Andrew Patterson

Professor and Huck Chair of Molecular Toxicology; Faculty Oversight, Metabolomics Core Facility

Andrew Patterson

Research Summary

The Patterson lab is focused on understanding the host-metabolite-microbiome axis

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Xenobiotic Receptor-Mediated Toxicity

GH Perdew, IA Murray, JM Peters,

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Erica Bonazzi, Alexis Bretin, Lucile Vigué, Fuhua Hao, Andrew D. Patterson, Andrew T. Gewirtz, Benoit Chassaing, 2024, Microbiome

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters, 2024, Biomolecules

Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations

Emily Van Syoc, Michelle Pistner Nixon, Justin D. Silverman, Yuhong Luo, Frank J. Gonzalez, Ilze Elbere, Janis Klovins, Andrew D. Patterson, Connie Jo Rogers, Erika Ganda, 2024, mBio

Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

Aaron L. Hecht, Lisa C. Harling, Elliot S. Friedman, Ceylan Tanes, Junhee Lee, Jenni Firrman, Fuhua Hao, Vincent Tu, Lin Shu Liu, Andrew D. Patterson, Kyle Bittinger, Mark Goulian, Gary D. Wu, 2024, Journal of Clinical Investigation

The underappreciated diversity of bile acid modifications

Ipsita Mohanty, Helena Mannochio-Russo, Joshua V. Schweer, Yasin El Abiead, Wout Bittremieux, Shipei Xing, Robin Schmid, Simone Zuffa, Felipe Vasquez, Valentina B. Muti, Jasmine Zemlin, Omar E. Tovar-Herrera, Sarah Moraïs, Dhimant Desai, Shantu Amin, Imhoi Koo, Christoph W. Turck, Itzhak Mizrahi, Penny Margaret Kris-Etherton, Kristina Petersen, Jennifer A. Fleming, Tao Huan, Andrew D. Patterson, Dionicio Siegel, Lee R. Hagey, Mingxun Wang, Allegra T. Aron, Pieter C. Dorrestein, 2024, Cell on p. 1801-1818.e20

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Debopriya Chakraborty, Denise M. Coslo, Iain Alexander Murray, Anitha Vijay, Andrew David Patterson, Gary H. Perdew, 2024, FASEB Journal

Reverse metabolomics for the discovery of chemical structures from humans

Emily C. Gentry, Stephanie L. Collins, Morgan Panitchpakdi, Pedro Belda-Ferre, Allison K. Stewart, Marvic Carrillo Terrazas, Hsueh Han Lu, Simone Zuffa, Tingting Yan, Julian Avila-Pacheco, Damian R. Plichta, Allegra T. Aron, Mingxun Wang, Alan K. Jarmusch, Fuhua Hao, Mashette Syrkin-Nikolau, Hera Vlamakis, Ashwin N. Ananthakrishnan, Brigid S. Boland, Amy Hemperly, Niels Vande Casteele, Frank J. Gonzalez, Clary B. Clish, Ramnik J. Xavier, Hiutung Chu, Erin S. Baker, Andrew D. Patterson, Rob Knight, Dionicio Siegel, Pieter C. Dorrestein, 2024, Nature on p. 419-426

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Bipin Rimal, Stephanie Collins, Megan Granda, Ceylan Tanes, Imhoi Koo, E Rocha, Sumeet Solanka, M Granda, Nushrat Hoque, Sumeet Solanki, Nushrat Hoque, Emily Gentry, Emily Gentry, Tingting Yan, Imhoi Koo, Kristopher Krausz, Erin Reilly, Fuhua Hao, Dhimant Desai, Shantu Amin, Devendra Paudel, Vishal Singh, Edson Rocha, James Coleman, Tingting Yan, Min Kim, Yatrik Shah, Frank Gonzalez, Kyle Bittinger, John Vanden Heuvel, Joseph Zackular, Kristopher Krausz, A Patterson, Dhimant Desai, Shantu Amin, James Coleman, Yatrik Shah, Jordan Bisanz, Frank Gonzalez, John P. Vanden Heuvel, John Heuvel, Gary Wu, Babette Zemel, Pieter Dorrestein, Emily E. Weinert, Andrew Patterson, 2024, Nature on p. 859-863

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Simone Zuffa, Robin Schmid, Anelize Bauermeister, Paulo Wender Paulo, Andres M. Caraballo-Rodriguez, Yasin El Abiead, Allegra T. Aron, Emily C. Gentry, Jasmine Zemlin, Michael J. Meehan, Nicole E. Avalon, Robert H. Cichewicz, Ekaterina Buzun, Marvic Carrillo Terrazas, Chia Yun Hsu, Renee Oles, Adriana Vasquez Ayala, Jiaqi Zhao, Hiutung Chu, Mirte C.M. Kuijpers, Sara L. Jackrel, Fidele Tugizimana, Lerato Pertunia Nephali, Ian A. Dubery, Ntakadzeni Edwin Madala, Eduarda Antunes Moreira, Leticia Veras Costa-Lotufo, Norberto Peporine Lopes, Paula Rezende-Teixeira, Paula C. Jimenez, Bipin Rimal, Andrew D. Patterson, Matthew F. Traxler, Rita de Cassia Pessotti, Daniel Alvarado-Villalobos, Giselle Tamayo-Castillo, Priscila Chaverri, Efrain Escudero-Leyva, Luis Manuel Quiros-Guerrero, Alexandre Jean Bory, Juliette Joubert, Adriano Rutz, Jean Luc Wolfender, Pierre Marie Allard, Andreas Sichert, Sammy Pontrelli, Benjamin S. Pullman, Nuno Bandeira, William H. Gerwick, Katia Gindro, Josep Massana-Codina, Berenike C. Wagner, Karl Forchhammer, Daniel Petras, Nicole Aiosa, Neha Garg, Manuel Liebeke, Patric Bourceau, Kyo Bin Kang, Henna Gadhavi, Luiz Pedro Sorio de Carvalho, Mariana Silva dos Santos, Alicia Isabel Pérez-Lorente, Carlos Molina-Santiago, Diego Romero, Raimo Franke, Mark Brönstrup, Arturo Vera Ponce de León, Phillip Byron Pope, Sabina Leanti La Rosa, Giorgia La Barbera, Henrik M. Roager, Martin Frederik Laursen, Fabian Hammerle, Bianka Siewert, Ursula Peintner, Cuauhtemoc Licona-Cassani, Lorena Rodriguez-Orduña, Evelyn Rampler, Felina Hildebrand, Gunda Koellensperger, Harald Schoeny, Katharina Hohenwallner, Lisa Panzenboeck, Rachel Gregor, Ellis Charles O’Neill, Eve Tallulah Roxborough, Jane Odoi, Nicole J. Bale, Su Ding, Jaap S. Sinninghe Damsté, Xue Li Guan, Jerry J. Cui, Kou San Ju, Denise Brentan Silva, Fernanda Motta Ribeiro Silva, Gilvan Ferreira da Silva, Hector H.F. Koolen, Carlismari Grundmann, Jason A. Clement, Hosein Mohimani, Kirk Broders, Kerry L. McPhail, Sidnee E. Ober-Singleton, Christopher M. Rath, Daniel McDonald, Rob Knight, Mingxun Wang, Pieter C. Dorrestein, 2024, Nature Microbiology on p. 336-345

Most-Cited Papers

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez, Changtao Jiang, 2018, Nature Medicine on p. 1919-1929

Aryl hydrocarbon receptor ligands in cancer: Friend and foe

Iain A. Murray, Andrew D. Patterson, Gary H. Perdew, 2014, Nature Reviews Cancer on p. 801-814

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

Changtao Jiang, Cen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jingwei Cai, Yunpeng Qi, Zhong Ze Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez, 2015, Journal of Clinical Investigation on p. 386-402

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

G Li, C Xie, S Lu, R Nichols, Yuan Tian, L Li, D Patel, Y Ma, C Brocker, T Yan, K Krausz, R Xiang, O Gavrilova, Andrew D. Patterson, F Gonzalez, 2017, Cell Metabolism on p. 672-685.e4

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Changtao Jiang, Cen Xie, Ying Lv, Jing Li, Kristopher W. Krausz, Jingmin Shi, Chad N. Brocker, Dhimant Desai, Shantu G. Amin, William H. Bisson, Yulan Liu, Oksana Gavrilova, Andrew D. Patterson, Frank J. Gonzalez, 2015, Nature Communications

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

P Pathak, C Xie, R Nichols, J Ferrell, S Boehme, K Krausz, Andrew D. Patterson, F Gonzalez, Chiang JYL, John Y.L. Chiang, 2018, Hepatology on p. 1574-1588

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Vishal Singh, Beng San Yeoh, Benoit Chassaing, Xia Xiao, Piu Saha, Rodrigo Aguilera Olvera, John D. Lapek, Limin Zhang, Wei Bei Wang, Sijie Hao, Michael D. Flythe, David J. Gonzalez, Patrice D. Cani, Jose R. Conejo-Garcia, Na Xiong, Mary J. Kennett, Bina Joe, Andrew D. Patterson, Andrew T. Gewirtz, Matam Vijay-Kumar, 2018, Cell on p. 679-694.e22

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

Qi Yan Ang, Margaret Alexander, John C. Newman, Yuan Tian, Jingwei Cai, Vaibhav Upadhyay, Jessie A. Turnbaugh, Eric Verdin, Kevin D. Hall, Rudolph L. Leibel, Eric Ravussin, Michael Rosenbaum, Andrew D. Patterson, Peter J. Turnbaugh, 2020, Cell on p. 1263-1275.e16

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

S Collins, Jonathan Stine, Jordan E. Bisanz, C. Denise Okafor, D Okafor, Andrew Patterson, 2022, Nature Reviews Microbiology on p. 236-247

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson, 2016, Gastroenterology on p. 845-859

News Articles Featuring Andrew Patterson

Sep 09, 2024

Refined dietary fiber may increase risk for inflammatory bowel disease

New research in mice suggests that guar gum powder — a common dietary fiber additive used in processed foods — may negatively change gut microbiome and increase risk of developing inflammatory bowel disease.

Full Article

Aug 14, 2024

Early life exposure to common chemical permanently disrupts gut microbiome

Early life exposure to "forever chemicals" in the environment permanently disrupts the gut microbiome in mice, contributing to the development of metabolic disease in later life, according to a new study led by Penn State researchers. The results suggest that human exposure to these chemicals during early childhood may be contributing to the recent epidemic of metabolic disorders, including obesity and Type 2 diabetes among adults.

Full Article

Feb 28, 2024

New role for bacterial enzyme in gut metabolism revealed

Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat.

Full Article

Feb 28, 2024

New tech harvests both magnetic and ultrasound energy to safely power medical implants

Researchers have developed an innovative dual energy harvesting technology that combines magnetic field and ultrasonic energy, their generating 300% higher power than the current state-of-the-art devices

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Feb 20, 2024

Dual-energy harvesting device could power future wireless medical implants

A new wireless charging device developed by Penn State scientists could dramatically improve powering capability for implants while still being safe for our bodies, the researchers said.

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Jan 05, 2024

The stories that defined 2023 for the One Health Microbiome Center

A list of the top 10 most popular Penn State News articles about the One Health Microbiome Center

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Nov 21, 2023

College of Ag Sciences recognizes faculty, staff for research achievements

Penn State’s College of Agricultural Sciences lauded outstanding accomplishments in research during the 2023 Research Awards Ceremony, held Nov. 1 at the Hintz Family Alumni Center on the University Park campus.

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Aug 09, 2023

College of Ag Sciences scientist receives grant to study gut homeostasis, diet

Can plants evolved to resist infection help humans do the same?

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Jul 19, 2023

Penn State researchers examine how environmental chemicals affect gut microbiome

Worldwide, high rates of obesity and other inflammatory conditions are associated with increased risk for cancer, cardiovascular disease and type 2 diabetes.

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Apr 06, 2023

Broccoli consumption protects gut lining, reduces disease, in mice

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

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Jan 12, 2023

Two College of Ag Sciences faculty among highly cited researchers in 2022

Andrew Patterson and Jonathan Lynch in Penn State’s College of Agricultural Sciences were recognized recently as highly cited researchers by the Clarivate Analytics Web of Science Group.

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Sep 13, 2022

Microbiome Center announces inaugural Interdisciplinary Innovation Fellows

The Penn State Microbiome Center has named six recipients for its inaugural Interdisciplinary Innovation Fellowships (IIF) program, which aims to promote collaborative training opportunities for center members.

Full Article

Sep 02, 2022

Metabolomics Core Facility continues to expand while pushing scientific bounds

Established nearly a decade ago, Penn State’s Metabolomics Core Facility is housed in the Huck Institutes of the Life Sciences on the University Park campus.

Full Article

Feb 09, 2021

Andrew Patterson receives Society of Toxicology Achievement Award

The Society of Toxicology has named Tombros Early Career Professor Andrew Patterson of Penn State as the recipient of its 2021 Achievement Award, recognizing his significant contributions to the field of toxicology within 15 years of obtaining the highest earned degree.

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Mar 11, 2020

Listening to your gut: A powerful new tool on the microbiome and cell metabolism

Many aspects of our lives — not only the presence or absence of certain diseases, but conditions like obesity, sleep patterns, even mood — may be determined, to a surprising extent, by the microbes living inside of us.

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Jan 21, 2020

Persistent environmental contaminant changes the gut microbiome of mice

An industrial chemical — phased out since 2002, but previously used in stain and water-repellent products and firefighting foam — alters the gut microbiome of mice and could have implications for human health, according to an international team of researchers.

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