Daniela Zarnescu
Professor of Cellular and Molecular Physiology
Research Summary
Uncovering the molecular mechanisms of aging and neurodegenerative diseases with a focus on RNA processing and cellular metabolism.
Links
Most Recent Publications
Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
R. Keating Godfrey, Eric Alsop, Reed T. Bjork, Brijesh S. Chauhan, Hillary C. Ruvalcaba, Jerry Antone, Lauren M. Gittings, Allison F. Michael, Christi Williams, Grace Hala’ufia, Alexander D. Blythe, Megan Hall, Rita Sattler, Kendall Van Keuren-Jensen, Daniela C. Zarnescu, 2023, Acta neuropathologica communications
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Shu Ting Hung, Gabriel R. Linares, Wen Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Couto, Jesse Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zlokovic, Dion K. Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen Biao Gao, Justin K. Ichida, 2023, Cell on p. 786-802.e28
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
Reed T. Bjork, Nicholas P. Mortimore, Suvithanandhini Loganathan, Daniela C. Zarnescu, 2022, Frontiers in Neuroscience
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Suvithanandhini Loganathan, Bryce A. Wilson, Sara B. Carey, Ernesto Manzo, Archi Joardar, Berrak Ugur, Daniela C. Zarnescu, 2022, Metabolites
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Erik M. Lehmkuhl, Suvithanandhini Loganathan, Eric Alsop, Alexander D. Blythe, Tina Kovalik, Nicholas P. Mortimore, Dianne Barrameda, Chuol Kueth, Randall J. Eck, Bhavani B. Siddegowda, Archi Joardar, Hannah Ball, Maria E. Macias, Robert Bowser, Kendall Van Keuren-Jensen, Daniela C. Zarnescu, 2021, Acta neuropathologica communications
Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy
Suvithanandhini Loganathan, Hannah E. Ball, Ernesto Manzo, Daniela C. Zarnescu, 2021, Journal of Visualized Experiments
Author Correction: Mutations disrupting neuritogenesis genes confer risk for cerebral palsy (Nature Genetics, (2020), 52, 10, (1046-1056), 10.1038/s41588-020-0695-1)
Sheng Chih Jin, Sara A. Lewis, Somayeh Bakhtiari, Xue Zeng, Michael C. Sierant, Sheetal Shetty, Sandra M. Nordlie, Aureliane Elie, Mark A. Corbett, Bethany Y. Norton, Clare L. van Eyk, Shozeb Haider, Brandon S. Guida, Helen Magee, James Liu, Stephen Pastore, John B. Vincent, Janice Brunstrom-Hernandez, Antigone Papavasileiou, Michael C. Fahey, Jesia G. Berry, Kelly Harper, Chongchen Zhou, Junhui Zhang, Boyang Li, Hongyu Zhao, Jennifer Heim, Dani L. Webber, Mahalia S.B. Frank, Lei Xia, Yiran Xu, Dengna Zhu, Bohao Zhang, Amar H. Sheth, James R. Knight, Christopher Castaldi, Irina R. Tikhonova, Francesc López-Giráldez, Boris Keren, Sandra Whalen, Julien Buratti, Diane Doummar, Megan Cho, Kyle Retterer, Francisca Millan, Yangong Wang, Jeff L. Waugh, Lance Rodan, Julie S. Cohen, Ali Fatemi, Angela E. Lin, John P. Phillips, Timothy Feyma, Suzanna C. MacLennan, Spencer Vaughan, Kylie E. Crompton, Susan M. Reid, Dinah S. Reddihough, Qing Shang, Chao Gao, Iona Novak, Nadia Badawi, Yana A. Wilson, Sarah J. McIntyre, Shrikant M. Mane, Xiaoyang Wang, David J. Amor, Daniela C. Zarnescu, Qiongshi Lu, Qinghe Xing, Changlian Zhu, Kaya Bilguvar, Sergio Padilla-Lopez, Richard P. Lifton, Jozef Gecz, Alastair H. MacLennan, Michael C. Kruer, 2021, Nature Genetics on p. 412
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser, 2021, Neurobiology of Disease
Think globally, act locally: Centrosome-localized mRNAs ensure mitotic fidelity
Daniela C. Zarnescu, 2020, Journal of Cell Biology
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
Sheng Chih Jin, Sara A. Lewis, Somayeh Bakhtiari, Xue Zeng, Michael C. Sierant, Sheetal Shetty, Sandra M. Nordlie, Aureliane Elie, Mark A. Corbett, Bethany Y. Norton, Clare L. van Eyk, Shozeb Haider, Brandon S. Guida, Helen Magee, James Liu, Stephen Pastore, John B. Vincent, Janice Brunstrom-Hernandez, Antigone Papavasileiou, Michael C. Fahey, Jesia G. Berry, Kelly Harper, Chongchen Zhou, Junhui Zhang, Boyang Li, Jennifer Heim, Dani L. Webber, Mahalia S.B. Frank, Lei Xia, Yiran Xu, Dengna Zhu, Bohao Zhang, Amar H. Sheth, James R. Knight, Christopher Castaldi, Irina R. Tikhonova, Francesc López-Giráldez, Boris Keren, Sandra Whalen, Julien Buratti, Diane Doummar, Megan Cho, Kyle Retterer, Francisca Millan, Yangong Wang, Jeff L. Waugh, Lance Rodan, Julie S. Cohen, Ali Fatemi, Angela E. Lin, John P. Phillips, Timothy Feyma, Suzanna C. MacLennan, Spencer Vaughan, Kylie E. Crompton, Susan M. Reid, Dinah S. Reddihough, Qing Shang, Chao Gao, Iona Novak, Nadia Badawi, Yana A. Wilson, Sarah J. McIntyre, Shrikant M. Mane, Xiaoyang Wang, David J. Amor, Daniela C. Zarnescu, Qiongshi Lu, Qinghe Xing, Changlian Zhu, Kaya Bilguvar, Sergio Padilla-Lopez, Richard P. Lifton, Jozef Gecz, Alastair H. MacLennan, Michael C. Kruer, 2020, Nature Genetics on p. 1046-1056
Most-Cited Papers
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
Ching Chieh Chou, Yi Zhang, Mfon E. Umoh, Spencer W. Vaughan, Ileana Lorenzini, Feilin Liu, Melissa Sayegh, Paul G. Donlin-Asp, Yu Han Chen, Duc M. Duong, Nicholas T. Seyfried, Maureen A. Powers, Thomas Kukar, Chadwick M. Hales, Marla Gearing, Nigel J. Cairns, Kevin B. Boylan, Dennis W. Dickson, Rosa Rademakers, Yong Jie Zhang, Leonard Petrucelli, Rita Sattler, Daniela C. Zarnescu, Jonathan D. Glass, Wilfried Rossoll, 2018, Nature Neuroscience on p. 228-239
FUTSCH/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis
Alyssa N. Coyne, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G. Daniel, Antony Pearson, Robert Bowser, Daniela C. Zarnescu, 2014, Journal of Neuroscience on p. 15962-15974
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
Sheng Chih Jin, Sara A. Lewis, Somayeh Bakhtiari, Xue Zeng, Michael C. Sierant, Sheetal Shetty, Sandra M. Nordlie, Aureliane Elie, Mark A. Corbett, Bethany Y. Norton, Clare L. van Eyk, Shozeb Haider, Brandon S. Guida, Helen Magee, James Liu, Stephen Pastore, John B. Vincent, Janice Brunstrom-Hernandez, Antigone Papavasileiou, Michael C. Fahey, Jesia G. Berry, Kelly Harper, Chongchen Zhou, Junhui Zhang, Boyang Li, Jennifer Heim, Dani L. Webber, Mahalia S.B. Frank, Lei Xia, Yiran Xu, Dengna Zhu, Bohao Zhang, Amar H. Sheth, James R. Knight, Christopher Castaldi, Irina R. Tikhonova, Francesc López-Giráldez, Boris Keren, Sandra Whalen, Julien Buratti, Diane Doummar, Megan Cho, Kyle Retterer, Francisca Millan, Yangong Wang, Jeff L. Waugh, Lance Rodan, Julie S. Cohen, Ali Fatemi, Angela E. Lin, John P. Phillips, Timothy Feyma, Suzanna C. MacLennan, Spencer Vaughan, Kylie E. Crompton, Susan M. Reid, Dinah S. Reddihough, Qing Shang, Chao Gao, Iona Novak, Nadia Badawi, Yana A. Wilson, Sarah J. McIntyre, Shrikant M. Mane, Xiaoyang Wang, David J. Amor, Daniela C. Zarnescu, Qiongshi Lu, Qinghe Xing, Changlian Zhu, Kaya Bilguvar, Sergio Padilla-Lopez, Richard P. Lifton, Jozef Gecz, Alastair H. MacLennan, Michael C. Kruer, 2020, Nature Genetics on p. 1046-1056
Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS
Alyssa N. Coyne, Ileana Lorenzini, Ching Chieh Chou, Meaghan Torvund, Robert S. Rogers, Alexander Starr, Benjamin L. Zaepfel, Jennifer Levy, Jeffrey Johannesmeyer, Jacob C. Schwartz, Hiroshi Nishimune, Konrad Zinsmaier, Wilfried Rossoll, Rita Sattler, Daniela C. Zarnescu, 2017, Cell Reports on p. 110-125
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS
Ernesto Manzo, Ileana Lorenzini, Dianne Barrameda, Abigail G. O’Conner, Jordan M. Barrows, Alexander Starr, Tina Kovalik, Benjamin E. Rabichow, Erik M. Lehmkuhl, Dakotah D. Shreiner, Archi Joardar, Jean Charles Liévens, Robert Bowser, Rita Sattler, Daniela C. Zarnescu, 2019, eLife
Endocytosis regulates TDP-43 toxicity and turnover
Guangbo Liu, Alyssa N. Coyne, Fen Pei, Spencer Vaughan, Matthew Chaung, Daniela C. Zarnescu, J. Ross Buchan, 2017, Nature Communications
Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation
Alyssa N. Coyne, Shizuka B. Yamada, Bhavani Bagevalu Siddegowda, Patricia S. Estes, Benjamin L. Zaepfel, Jeffrey S. Johannesmeyer, Donovan B. Lockwood, Linh T. Pham, Michael P. Hart, Joel A. Cassel, Brian Freibaum, Ashley V. Boehringer, J. Paul Taylor, Allen B. Reitz, Aaron D. Gitler, Daniela C. Zarnescu, 2015, Human Molecular Genetics on p. 6886-6898
PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43
Archi Joardar, Judith Menzl, Taylor C. Podolsky, Ernesto Manzo, Patricia S. Estes, Sarah Ashford, Daniela C. Zarnescu, 2015, Human Molecular Genetics on p. 1741-1754
Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)
Liberty François-Moutal, Razaz Felemban, David D. Scott, Melissa R. Sayegh, Victor G. Miranda, Samantha Perez-Miller, Rajesh Khanna, Vijay Gokhale, Daniela C. Zarnescu, May Khanna, 2019, ACS Chemical Biology on p. 2006-2013
Medium-chain fatty acids, beta-hydroxybutyric acid and genetic modulation of the carnitine shuttle are protective in a drosophila model of ALS based on TDP-43
Ernesto Manzo, Abigail G. O’Conner, Jordan M. Barrows, Dakotah D. Shreiner, Gabriel J. Birchak, Daniela C. Zarnescu, 2018, Frontiers in Molecular Neuroscience