelity by Modulating Motif-D Loop Conformational Dynamics

Triphosphate reorientation of the incoming nucleotide as a fidelity checkpoint in viral RNA-dependent RNA Polymerases