Amie Boal
Professor of Chemistry and of Biochemistry and Molecular Biology
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326 Chemistry
University Park, PA - akb20@psu.edu
- 814-867-2863
Research Summary
The structural differences between members of large metalloenzyme superfamilies that share common features but promote different reactions or use distinct cofactors.
Huck Affiliations
Links
Most Recent Publications
Using Modelling of and Modelling For in a Teacher Professional Development Workshop to Learn how Molecular Biologist Model
Amber Cesare, Kathleen Hill, Neela Yennawar, Hemant Yennawar, Amie Boal, Cody Lloyd, Jennifer A. Gruber, Lisa Shannon, 2025,
Modulating metal-centered dimerization of a lanthanide chaperone protein for separation of light lanthanides
Wyatt B. Larrinaga, Jonathan J. Jung, Chi Yun Lin, Amie K. Boal, Joseph A. Cotruvo, 2024, Proceedings of the National Academy of Sciences of the United States of America
Optimized Substrate Positioning Enables Switches in the C−H Cleavage Site and Reaction Outcome in the Hydroxylation−Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase
Eliott Wenger, Ryan Martinie, Richiro Ushimary, Richiro Ushimaru, Christopher Pollock, D Sil, Aaron Li, Nhi Hoang, Gavin Palowitch, Brandt Graham, Irene Schaperdoth, Evan Burke, A Maggiolo, Wei Chang, B Allen, Carsten Krebs, Alexey Silakov, Amie Kathleen Boal, Joseph Bollinger, 2024, Journal of the American Chemical Society on p. 24271-24287
Methods for Biophysical Characterization of SznF, a Member of the Heme-Oxygenase-Like Diiron Oxidase/Oxygenase Superfamily
Molly McBride, Sarah Pope, Mrutyunjay Nair, D Sil, Xavier Salas-Solá, Carsten Krebs, J. Martin Bollinger, Amie K. Boal, 2023, on p. 123-154
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
J Mattocks, J Jung, C Lin, Z Dong, Neela Yennawar, E Featherston, E Featherson, C Kang-Yun, T Hamilton, D Park, Amie Boal, Joseph A. Cotruvo, J Cotruvo Jr., J Cotruvo, Jr, 2023, Nature on p. 87-93
Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States
Jeffrey Slater, Chi Lin, M Neugebauer, Monica Neugebauer, M McBride, D Sil, Molly McBride, C Lin, D Sil, Mrutyunjay Nair, B Katch, Amie Boal, Bryce Katch, M Chang, Michelle Chang, A Silakov, C Krebs, Alexey Silakov, J Bollinger Jr., Joseph Bollinger, Carsten Krebs, 2023, Biochemistry on p. 2480-2491
Discovery, structure and mechanism of a tetraether lipid synthase
Cody T. Lloyd, David F. Iwig, Bo Wang, Matteo Cossu, William W. Metcalf, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 197-203
Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes
Vivian Robert Jeyachandran, Amie K. Boal, 2022, Current Opinion in Chemical Biology
Structure of a B<sub>12</sub>-dependent radical SAM enzyme in carbapenem biosynthesis
Hayley L. Knox, Erica K. Sinner, Craig A. Townsend, Amie K. Boal, Squire J. Booker, 2022, Nature on p. 343-348
Structural Basis for an Unprecedented Enzymatic Alkylation in Cylindrocyclophane Biosynthesis
Nathaniel R. Braffman, Terry B. Ruskoski, Katherine M. Davis, Nathaniel R. Glasser, Cassidy Johnson, C. Denise Okafor, Amie K. Boal, Emily P. Balskus, 2022, eLife
Most-Cited Papers
Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers
Franklin D. Fuller, Sheraz Gul, Ruchira Chatterjee, E. Sethe Burgie, Iris D. Young, Hugo Lebrette, Vivek Srinivas, Aaron S. Brewster, Tara Michels-Clark, Jonathan A. Clinger, Babak Andi, Mohamed Ibrahim, Ernest Pastor, Casper De Lichtenberg, Rana Hussein, Christopher J. Pollock, Miao Zhang, Claudiu A. Stan, Thomas Kroll, Thomas Fransson, Clemens Weninger, Markus Kubin, Pierre Aller, Louise Lassalle, Philipp Bräuer, Mitchell D. Miller, Muhamed Amin, Sergey Koroidov, Christian G. Roessler, Marc Allaire, Raymond G. Sierra, Peter T. Docker, James M. Glownia, Silke Nelson, Jason E. Koglin, Diling Zhu, Matthieu Chollet, Sanghoon Song, Henrik Lemke, Mengning Liang, Dimosthenis Sokaras, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Amie K. Boal, J. Martin Bollinger, Carsten Krebs, Martin Högbom, George N. Phillips, Richard D. Vierstra, Nicholas K. Sauter, Allen M. Orville, Jan Kern, Vittal K. Yachandra, Junko Yano, 2017, Nature Methods on p. 443-449
Structural basis for halogenation by iron-and 2-oxo-glutarate-dependent enzyme WelO5
Andrew J. Mitchell, Qin Zhu, Ailiena O. Maggiolo, Nikhil R. Ananth, Matthew L. Hillwig, Xinyu Liu, Amie K. Boal, 2016, Nature Chemical Biology on p. 636-640
Visualizing the reaction cycle in an Iron(II)- and 2-(Oxo)-glutarate-dependent hydroxylase
Andrew J. Mitchell, Noah P. Dunham, Ryan J. Martinie, Jonathan A. Bergman, Christopher J. Pollock, Kai Hu, Benjamin D. Allen, Wei Chen Chang, Alexey Silakov, J. Martin Bollinger, Carsten Krebs, Amie K. Boal, 2017, Journal of the American Chemical Society on p. 13830-13836
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
Tai L. Ng, Roman Rohac, Andrew J. Mitchell, Amie K. Boal, Emily P. Balskus, 2019, Nature on p. 94-99
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance
Noah P. Dunham, Wei Chen Chang, Andrew J. Mitchell, Ryan J. Martinie, Bo Zhang, Jonathan A. Bergman, Lauren J. Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K. Boal, J. Martin Bollinger, 2018, Journal of the American Chemical Society on p. 7116-7126
AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress
Yu Liu, Matthew Fares, Noah P. Dunham, Zi Gao, Kun Miao, Xueyuan Jiang, Samuel S. Bollinger, Amie K. Boal, Xin Zhang, 2017, Angewandte Chemie - International Edition on p. 8672-8676
Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer
J Mattocks, J Jung, C Lin, Z Dong, Neela Yennawar, E Featherston, E Featherson, C Kang-Yun, T Hamilton, D Park, Amie Boal, Joseph A. Cotruvo, J Cotruvo Jr., J Cotruvo, Jr, 2023, Nature on p. 87-93
Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond
J. Martin Bollinger, Wei Chen Chang, Megan L. Matthews, Ryan J. Martinie, Amie K. Boal, Carsten Krebs, 2015, on p. 95-122
The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification
Yu Liu, Kun Miao, Noah P. Dunham, Hongbin Liu, Matthew Fares, Amie K. Boal, Xiaosong Li, Xin Zhang, 2017, Biochemistry on p. 1585-1595
Structure-Guided Reprogramming of a Hydroxylase to Halogenate Its Small Molecule Substrate
Andrew J. Mitchell, Noah P. Dunham, Jonathan A. Bergman, Bo Wang, Qin Zhu, Wei Chen Chang, Xinyu Liu, Amie K. Boal, 2017, Biochemistry on p. 441-444
News Articles Featuring Amie Boal
Oct 29, 2024
Bacterial protein discovered, engineered to better separate rare earth metals
A newly discovered protein naturally houses an unusual binding site that can differentiate between rare earth elements, and researchers at Penn State have made it even better.
Full Article
May 31, 2023
A protein mines, sorts rare earths better than humans, paving way for green tech
Rare earth elements, like neodymium and dysprosium, are a critical component to almost all modern technologies, from smartphones to hard drives, but they are notoriously hard to separate from the Earth’s crust and from one another.
Full Article
Aug 31, 2022
Boal recieves Early Career Award from Society of Biological Inorganic Chemistry
Amie Boal, professor of chemistry and of biochemistry and molecular biology, has been named a recipient of the 2022 Early Career Award from the International Society for Biological Inorganic Chemistry (SBIC), an organization dedicated to advancing research and promoting understanding of biological inorganic chemistry within academia, industry, and the general public
Full Article
Aug 22, 2022
Revealed missing step in lipid formation could enable detection of past climate
The missing step in the formation of a lipid molecule that allows certain single-celled organisms to survive the most extreme environments on Earth has now been deciphered.
Full Article