Kumble Sandeep Prabhu

Professor of Immunology and Molecular Toxicology

Kumble Sandeep Prabhu

Research Summary

Molecular mechanisms by which bioactives such as selenium, omega-3 fatty acids, and other products of natural origin alter the host response and immune function in inflammation and cancer

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model

Bei Jia, Chenchen Zhao, Kentaro Minagawa, Hiroko Shike, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Shin Mineishi, Ming Wang, Todd D. Schell, K. Sandeep Prabhu, Robert F. Paulson, Yi Zhang, Leonard D. Shultz, Hong Zheng, 2023, Journal of Immunology on p. 1426-1437

The selenoprotein P-LRP5/6-WNT3A complex promotes tumorigenesis in sporadic colorectal cancer

K. Sandeep Prabhu, 2023, Journal of Clinical Investigation

Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair

Shaneice K. Nettleford, Chang Liao, Sarah P. Short, Randall M. Rossi, Vishal Singh, K. Sandeep Prabhu, 2023, Antioxidants

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Sougat Misra, Tai-Jung Lee, Molly Hall, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, A Patterson, Randall Rossi, Molly Hall, Istvan Albert, others, K Prabhu, 2023, Redox Biology on p. 102571

The role of selenoproteins in neutrophils during inflammation

Tai Jung Lee, Shaneice K. Nettleford, Allison McGlynn, Bradley A. Carlson, Girish S. Kirimanjeswara, K. Sandeep Prabhu, 2022, Archives of Biochemistry and Biophysics

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder

Nidhi Girdhar, Heena Kansal, Kranti Garg, Siddharth Sharma, K. Sandeep Prabhu, Vishal Chopra, Alexey A. Tinkov, Anatoly V. Skalny, N. Tejo Prakash, 2022, Biological Trace Element Research on p. 4949-4954

Interleukin-4 treatment reduces leukemia burden in acute myeloid leukemia

F Qian, B Arner, Kathleen M. Kelly, C Annageldiyev, Arati Sharma, David F. Claxton, Robert F. Paulson, K Prabhu, 2022, FASEB Journal on p. e22328

A novel clinically relevant graft-versus-leukemia model in humanized mice

B Jia, C Zhao, Michael Bayerl, Hiroko Shike, David F. Claxton, W Ehmann, Shin Mineishi, Todd D. Schell, P Zheng, Y Zhang, L Shultz, K. Sandeep Prabhu, Robert Paulson, Hong Zheng, 2021, Journal of Leukocyte Biology on p. 427-437

Selenium-dependent metabolic reprogramming during inflammation and resolution

A Korwar, A Hossain, T Lee, Ashley Shay, V Basrur, K Conlon, Philip B. Smith, B Carlson, Howard M. Salis, Andrew D. Patterson, K. Sandeep Prabhu, 2021, Journal of Biological Chemistry on p. 100410

Macrophage Selenoproteins Restrict Intracellular Replication of Francisella tularensis and Are Essential for Host Immunity

Rachel Markley, Katherine Restori, Bhuvana Katkere, Sarah Sumner, McKayla Nicol, Anastasia Tyryshkina, Shaneice Nettleford, David Williamson, David Place, Kalyan Dewan, Ashley Shay, others, Bradley Carlson, Santhosh Girirajan, K. Sandeep Prabhu, Girish S. Kirimanjeswara, 2021, Frontiers in Immunology on p. 701341

Most-Cited Papers

Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh, Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, K. Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang, 2016, Journal of Biological Chemistry on p. 24036-24040

Selenium and inflammatory bowel disease

A Kudva, Ashley Shay, K. Sandeep Prabhu, 2015, American Journal of Physiology on p. G71-G77

Crucial role of macrophage selenoproteins in experimental colitis

Naveen Kaushal, Avinash K. Kudva, Andrew D. Patterson, Christopher Chiaro, Mary J. Kennett, Dhimant Desai, Shantu Amin, Bradley A. Carlson, Margherita T. Cantorna, K. Sandeep Prabhu, 2014, Journal of Immunology on p. 3683-3692

Selenium

K. Sandeep Prabhu, Xin Gen Lei, 2016, Advances in nutrition (Bethesda, Md.) on p. 415-417

Selenium and selenoproteins in gut inflammation—A review

Shaneice K. Nettleford, K. Sandeep Prabhu, 2018, Antioxidants

Epigenetic regulation of inflammatory gene expression in macrophages by selenium

Vivek Narayan, Kodihalli C. Ravindra, Chang Liao, Naveen Kaushal, Bradley A. Carlson, K. Sandeep Prabhu, 2015, Nutrition Reports International on p. 138-145

The microbiome and obesity-An established risk for certain types of cancer

Connie J. Rogers, Kumble Sandeep Prabhu, Matam Vijay-Kumar, 2014, Cancer Journal from Scientific American on p. 176-180

Selenium and selenoproteins in prostanoid metabolism and immunity

F Qian, Sougat Misra, K. Sandeep Prabhu, 2019, Critical Reviews in Biochemistry and Molecular Biology on p. 484-516

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

L Bennett, C Liao, M Quickel, B Yeoh, M Vijay-Kumar, Pamela Hankey-Giblin, K. Sandeep Prabhu, Robert Paulson, 2019, Science's STKE : signal transduction knowledge environment

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia

C Liao, K. Sandeep Prabhu, K Prabhu, Robert Paulson, 2018, Blood on p. 2580-2593