Dajiang Liu
Co-Chair, Intercollege Graduate Degree Program in Bioinformatics and Genomics; Professor of Public Health Sciences and Biochemistry and Molecular Biology
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R125 Public Health Sciences
Hershey, PA - dxl46@psu.edu
- 717-531-4178
Research Summary
Developing statistical and AI methods and experimental approaches to integrate multi-omics data with GWAS to study host x microbiome interaction, Alzheimer's diseases, smoking and drinking addiction, and lupus in diverse populations.
Huck Graduate Students
Huck Affiliations
Links
Most Recent Publications
Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu, Bibo Jiang, 2024, Nature Communications
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H.Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Maciej Tomaszewski, 2024, Nature Communications
Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan
Daniel McGuire, Havell Markus, Lina Yang, Jingyu Xu, Austin Montgomery, Arthur Berg, Qunhua Li, Laura Carrel, Dajiang J. Liu, Bibo Jiang, 2024, Nature Communications
Native American genetic ancestry and pigmentation allele contributions to skin color in a Caribbean population
Khai C. Ang, Victor A. Canfield, Tiffany C. Foster, Thaddeus D. Harbaugh, Kathryn A. Early, Rachel L. Harter, Katherine P. Reid, Shou Ling Leong, Yuka I. Kawasawa, Dajiang J. Liu, John W. Hawley, Keith C. Cheng, 2023, eLife
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
C Khunsriraksakul, Q Li, H Markus, M Patrick, R Sauteraud, D McGuire, Xingyan Wang, C Wang, L Wang, S Chen, G Shenoy, B Li, X Zhong, Nancy J. Olsen, Laura Carrel, L Tsoi, Bibo Jiang, Dajiang J. Liu, 2023, Nature Communications on p. 668
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Fang Chen, Xingyan Wang, Seon Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D.D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel I. Chasman, Sameer Chavan, Yii Der I. Chen, Lee Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L.R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I. Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi’a Sefuiva Reupena, Stephen S. Rich, Jerome I. Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H.H. Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu, 2023, Nature Genetics on p. 291-300
Association of surfactant protein A2 with acute respiratory failure in children
Lucy Emery, Elizabeth Kane, Keenan Anderson-Fears, Dajiang Liu, Joanna Floros, Chintan K. Gandhi, 2023, Pediatrics International
Genetic diversity fuels gene discovery for tobacco and alcohol use
Gretchen R.B. Saunders, Xingyan Wang, Fang Chen, Seon Kyeong Jang, Mengzhen Liu, Chen Wang, Shuang Gao, Yu Jiang, Chachrit Khunsriraksakul, Jacqueline M. Otto, Clifton Addison, Masato Akiyama, Christine M. Albert, Fazil Aliev, Alvaro Alonso, Donna K. Arnett, Allison E. Ashley-Koch, Aneel A. Ashrani, Kathleen C. Barnes, R. Graham Barr, Traci M. Bartz, Diane M. Becker, Lawrence F. Bielak, Emelia J. Benjamin, Joshua C. Bis, Gyda Bjornsdottir, John Blangero, Eugene R. Bleecker, Jason D. Boardman, Eric Boerwinkle, Dorret I. Boomsma, Meher Preethi Boorgula, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Daniel I. Chasman, Sameer Chavan, Yii Der Ida Chen, Zhengming Chen, Iona Cheng, Michael H. Cho, Hélène Choquet, John W. Cole, Marilyn C. Cornelis, Francesco Cucca, Joanne E. Curran, Mariza de Andrade, Danielle M. Dick, Bibo Jiang, Dajiang J. Liu, 2022, Nature on p. 720-724
Analysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
Galen F. Gao, Dajiang Liu, Xiaowei Zhan, Bo Li, 2022, BMC Biology
RNAseq reveals extensive metabolic disruptions in the sensitive SF-295 cell line treated with schweinfurthins
J. S. Weissenrieder, J. D. Weissenkampen, J. L. Reed, M. V. Green, C. Zheng, J. D. Neighbors, D. J. Liu, Raymond J. Hohl, 2022, Scientific Reports
Most-Cited Papers
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Mengzhen Liu, Yu Jiang, Robbee Wedow, Yue Li, David M. Brazel, Fang Chen, Gargi Datta, Jose Davila-Velderrain, Daniel McGuire, Chao Tian, Xiaowei Zhan, Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Bethann S. Hromatka, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Matthew H. McIntyre, Joanna L. Mountain, Carrie A.M. Northover, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, Steven J. Pitts, Amy Mitchell, Anne Heidi Skogholt, Bendik S. Winsvold, Børge Sivertsen, Eystein Stordal, Gunnar Morken, Håvard Kallestad, Ingrid Heuch, John Anker Zwart, Katrine Kveli Fjukstad, Linda M. Pedersen, Maiken Elvestad Gabrielsen, Marianne Bakke Johnsen, Dajiang Liu, 2019, Nature Genetics on p. 237-244
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William F. Hancock-Cerutti, John S. Millar, Marina Cuchel, Stephanie DerOhannessian, Anatol Kontush, Praveen Surendran, Danish Saleheen, Stella Trompet, J. Wouter Jukema, Anton De Craen, Panos Deloukas, Naveed Sattar, Ian Ford, Chris Packard, Abdullah Al Shafi Majumder, Dewan S. Alam, Emanuele Di Angelantonio, Goncalo Abecasis, Rajiv Chowdhury, Jeanette Erdmann, Børge G. Nordestgaard, Sune F. Nielsen, Anne Tybjærg-Hansen, Frikke Schmidt Ruth Frikke Schmidt, Kari Kuulasmaa, Dajiang J. Liu, Markus Perola, Stefan Blankenberg, Veikko Salomaa, Satu Männistö, Philippe Amouyel, Dominique Arveiler, Jean Ferrieres, Martina Möller-Nurasyid, Marco Ferrario, Frank Kee, Cristen J. Willer, Nilesh Samani, Heribert Schunkert, Adam S. Butterworth, Joanna M.M. Howson, Gina M. Peloso, Nathan O. Stitziel, John Danesh, Sekar Kathiresan, Daniel J. Rader, 2016, Science on p. 1166-1171
Rare and low-frequency coding variants alter human adult height
Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R. Wood, Troels R. Kjaer, Rebecca S. Fine, Yingchang Lu, Claudia Schurmann, Heather M. Highland, Sina Rüeger, Gudmar Thorleifsson, Anne E. Justice, David Lamparter, Kathleen E. Stirrups, Valérie Turcot, Kristin L. Young, Thomas W. Winkler, Tõnu Esko, Tugce Karaderi, Adam E. Locke, Nicholas G.D. Masca, Maggie C.Y. Ng, Poorva Mudgal, Manuel A. Rivas, Sailaja Vedantam, Anubha Mahajan, Xiuqing Guo, Goncalo Abecasis, Katja K. Aben, Linda S. Adair, Dewan S. Alam, Eva Albrecht, Kristine H. Allin, Matthew Allison, Philippe Amouyel, Emil V. Appel, Dominique Arveiler, Folkert W. Asselbergs, Paul L. Auer, Beverley Balkau, Bernhard Banas, Lia E. Bang, Marianne Benn, Sven Bergmann, Lawrence F. Bielak, Matthias Blüher, Heiner Boeing, Eric Boerwinkle, Dajiang Liu, 2017, Nature on p. 186-190
Exome-wide association study of plasma lipids in >300,000 individuals
Dajiang J. Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele DI Angelantonio, Dominique Arveiler, Themistocles L. Assimes, Paul L. Auer, Usman Baber, Christie M. Ballantyne, Lia E. Bang, Marianne Benn, Joshua C. Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P. Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Y. Eugene Chen, Yii Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y. Chu, John M. Connell, Francesco Cucca, L. Adrienne Cupples, Scott M. Damrauer, Gail Davies, Ian J. Deary, George Dedoussis, Joshua C. Denny, Anna Dominiczak, Marie Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Toñu Esko, Aliki Eleni Farmaki, Mary F. Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W. Franks, Timothy M. Frayling, Ruth Frikke-Schmidt, Lars G. Fritsche, Philippe Frossard, Valentin Fuster, Santhi K. Ganesh, Wei Gao, Melissa E. Garcia, Christian Gieger, Franco Giulianini, Mark O. Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L. Grove, Vilmundur Gudnason, Torben Hansen, Tamara B. Harris, Caroline Hayward, Joel N. Hirschhorn, Oddgeir L. Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U. Jackson, Johanna Jakobsdottir, Marjo Riitta Jarvelin, Gorm B. Jensen, Marit E. Jørgensen, J. Wouter Jukema, Johanne M. Justesen, Pia R. Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V. Khera, Derek Klarin, Heikki A. Koistinen, Jaspal S. Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J. Launer, Torsten Lauritzen, David C. MLiewald, Li An Lin, Allan Linneberg, Ruth J.F. Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K. Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas G.D. Masca, Andrea Maschio, James B. Meigs, Olle Melander, Andres Metspalu, Andrew P. Morris, Alanna C. Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B. Munroe, Matt J. Neville, Sune F. Nielsen, Jonas B. Nielsen, Børge G. Nordestgaard, Jose M. Ordovas, Roxana Mehran, Christoper J. O'Donnell, Marju Orho-Melander, Cliona M. Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin N.A. Palmer, Dorota Pasko, Aniruddh P. Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M. Psaty, Daniel J. Rader, Asif Rasheed, Rainer Rauramaa, Dermot F. Reilly, Alex P. Reiner, Frida Renström, Stephen S. Rich, Paul M. Ridker, John D. Rioux, Neil R. Robertson, Dan M. Roden, Jerome I. Rotter, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Serena Sanna, Naveed Sattar, Ellen M. Schmidt, Robert A. Scott, Peter Sever, Raquel S. Sevilla, Christian M. Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S. Small, Albert V. Smith, Blair H. Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D. Spector, Elizabeth K. Speliotes, John M. Starr, Kathleen E. Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M. Stringham, Praveen Surendran, Hayato Tada, Alan R. Tall, Hua Tang, Jean Claude Tardif, Kent D. Taylor, Stella Trompet, Philip S. Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R.Van Zuydam, Anette Varbo, Tibor V. Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J. Wareham, Helen R. Warren, Peter E. Weeke, Joshua Weinstock, Jennifer Wessel, James G. Wilson, Peter W.F. Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S. Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Joanna M.M. Howson, John Danesh, Mark I. McCarthy, Chad A. Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J. Willer, Sekar Kathiresan, 2017, Nature Genetics on p. 1758-1766
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
Derek Klarin, Scott M. Damrauer, Kelly Cho, Yan V. Sun, Tanya M. Teslovich, Jacqueline Honerlaw, David R. Gagnon, Scott L. DuVall, Jin Li, Gina M. Peloso, Mark Chaffin, Aeron M. Small, Jie Huang, Hua Tang, Julie A. Lynch, Yuk Lam Ho, Dajiang J. Liu, Connor A. Emdin, Alexander H. Li, Jennifer E. Huffman, Jennifer S. Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M. Neale, Aliya Naheed, Amit V. Khera, John Danesh, Kyong Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E. Dewey, David J. Carey, John Concato, J. Michael Gaziano, Christopher J. O’Donnell, Philip S. Tsao, Sekar Kathiresan, Daniel J. Rader, Peter W.F. Wilson, Themistocles L. Assimes, 2018, Nature Genetics on p. 1514-1523
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, N. William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A. Jensen, Yao Hu, Shaofeng Huo, Kurt K. Lohman, Weihua Zhang, James P. Cook, Bram Peter Prins, Jason Flannick, Niels Grarup, Vassily Vladimirovich Trubetskoy, Jasmina Kravic, Young Jin Kim, Denis V. Rybin, Hanieh Yaghootkar, Martina Müller-Nurasyid, Karina Meidtner, Ruifang Li-Gao, Tibor V. Varga, Jonathan Marten, Jin Li, Albert Vernon Smith, Ping An, Symen Ligthart, Stefan Gustafsson, Giovanni Malerba, Ayse Demirkan, Juan Fernandez Tajes, Valgerdur Steinthorsdottir, Matthias Wuttke, Cécile Lecoeur, Michael Preuss, Lawrence F. Bielak, Marielisa Graff, Heather M. Highland, Anne E. Justice, Dajiang J. Liu, Eirini Marouli, 2018, Nature Genetics on p. 559-571
RVTESTS: An efficient and comprehensive tool for rare variant association analysis using sequence data
Xiaowei Zhan, Youna Hu, Bingshan Li, Goncalo R. Abecasis, Dajiang J. Liu, 2016, Bioinformatics on p. 1423-1426
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E. Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E. Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L. Young, Tamuno Alfred, Mary F. Feitosa, Nicholas G.D. Masca, Alisa K. Manning, Carolina Medina-Gomez, Poorva Mudgal, Maggie C.Y. Ng, Alex P. Reiner, Sailaja Vedantam, Sara M. Willems, Thomas W. Winkler, Gonçalo Abecasis, Katja K. Aben, Dewan S. Alam, Sameer E. Alharthi, Matthew Allison, Philippe Amouyel, Folkert W. Asselbergs, Paul L. Auer, Beverley Balkau, Lia E. Bang, Inês Barroso, Lisa Bastarache, Marianne Benn, Sven Bergmann, Lawrence F. Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A. Böger, Jette Bork-Jensen, Michiel L. Bots, Erwin P. Bottinger, Donald W. Bowden, Ivan Brandslund, Gerome Breen, Murray H. Brilliant, Linda Broer, Marco Brumat, Amber A. Burt, Adam S. Butterworth, Peter T. Campbell, Stefania Cappellani, David J. Carey, Eulalia Catamo, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Yii Der I. Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y. Chu, Massimiliano Cocca, James P. Cook, Janie Corley, Jordi Corominas Galbany, Amanda J. Cox, David S. Crosslin, Gabriel Cuellar-Partida, Angela D'Eustacchio, John Danesh, Gail Davies, Paul I.W. Bakker, Mark C.H. Groot, Renée Mutsert, Ian J. Deary, George Dedoussis, Ellen W. Demerath, Martin Heijer, Anneke I. Hollander, Hester M. Ruijter, Joe G. Dennis, Josh C. Denny, Emanuele Angelantonio, Fotios Drenos, Mengmeng Du, Marie Pierre Dubé, Alison M. Dunning, Douglas F. Easton, Todd L. Edwards, David Ellinghaus, Patrick T. Ellinor, Paul Elliott, Evangelos Evangelou, Aliki Eleni Farmaki, I. Sadaf Farooqi, Jessica D. Faul, Sascha Fauser, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C. Florez, Ian Ford, Myriam Fornage, Oscar H. Franco, Andre Franke, Paul W. Franks, Nele Friedrich, Ruth Frikke-Schmidt, Tessel E. Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Jane Gibson, Vilmantas Giedraitis, Anette P. Gjesing, Penny Gordon-Larsen, Mathias Gorski, Hans Jörgen Grabe, Struan F.A. Grant, Niels Grarup, Helen L. Griffiths, Megan L. Grove, Vilmundur Gudnason, Stefan Gustafsson, Jeff Haessler, Hakon Hakonarson, Anke R. Hammerschlag, Torben Hansen, Kathleen Mullan Harris, Tamara B. Harris, Andrew T. Hattersley, Christian T. Have, Caroline Hayward, Liang He, Nancy L. Heard-Costa, Andrew C. Heath, Iris M. Heid, Øyvind Helgeland, Jussi Hernesniemi, Alex W. Hewitt, Oddgeir L. Holmen, G. Kees Hovingh, Joanna M.M. Howson, Yao Hu, Paul L. Huang, Jennifer E. Huffman, M. Arfan Ikram, Erik Ingelsson, Anne U. Jackson, Jan Håkan Jansson, Gail P. Jarvik, Gorm B. Jensen, Yucheng Jia, Stefan Johansson, Marit E. Jørgensen, Torben Jørgensen, J. Wouter Jukema, Bratati Kahali, René S. Kahn, Mika Kähönen, Pia R. Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon L.R. Kardia, Fredrik Karpe, Sekar Kathiresan, Frank Kee, Lambertus A. Kiemeney, Eric Kim, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S. Kooner, Charles Kooperberg, Tellervo Korhonen, Peter Kovacs, Helena Kuivaniemi, Zoltán Kutalik, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, David Lamparter, Ethan M. Lange, Leslie A. Lange, Claudia Langenberg, Eric B. Larson, Nanette R. Lee, Terho Lehtimäki, Cora E. Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Honghuang Lin, Keng Hung Lin, Li An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching Ti Liu, Dajiang J. Liu, Yongmei Liu, Ken S. Lo, Artitaya Lophatananon, Andrew J. Lotery, Anu Loukola, Jian'An Luan, Steven A. Lubitz, Leo Pekka Lyytikäinen, Satu Männistö, Gaëlle Marenne, Angela L. Mazul, Mark I. McCarthy, Roberta McKean-Cowdin, Sarah E. Medland, Karina Meidtner, Lili Milani, Vanisha Mistry, Paul Mitchell, Karen L. Mohlke, Leena Moilanen, Marie Moitry, Grant W. Montgomery, Dennis O. Mook-Kanamori, Carmel Moore, Trevor A. Mori, Andrew D. Morris, Andrew P. Morris, Martina Müller-Nurasyid, Patricia B. Munroe, Mike A. Nalls, Narisu Narisu, Christopher P. Nelson, Matt Neville, Sune F. Nielsen, Kjell Nikus, Pål R. Njølstad, Børge G. Nordestgaard, Dale R. Nyholt, Jeffrey R. O'Connel, Michelle L. O'Donoghue, Loes M. Olde Loohuis, Roel A. Ophoff, Katharine R. Owen, Chris J. Packard, Sandosh Padmanabhan, Colin N.A. Palmer, Nicholette D. Palmer, Gerard Pasterkamp, Aniruddh P. Patel, Alison Pattie, Oluf Pedersen, Peggy L. Peissig, Gina M. Peloso, Craig E. Pennell, Markus Perola, James A. Perry, John R.B. Perry, Tune H. Pers, Thomas N. Person, Annette Peters, Eva R.B. Petersen, Patricia A. Peyser, Ailith Pirie, Ozren Polasek, Tinca J. Polderman, Hannu Puolijoki, Olli T. Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F. Reilly, Frida Renström, Myriam Rheinberger, Paul M. Ridker, John D. Rioux, Manuel A. Rivas, David J. Roberts, Neil R. Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S. Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J. Samani, Yadav Sapkota, Naveed Sattar, Robert E. Schoen, Pamela J. Schreiner, Matthias B. Schulze, Robert A. Scott, Marcelo P. Segura-Lepe, Svati H. Shah, Wayne H.H. Sheu, Xueling Sim, Andrew J. Slater, Kerrin S. Small, Albert V. Smith, Lorraine Southam, Timothy D. Spector, Elizabeth K. Speliotes, John M. Starr, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E. Stirrups, Konstantin Strauch, Heather M. Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Amy J. Swift, Hayato Tada, Katherine E. Tansey, Jean Claude Tardif, Kent D. Taylor, Alexander Teumer, Deborah J. Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H. Thuesen, Anke Tönjes, Gerard Tromp, Stella Trompet, Emmanouil Tsafantakis, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Jonathan P. Tyrer, Rudolf Uher, André G. Uitterlinden, Matti Uusitupa, Sander W. Laan, Cornelia M. Duijn, Nienke Leeuwen, Jessica Van Setten, Mauno Vanhala, Anette Varbo, Tibor V. Varga, Rohit Varma, Digna R. Velez Edwards, Sita H. Vermeulen, Giovanni Veronesi, Henrik Vestergaard, Veronique Vitart, Thomas F. Vogt, Uwe Völker, Dragana Vuckovic, Lynne E. Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A. Wang, Shuai Wang, Yiqin Wang, Erin B. Ware, Nicholas J. Wareham, Helen R. Warren, Dawn M. Waterworth, Jennifer Wessel, Harvey D. White, Cristen J. Willer, James G. Wilson, Daniel R. Witte, Andrew R. Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Pang Yao, Laura M. Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, Wei Zhou, Krina T. Zondervan, Jerome I. Rotter, John A. Pospisilik, Fernando Rivadeneira, Ingrid B. Borecki, Panos Deloukas, Timothy M. Frayling, Guillaume Lettre, Kari E. North, Cecilia M. Lindgren, Joel N. Hirschhorn, Ruth J.F. Loos, 2018, Nature Genetics on p. 26-35
Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
Leslie A. Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M. Schmidt, Zheng Zheng Tang, Chris Bizon, Ethan M. Lange, Joshua D. Smith, Emily H. Turner, Goo Jun, Hyun Min Kang, Gina Peloso, Paul Auer, Kuo Ping Li, Jason Flannick, Ji Zhang, Christian Fuchsberger, Kyle Gaulton, Cecilia Lindgren, Adam Locke, Alisa Manning, Xueling Sim, Manuel A. Rivas, Oddgeir L. Holmen, Omri Gottesman, Yingchang Lu, Douglas Ruderfer, Eli A. Stahl, Qing Duan, Yun Li, Peter Durda, Shuo Jiao, Aaron Isaacs, Albert Hofman, Joshua C. Bis, Adolfo Correa, Michael E. Griswold, Johanna Jakobsdottir, Albert V. Smith, Pamela J. Schreiner, Mary F. Feitosa, Qunyuan Zhang, Jennifer E. Huffman, Jacy Crosby, Christina L. Wassel, Ron Do, Nora Franceschini, Lisa W. Martin, Dajiang J. Liu, 2014, American Journal of Human Genetics on p. 233-245
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
Richard Karlsson Linnér, Travis T. Mallard, Peter B. Barr, Sandra Sanchez-Roige, James W. Madole, Morgan N. Driver, Holly E. Poore, Ronald de Vlaming, Andrew D. Grotzinger, Jorim J. Tielbeek, Emma C. Johnson, Mengzhen Liu, Sara Brin Rosenthal, Trey Ideker, Hang Zhou, Rachel L. Kember, Joëlle A. Pasman, Karin J.H. Verweij, Dajiang J. Liu, Scott Vrieze, Bernice Porjesz, Victor Hesselbrock, Tatiana M. Foroud, Arpana Agrawal, Howard J. Edenberg, John I. Nurnberger, Yunlong Liu, Samuel Kuperman, John Kramer, Jacquelyn L. Meyer, Chella Kamarajan, Ashwini K. Pandey, Laura Bierut, John Rice, Kathleen K. Bucholz, Marc A. Schuckit, Jay Tischfield, Andrew Brooks, Ronald P. Hart, Laura Almasy, Danielle M. Dick, Jessica E. Salvatore, Allison Goate, Manav Kapoor, Paul Slesinger, Denise M. Scott, Lance Bauer, Leah Wetherill, Xiaoling Xuei, Dongbing Lai, 2021, Nature Neuroscience on p. 1367-1376
News Articles Featuring Dajiang Liu
Jul 30, 2024
Genes or environment? A new model for understanding disease risk factors
A new model more accurately predicts how genetics and air pollution levels causally influence disease development; may help better assess disease risk and intervention strategies.
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Dec 12, 2023
Scientists say AI is emerging as potential tool to aid athletes, beat drug tests
AI could potentially be used by athletes looking for new ways to cheat
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Oct 25, 2023
Deciphering the genetic link between skin tone and ancestral origins
A team of Penn State geneticists is pursuing the answers to an age-old question of human biology: the genetic origin of fundamental variations in skin pigmentation between people of different ethnicities.
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Aug 25, 2023
College of Medicine faculty receive biomedical artificial intelligence grants
Penn State College of Medicine leaders awarded $225,000 in pilot funding to researchers as a part of its strategic plan focused on artificial intelligence and biomedical informatics.
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May 12, 2023
Daily smoking linked to brain shrinkage in massive study
A study involving more than 28,000 people strongly supports the idea that daily smoking shrinks the brain.
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Jan 26, 2023
Machine learning identifies drugs that could potentially help smokers quit
Medications like dextromethorphan, used to treat coughs caused by cold and flu, could potentially be repurposed to help people quit smoking cigarettes, according to a study by Penn State College of Medicine and University of Minnesota researchers.
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Dec 22, 2022
2022 Top 10 Most Popular Microbiome Center News Articles
The stories that made the year in 2022 for the Penn State Microbiome Center
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Dec 07, 2022
Drinking three glasses of wine a week could be in your DNA: The amount of alcohol you get through is 'significantly' influenced by your genes, study finds
If a bottle of wine disappears rather quickly after you open it, your genes may be partly to blame.
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Dec 07, 2022
Many genes linked to alcohol and tobacco use are shared among diverse ancestries
Penn State researchers co-led a large genetic study that identified more than 2,300 genes predicting alcohol and tobacco use after analyzing data from more than 3.4 million people.
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Jul 24, 2022
Predictive Model Uses Gut Microbes to Forecast Human Diseases, Health Outcomes
A new approach that uses artificial intelligence (AI) shows how to use microorganisms in the body and molecules in cells to predict human health outcomes, according to Penn State College of Medicine and University of Texas Southwestern Medical Center researchers.
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Jul 19, 2022
Predictive model uses gut microbes to forecast human diseases, health outcomes
A new approach that uses artificial intelligence (AI) shows how to use microorganisms in the body and molecules in cells to predict human health outcomes, according to Penn State College of Medicine and University of Texas Southwestern Medical Center researchers. They say it could improve the accuracy of predicting the development of human diseases, such as inflammatory bowel disease and diabetes.
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Jul 12, 2022
Student awarded fellowship to study the genetics of lupus in diverse populations
Keenan Anderson-Fears, a student from Penn State’s Bioinformatics and Genomics doctoral program, is one of six individuals nationally to receive the Gina M. Finzi Memorial Student Summer Fellowship from the Lupus Foundation of America.
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Jun 28, 2022
New machine learning technique shows how drugs can be repurposed
A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.
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Jun 28, 2022
New machine learning technique shows how drugs can be repurposed
A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.
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Sep 20, 2021
BG student named semifinalist for genetics research award
The American Society of Human Genetics (ASHG) has selected Chen Wang, a graduate student from Penn State’s doctoral program in bioinformatics and genomics, as a predoctoral semifinalist for the 2021 Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research.
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Sep 07, 2021
New tool reveals genetic influence of some sex-biased diseases, including lupus
Many human diseases can differ between males and females in their prevalence, manifestation, severity or age of onset. Examples include Lupus, where more than 80% of patients are females; Alzheimer’s disease, where females have higher incidence and tend to suffer quicker cognitive decline; and COVID-19 infections that are frequently more severe in males.
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Mar 30, 2021
New statistical method eases data reproducibility crisis
Researchers at Penn State and the University of Minnesota have developed a statistical tool that can accurately estimate the replicability of a study, thus eliminating the need to duplicate the work and effectively mitigating the reproducibility crisis.
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Apr 02, 2019
Scientists discover hundreds more genes with potential link to addictions
Many human diseases, such as tobacco and alcohol addictions, are heritable. Until now, little has been known about what genetic factors contribute to these addictions, and if they put people at risk of inheriting other medical conditions. A recent study, published in Nature Genetics, reveals that these addictions may result from a complex blend of genes and environmental influences, and are genetically correlated to other health issues and diseases.
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