Grayson Sipe

Assistant Professor of Biology

Grayson Sipe

Research Summary

Studying the molecular and cellular mechanisms that drive shifts in arousal, which are crucial for understanding maladaptive arousal in neuropsychiatric disorders such as anxiety and addiction.

Huck Graduate Students

Huck Affiliations

Links

Most Recent Publications

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing.

J Park, Grayson Sipe, X Tang, P Ojha, G Fernandes, Y Leow, C Zhang, Y Osako, A Natesan, G Drummond, R Jaenisch, M Sur, 2024, bioRxiv : the preprint server for biology

Cortical norepinephrine-astrocyte signaling critically mediates learned behavior.

G Drummond, A Natesan, M Celotto, J Shih, P Ojha, Y Osako, J Park, Grayson Sipe, K Jenks, V Breton-Provencher, P Simpson, S Panzeri, M Sur, 2024, bioRxiv : the preprint server for biology

A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging

Anagha Kalelkar, Grayson Sipe, Ana Raquel Castro E Costa, Ilka M. Lorenzo, My Nguyen, Ivan Linares-Garcia, Elena Vazey, Rafiq Huda, 2024, Neuropharmacology

Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.

Y Yang, D Leopold, J Duyn, Grayson Sipe, X Liu, 2023, bioRxiv : the preprint server for biology

Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex

Grayson O. Sipe, Jeremy Petravicz, Rajeev V. Rikhye, Rodrigo Garcia, Nikolaos Mellios, Mriganka Sur, 2021, GLIA on p. 1723-1735

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

Rafiq Huda, Grayson O. Sipe, Vincent Breton-Provencher, K. Guadalupe Cruz, Gerald N. Pho, Elie Adam, Liadan M. Gunter, Austin Sullins, Ian R. Wickersham, Mriganka Sur, 2020, Nature Communications

Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex (Nature Neuroscience, (2019), 22, 11, (1782-1792), 10.1038/s41593-019-0514-0)

Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2020, Nature Neuroscience on p. 152

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2019, Nature Neuroscience on p. 1782-1792

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

G. O. Sipe, R. L. Lowery, M. Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska, 2016, Nature Communications

Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses

Crystal L. Lantz, Grayson O. Sipe, Elissa L. Wong, Ania K. Majewska, Alexandre E. Medina, 2015, Alcoholism: Clinical and Experimental Research on p. 1434-1442

Most-Cited Papers

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

G. O. Sipe, R. L. Lowery, M. Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska, 2016, Nature Communications

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex

Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2019, Nature Neuroscience on p. 1782-1792

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

Rafiq Huda, Grayson O. Sipe, Vincent Breton-Provencher, K. Guadalupe Cruz, Gerald N. Pho, Elie Adam, Liadan M. Gunter, Austin Sullins, Ian R. Wickersham, Mriganka Sur, 2020, Nature Communications

Fluoxetine modulates breast cancer metastasis to the brain in a murine model

Yuriy Shapovalov, Martha Zettel, Sara C. Spielman, Stacy A. Amico-Ruvio, Emily A. Kelly, Grayson O. Sipe, Ian M. Dickerson, Ania K. Majewska, Edward B. Brown, 2014, BMC Cancer

Effects of Developmental Alcohol Exposure on Potentiation and Depression of Visual Cortex Responses

Crystal L. Lantz, Grayson O. Sipe, Elissa L. Wong, Ania K. Majewska, Alexandre E. Medina, 2015, Alcoholism: Clinical and Experimental Research on p. 1434-1442

Astrocyte glutamate uptake coordinates experience-dependent, eye-specific refinement in developing visual cortex

Grayson O. Sipe, Jeremy Petravicz, Rajeev V. Rikhye, Rodrigo Garcia, Nikolaos Mellios, Mriganka Sur, 2021, GLIA on p. 1723-1735

Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex (Nature Neuroscience, (2019), 22, 11, (1782-1792), 10.1038/s41593-019-0514-0)

Rianne D. Stowell, Grayson O. Sipe, Ryan P. Dawes, Hanna N. Batchelor, Katheryn A. Lordy, Brendan S. Whitelaw, Mark B. Stoessel, Jean M. Bidlack, Edward Brown, Mriganka Sur, Ania K. Majewska, 2020, Nature Neuroscience on p. 152

A paradigm for ethanol consumption in head-fixed mice during prefrontal cortical two-photon calcium imaging

Anagha Kalelkar, Grayson Sipe, Ana Raquel Castro E Costa, Ilka M. Lorenzo, My Nguyen, Ivan Linares-Garcia, Elena Vazey, Rafiq Huda, 2024, Neuropharmacology

Intrinsic forebrain arousal dynamics governs sensory stimulus encoding.

Y Yang, D Leopold, J Duyn, Grayson Sipe, X Liu, 2023, bioRxiv : the preprint server for biology

Cortical norepinephrine-astrocyte signaling critically mediates learned behavior.

G Drummond, A Natesan, M Celotto, J Shih, P Ojha, Y Osako, J Park, Grayson Sipe, K Jenks, V Breton-Provencher, P Simpson, S Panzeri, M Sur, 2024, bioRxiv : the preprint server for biology