Adam Glick

Emphasis Area Representative, Cancer Biology; Professor of Molecular Toxicology and Carcinogenesis;

Adam Glick

Research Summary

The role of Transforming Growth Factor-beta in cutaneous inflammation and cancer development, and how the immune system responds to epithelial cells with activated oncogenes such as Ras. Signaling pathways that regulate senescence of premalignant epithelial cells and how cells escape from oncogene-induced senescence.

Huck Affiliations

Links

Publication Tags

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Keratinocytes Neoplasms Proteins Apoptosis Genes Peptides Endoplasmic Reticulum Stress Skin Unfolded Protein Response Enzymes Esters Aryl Hydrocarbon Receptors Drug Delivery Systems Inositol Nanoparticles Protein Cell Death Tumors Cells Gene Expression Endoplasmic Reticulum Epithelial Cells Aromatic Hydrocarbon Receptor Microrna Hydrocarbon

Most Recent Publications

RAS-activated PI3K/AKT signaling sustains cellular senescence via P53/P21 axis in experimental models of psoriasis

Laura Mercurio, Jacob Bailey, Adam Bleier Glick, Elena Dellambra, Claudia Scarponi, Sabatino Pallotta, Cristina Albanesi, Stefania Madonna, 2024, Journal of Dermatological Science on p. 21-32

Activation of Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) in Keratinocytes by Endogenous Fatty Acids

Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters, 2024, Biomolecules

IRE1alpha Regulates ROS and Immune Responses after UV Irradiation

Adam Glick, 2024, Redox Experimental Medicine

Near-Infrared Induced miR-34a Delivery from Nanoparticles in Esophageal Cancer Treatment

Nick Alden, Tyus Yeingst, Hanna Pfeiffer, Nazmiye Celik, Julien Arrizabalaga, Angelica Helton, Yiming Liu, Douglas B. Stairs, Adam B. Glick, Neerav Goyal, Daniel J. Hayes, 2024, Advanced healthcare materials

Biology of Stress Responses in Aging.

M Maragkakis, S Malla, M Hatzoglou, A Trifunovic, Adam Glick, T Finkel, V Longo, S Kaushik, P Muñoz-Cánoves, G Lithgow, N Naidoo, L Booth, M Payea, A Herman, R de Cabo, D Wilson, L Ferrucci, M Gorospe, 2023, Aging Biology

The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus

F Chalmers, S Mogre, B Rimal, J Son, Andrew D. Patterson, Douglas B. Stairs, Adam Glick, 2022, Developmental Biology on p. 59-70

TGFβ1 regulates HRas-mediated activation of IRE1α through the PERK-RPAP2 axis in keratinocytes

Saie Mogre, Nicholas Blazanin, Hailey Walsh, Jack Ibinson, Chase Minnich, Chih Chi Andrew Hu, Adam B. Glick, 2022, Molecular Carcinogenesis on p. 958-971

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

N Alden, J Arrizabalaga, Y Liu, Shantu Amin, Krishne Gowda, S Yao, Marco Archetti, Adam Glick, Daniel J. Hayes, 2022, Langmuir on p. 9833-9843

The Endoplasmic Reticulum Stress Sensor IRE1α Regulates the UV DNA Repair Response through the Control of Intracellular Calcium Homeostasis

Jeongin Son, Saie Mogre, Fiona E. Chalmers, Jack Ibinson, Stephen Worrell, Adam B. Glick, 2022, Journal of Investigative Dermatology on p. 1682-1691.e7

Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration

Fiona E. Chalmers, Justyn E. Dusold, Javed A. Shaik, Hailey A. Walsh, Adam B. Glick, 2022, Developmental Biology on p. 9-23

Most-Cited Papers

Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation

Ellen H. Van Den Bogaard, Michael A. Podolsky, Jos P. Smits, Xiao Cui, Christian John, Krishne Gowda, Dhimant Desai, Shantu G. Amin, Joost Schalkwijk, Gary H. Perdew, Adam B. Glick, 2015, Journal of Investigative Dermatology on p. 1320-1328

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras

Nicholas Blazanin, Jeongin Son, Alayna B. Craig-Lucas, Christian L. John, Kyle J. Breech, Michael A. Podolsky, Adam B. Glick, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 9900-9905

The nuclear receptor peroxisome proliferator-activated receptor-β/ δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress

Bokai Zhu, Christina H. Ferry, Lauren K. Markell, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, Jeffrey M. Peters, 2014, Journal of Biological Chemistry on p. 20102-20119

PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

B. Zhu, C. H. Ferry, N. Blazanin, M. T. Bility, C. Khozoie, B. H. Kang, A. B. Glick, F. J. Gonzalez, J. M. Peters, 2014, Oncogene on p. 5348-5359

Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks

Janna Sloand, Janna Sloand^, Eric Cook, Theodore Nguyen, Scott A. Zinck, Tawanda Zimudzi, Erik C. Cook, Scott Zinck, S Showalter, Tawanda J. Zimudzi, Scott Schowalter, Scott A. Showalter, Julianna Simon, S Medina, Adam B. Glick, Julianna Simon, Scott Medina*, 2020, ACS Nano on p. 4061-4073

Ah receptor activation potentiates neutrophil chemoattractant (C-X-C Motif) ligand 5 expression in keratinocytes and skin

K Smith, J Boyer, G Muku, I Murray, Krishne Gowda, D Desai, S Amin, A Glick, Gary Perdew, 2017, Toxicological Sciences on p. 83-94

Photocontrolled miR-148b nanoparticles cause apoptosis, inflammation and regression of Ras induced epidermal squamous cell carcinomas in mice

Yiming Liu, Jacob T. Bailey, Mohammad Abu-Laban, Shue Li, Cong Chen, Adam B. Glick, Daniel J. Hayes, 2020, Biomaterials

Tumor-promoting role of TGFß1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells

Anand Ravindran, Javed Mohammed, Andrew J. Gunderson, Xiao Cui, Adam B. Glick, 2014, Carcinogenesis on p. 959-966

The multiple roles of the unfolded protein response regulator IRE1α in cancer

Fiona Chalmers, Saie Mogre, Jeongin Son, Nicholas Blazanin, Adam B. Glick, 2019, Molecular Carcinogenesis on p. 1623-1630

Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers

M Aronson, Matthew Aronson^, Erika Dahl, J Halle, Jacob Halle^, Andrew Simonson^, A Simonson, Rose Gogal, Adam B. Glick, K Aird, Scott H. Medina, 2020, Cellular and Molecular Bioengineering on p. 447-461