Bernhard Luscher
Emphasis Area Representative, Neurobiology; Professor of Biology, Biochemistry and Molecular Biology
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209 Huck Life Sciences
University Park, PA 16802 - bxl25@psu.edu
- 814-865-5549
Research Summary
Function of GABAergic synaptic transmission in health and disease, with emphasis of stress based psychiatric disorders such as major depressive disorders and mechanisms of antidepressant drug action
Huck Affiliations
- Molecular, Cellular, and Integrative Biosciences
- Neuroscience
- Neuroscience Institute
- Center for Brain, Behavior, and Cognition
- Center for Cellular Dynamics
- Center for Molecular Investigation of Neurological Disorders
Links
Most Recent Publications
GABA<sub>A</sub> receptors as targets for treating affective and cognitive symptoms of depression
Bernhard Luscher, J Maguire, U Rudolph, E Sibille, 2023, Trends in Pharmacological Sciences on p. 586-600
In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties
Anton V. Malyshev, Iuliia A. Sukhanova, Alexander S. Zlobin, Vasilina R. Gedzun, Vsevolod V. Pavshintsev, Ekaterina V. Vasileva, Arthur O. Zalevsky, Igor I. Doronin, Nikita A. Mitkin, Andrey V. Golovin, Maxim L. Lovat, Georgy I. Kovalev, Yurii A. Zolotarev, Askar R. Kuchumov, Gennady A. Babkin, Bernhard Luscher, 2021, Frontiers in Neuroscience
GABA<sub>A</sub> receptors in GtoPdb v.2021.3
Bernhard Luscher, Werner Sieghart, Uwe Rudolph, John Peters, Richard Olsen, Jeremy Lambert, Tim G. Hales, Delia Belelli, 2021, IUPHAR/BPS Guide to Pharmacology CITE
Full function of exon junction complex factor, Rbm8a, is critical for interneuron development
Colleen McSweeney, Fengping Dong, Miranda Chen, Jessica Vitale, Li Xu, Nicole Crowley, Bernhard Luscher, D Zou, Yingwei Mao, 2020, Translational Psychiatry
Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice
Sarah Jefferson, Mengyang Feng, Uree Chon, Yongsoo Kim, Bernhard Luscher, 2020, Neurobiology of Stress on p. 100238
Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Bernhard Luscher, Mengyang Feng, Sarah J. Jefferson, 2020, on p. 43-78
Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine
Mengyang Feng, Nicole A. Crowley, Akshilkumar Patel, Yao Guo, Sierra E. Bugni, Bernhard Luscher, 2019, Neuroscience on p. 109-125
Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels
Zheng Wu, Qingwei Huo, Liang Ren, Fengping Dong, Mengyang Feng, Yue Wang, Yuting Bai, Bernhard Luscher, Sheng Tian Li, Guan Lei Wang, Cheng Long, Yun Wang, Gangyi Wu, Gong Chen, 2019, Molecular Brain
Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice
Nicole A. Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44
GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Delia Belelli, Tim Hales, Jeremy Lambert, Bernhard Luscher, Richard Olsen, John Peters, Uwe Rudolph, Werner Sieghart, 2019, IUPHAR/BPS Guide to Pharmacology CITE
Most-Cited Papers
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
T. Fuchs, S. J. Jefferson, A. Hooper, P. H. Yee, J. Maguire, B. Luscher, 2017, Molecular Psychiatry on p. 920-930
GABAergic control of depression-related brain states
Bernhard Luscher, Thomas Fuchs, 2015, Advances in Pharmacology on p. 97-144
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment
Zhen Ren, Horia Pribiag, Sarah J. Jefferson, Matthew Shorey, Thomas Fuchs, David Stellwagen, Bernhard Luscher, 2016, Biological Psychiatry on p. 457-468
Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses
Borislav Dejanovic, Marcus Semtner, Silvia Ebert, Tobias Lamkemeyer, Franziska Neuser, Bernhard Lüscher, Jochen C. Meier, Guenter Schwarz, 2014, PLoS Biology on p. 1-16
Brexanolone, a neurosteroid antidepressant, vindicates the gabaergic deficit hypothesis of depression and may foster resilience.
Bernhard Lüscher, Hanns Möhler, 2019, F1000Research
DHHC7 palmitoylates glucose transporter 4 (Glut4) and regulates Glut4 membrane translocation
Keyong Du, Shoko Murakami, Yingmin Sun, Casey L. Kilpatrick, Bernhard Luscher, 2017, Journal of Biological Chemistry on p. 2979-2991
Effect of C-Terminal S-palmitoylation on D2 dopamine receptor trafficking and stability
Brittany Ebersole, Jessica Petko, Matthew Woll, Shoko Murakami, Kate Sokolina, Victoria Wong, Igor Stagljar, Bernhard Lüscher, Robert Levenson, 2015, PLoS One
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABA<sub>A</sub> receptor-deficient mice
Zhen Ren, Nadia Sahir, Shoko Murakami, Beth A. Luellen, John C. Earnheart, Rachnanjali Lal, Ju Young Kim, Hongjun Song, Bernhard Luscher, 2015, Neuropharmacology on p. 171-179
Dissociation of Golgi-associated DHHC-type zinc finger protein (GODZ)- and Sertoli cell gene with a zinc finger domain-β (SERZ-β)-mediated palmitoylation by loss of function analyses in knock-out mice
Casey L. Kilpatrick, Shoko Murakami, Mengyang Feng, Xia Wu, Rachnanjali Lal, Gong Chen, Keyong Du, Bernhard Luscher, 2016, Journal of Biological Chemistry on p. 27371-27386
Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice
Nicole A. Crowley, Sarah N. Magee, Mengyang Feng, Sarah J. Jefferson, Christian J. Morris, Nigel C. Dao, Dakota F. Brockway, Bernhard Luscher, 2019, Neuropharmacology on p. 35-44