Christian Huber

Assistant Professor of Biology

Christian Huber

Research Summary

How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

The complete sequence and comparative analysis of ape sex chromosomes

Kateryna D. Makova, Brandon Pickett, R Harris, Gabrielle Hartley, Monika Cechova, Karol Pal, Sergey Nurk, DongAhn Yoo, Qiuhui Li, Prajna Hebbar, B McGrath, Francesca Antonacci, Margaux Aubel, Arjun Biddanda, Matthew Borchers, Erich Bornberg-Bauer, Gerard Bouffard, Shelise Brooks, Lucia Carbone, Laura Carrel, Andrew Carroll, Pi-Chuan Chang, Chen-Shan Chin, Daniel Cook, S Craig, Luciana de Gennaro, Mark Diekhans, Amalia Dutra, Gage Garcia, Patrick Grady, Richard Green, Diana Haddad, Pille Hallast, William Harvey, Glenn Hickey, David Hillis, Savannah Hoyt, Hyeonsoo Jeong, Kaivan Kamali, Sergei Pond, Troy LaPolice, Charles Lee, Alexandra Lewis, Yong-Hwee Loh, Patrick Masterson, Kelly McGarvey, Rajiv McCoy, P Medvedev, Karen Miga, Katherine Munson, Evgenia Pak, Benedict Paten, Brendan Pinto, Tamara Potapova, Arang Rhie, Joana Rocha, Fedor Ryabov, Oliver Ryder, Samuel Sacco, Kishwar Shafin, Valery Shepelev, Viviane Slon, Steven Solar, Jessica Storer, Peter Sudmant, Sweetalana, Sweetalana, Alex Sweeten, Michael Tassia, Françoise Thibaud-Nissen, Thibaud-Nissen, Fran\ccoise, Mario Ventura, Melissa Wilson, Alice Young, Huiqing Zeng, Xinru Zhang, Z Szpiech, Christian D. Huber, Jennifer Gerton, Soojin Yi, Michael Schatz, Ivan Alexandrov, Sergey Koren, Rachel O'Neill, Rachel J. O’Neill, Evan Eichler, Adam Phillippy, 2024, Nature on p. 401-411

Population genetic simulation: Benchmarking frameworks for non-standard models of natural selection

Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber, 2024, Molecular Ecology Notes

The Promise of Inferring the Past Using the Ancestral Recombination Graph

Debora Y.C. Brandt, Christian D. Huber, Charleston W.K. Chiang, Diego Ortega Del Vecchyo, 2024, Genome Biology and Evolution

Testing times: disentangling admixture histories in recent and complex demographies using ancient DNA

Matthew Williams, Pavel Flegontov, Robert Maier, Christian Huber, 2024, Genetics on p. iyae110

The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa

Raymond Tobler, Yassine Souilmi, Christian D. Huber, Nigel Bean, Chris S.M. Turney, Shane T. Grey, Alan Cooper, 2023, Proceedings of the National Academy of Sciences of the United States of America on p. e2213061120

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

Sonja Kersten, Jiyang Chang, Christian D. Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, Patricia Lang, Ulrich Lutz, Insa Hirschberg, Jens Lerchl, Aimone Porri, Yves Van de Peer, Karl Schmid, Detlef Weigel, Fernando A. Rabanal, 2023, Proceedings of the National Academy of Sciences of the United States of America

CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data

Deshan Perera, Elsa Reisenhofer, Said Hussein, Eve Higgins, Christian D. Huber, Quan Long, 2023, Methods in Ecology and Evolution on p. 2095-2109

Fluctuating selection and the determinants of genetic variation

Olivia Johnson, Raymond Tobler, Joshua Schmidt, Christian Huber, 2023, Trends in Genetics on p. 491-504

Admixture has obscured signals of historical hard sweeps in humans

Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015

smartsnp, an r package for fast multivariate analyses of big genomic data

Salvador Herrando-Pérez, Raymond Tobler, Christian D. Huber, 2021, Methods in Ecology and Evolution on p. 2084-2093

Most-Cited Papers

The inflated significance of neutral genetic diversity in conservation genetics

João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America

SweepFinder2: Increased sensitivity, robustness and flexibility

M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897

Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361

Detecting recent selective sweeps while controlling for mutation rate and background selection

Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156

Determining the factors driving selective effects of new nonsynonymous mutations

Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470

Deleterious variation shapes the genomic landscape of introgression

Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics

Gene expression drives the evolution of dominance

Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications

Similarities and differences in altitudinal versus latitudinal variation for morphological traits in drosophila melanogaster

Peter Klepsatel, Martina Gáliková, Christian D. Huber, Thomas Flatt, 2014, Evolution; international journal of organic evolution on p. 1385-1398

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

Christian D. Huber, Bernard Y. Kim, Kirk E. Lohmueller, 2020, PLoS Genetics

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9