Brad Zacharia
Associate Professor of Neurosurgery and Otolaryngology

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30 Hope Dr. Suite 200
Hershey, PA 17033 - bzacharia@pennstatehealth.psu.edu
- 717-531-8807
Huck Affiliations
Most Recent Publications
Medical Therapy Alone for Ommaya Reservoir–Associated Bacterial Meningitis: When It Works and When It Fails
Kyle Tuohy, Richard Dowd, Ayesha Ali, Aarav Badani, Krishana Sichinga, Brad E. Zacharia, Seyed Alireza Mansouri, Dawit Aregawi, Michael Glantz, 2025, Neurosurgery
Functional prediction of response to therapy prior to therapeutic intervention is associated with improved survival in patients with high-grade glioma
Aubrey Ledford, Analiz Rodriguez, Lindsay Lipinski, Ajay Abad, Robert Fenstermaker, Jeffrey Edenfield, Charles Kanos, Navid Redjal, Seyed Alireza Mansouri, Brad Zacharia, Nicholas Butowski, Jesse Liu, Seunggu J. Han, Mateo Ziu, Adam L. Cohen, Andrew J. Fabiano, Katherine Miles, Melissa Rayner, Jayla Thompson, Kelley Tollison, Pedram Azimzadeh, Lillia Holmes, Matthew Gevaert, Teresa M. DesRochers, 2024, Scientific Reports
Stereotactic radiosurgery for brain metastasis from cholangiocarcinoma
Ali Haluk Düzkalir, Yavuz Samanci, Cheng Chia Lee, Huai Che Yang, Ajay Niranjan, L. Dade Lunsford, Zhishuo Wei, Priyanka N. Srinivasan, Samantha Dayawansa, Jason P. Sheehan, Samir Patel, David Mathieu, Brad E. Zacharia, Brandon Santhumayor, Douglas Kondziolka, Selcuk Peker, 2024, Journal of Neurosurgery on p. 1324-1331
Preoperative Diagnosis of a Central Skull Base Giant Schwannoma From Tumoral Microhemorrhages Visualized on Susceptibility-Weighted Imaging.
A Krishnamoorthy, D Bailey, C Specht, Brad Zacharia, 2024, Cureus on p. e70182
Analysis of transition metals in glioblastoma tumor and plasma samples.
Ganesh Shenoy, Madison Kuhn, Aurosman Sahu, Vladimir Khristov, Madison Heebner, Hannah Wilding, Taylor Clegg, Debarati Bhanja, Quinn Wade, Laura Liermann, Dongxiang Wang, Nataliya Smith, Chachrit Khunsriraksakul, Kondaiah Palsa, Becky Slagle-Webb, Alireza Mansouri, Brad Zacharia, Elizabeth Proctor, James Connor, 2024, Journal of Clinical Oncology on p. e14029-e14029
Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application
N Mikolajewicz, P Yee, D Bhanja, M Trifoi, A Miller, P Metellus, S Bagley, L Balaj, Leonardo J.M. De MacEdo Filho, de Macedo Filho LJM, Brad E. Zacharia, Dawit Aregawi, Michael Glantz, M Weller, M Ahluwalia, T Kislinger, A Mansouri, Seyed Alireza Mansouri, 2024, Journal of Clinical Oncology on p. 1961-1974
Autologous cell immunotherapy (IGV-001) with IGF-1R antisense oligonucleotide in newly diagnosed glioblastoma patients
Ian Y. Lee, Simon Hanft, Michael Schulder, Kevin D. Judy, Eric T. Wong, J. Bradley Elder, Linton T. Evans, Mario Zuccarello, Julian Wu, Sonikpreet Aulakh, Vijay Agarwal, Rohan Ramakrishna, Brian J. Gill, Alfredo Quiñones-Hinojosa, Cameron Brennan, Brad E. Zacharia, Carlos Eduardo Silva Correia, Madhavi Diwanji, Gregory K. Pennock, Charles Scott, Raul Perez-Olle, David W. Andrews, John A. Boockvar, 2024, Future Oncology on p. 579-591
Estimating the risk of brain metastasis for patients newly diagnosed with cancer
Joseph A. Miccio, Z Tian, Sean S. Mahase, C Lin, S Choi, Brad Zacharia, J Sheehan, P Brown, D Trifiletti, J Palmer, M Wang, N Zaorsky, 2024, Communications Medicine on p. 27
Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival
G Shenoy, B Slagle-Webb, C Khunsriraksakul, B Pandya Shesh, J Luo, V Khristov, N Smith, Alireza Mansouri, Brad Zacharia, S Holder, J Lathia, J Barnholtz-Sloan, James Connor, 2024, Scientific Reports on p. 2389
Regression of Multiple Intracranial Meningiomas With Cessation of Progesterone Agonist Therapy: A Case Report.
D Bailey, K John, L Daggubati, Brad Zacharia, 2024, Cureus on p. e52479
Most-Cited Papers
Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression
Patricia Yee, Yiju Wei, Soo Kim, Tong Lu, Stephen Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, Krishnamoorthy Thamburaj, Megan M. Young, Dawit G. Aregawi, Michael J. Glantz, Brad E. Zacharia, Charles S. Specht, Hong Gang Wang, Wei Li, 2020, Nature Communications on p. 5424
Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study
C Rusthoven, M Yamamoto, D Bernhardt, D Smith, D Gao, T Serizawa, S Yomo, H Aiyama, Y Higuchi, T Shuto, A Akabane, Y Sato, A Niranjan, A Faramand, L Lunsford, James McInerney, Leonard C. Tuanquin, Brad E. Zacharia, V Chiang, C Singh, J Yu, S Braunstein, D Mathieu, C Touchette, C Lee, H Yang, A Aizer, D Cagney, M Chan, D Kondziolka, K Bernstein, J Silverman, I Grills, Z Siddiqui, J Yuan, J Sheehan, D Cordeiro, K Nosaki, T Seto, C Deibert, V Verma, S Day, L Halasz, R Warnick, D Trifiletti, J Palmer, A Attia, B Li, C Cifarelli, P Brown, J Vargo, S Combs, K Kessel, S Rieken, S Patel, M Guckenberger, N Andratschke, B Kavanagh, T Robin, 2020, JAMA oncology on p. 1028-1037
Stroke among cancer patients
Nicholas G. Zaorsky, Ying Zhang, Leila T. Tchelebi, Heath B. Mackley, Vernon M. Chinchilli, Brad E. Zacharia, 2019, Nature Communications
Frailty in Geriatric Glioblastoma Patients: A Predictor of Operative Morbidity and Outcome
Michael Cloney, Randy D'Amico, Jordan Lebovic, Matthew Nazarian, Brad E. Zacharia, Michael B. Sisti, Jeffrey N. Bruce, Guy M. McKhann, Fabio M. Iwamoto, Adam M. Sonabend, 2016, World Neurosurgery on p. 362-367
Exosomes impact survival to radiation exposure in cell line models of nervous system cancer
O Mrowczynski, A Madhankumar, Jeffrey M. Sundstrom, Yuanjun Zhao, Yuka Imamura Kawasawa, B Slagle-Webb, C Mau, R Payne, Elias B. Rizk, Brad Zacharia, James R. Connor, 2018, Oncotarget on p. 36083-36101
Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles
A Madhankumar, O Mrowczynski, S Patel, C Weston, Brad E. Zacharia, Michael J. Glantz, Christopher Siedlecki, LICHONG XU, James R. Connor, 2017, Acta Biomaterialia on p. 205-213
Blood-Brain Barrier Disruption in Neuro-Oncology: Strategies, Failures, and Challenges to Overcome
B Karmur, J Philteos, A Abbasian, Brad E. Zacharia, N Lipsman, V Levin, S Grossman, Alireza Mansouri, 2020, Frontiers in Oncology on p. 563840
The Safety of Surgery in Elderly Patients with Primary and Recurrent Glioblastoma
Randy S. D'Amico, Michael B. Cloney, Adam M. Sonabend, Brad Zacharia, Matthew N. Nazarian, Fabio M. Iwamoto, Michael B. Sisti, Jeffrey N. Bruce, Guy M. McKhann, 2015, World Neurosurgery on p. 913-919
Telemedicine for Outpatient Neurosurgical Oncology Care: Lessons Learned for the Future During the COVID-19 Pandemic
L Daggubati, D Eichberg, M Ivan, S Hanft, Alireza Mansouri, R Komotar, R D'Amico, Brad E. Zacharia, 2020, World Neurosurgery on p. e859-e863
Incidence and risk factors for preoperative deep venous thrombosis in 314 consecutive patients undergoing surgery for spinal metastasis
Brad E. Zacharia, Sweena Kahn, Evan D. Bander, Gustav Y. Cederquist, William P. Cope, Lily McLaughlin, Alexa Hijazi, Anne S. Reiner, Ilya Laufer, Mark Bilsky, 2017, Journal of Neurosurgery: Spine on p. 189-197