Christian Huber
Assistant Professor of Biology
![Christian Huber](https://www.huck.psu.edu/assets/uploads/staff/_480x480_crop_center-center_100_none/cdh5313.jpg)
- He/Him/His
- cdh5313@psu.edu
- 814-863-6634
Research Summary
How evolutionary mechanisms such as mutation, recombination, and natural selection shape genetic diversity and the variability between individuals and species.
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Mutation Population Genes Genomics Demography Genome Mutation Rate Ancestry Pressure Genetic Variation Drosophila Melanogaster Viruses Introgression East Asia Coronavirinae Background Selection Far East Epidemics Flexibility Gene Expression Principal Component Analysis Coronavirus Rate Genetic Recombination Gene FlowMost Recent Publications
Population genetic simulation: Benchmarking frameworks for non-standard models of natural selection
Olivia L. Johnson, Raymond Tobler, Joshua M. Schmidt, Christian D. Huber, 2024, Molecular Ecology Notes
The Promise of Inferring the Past Using the Ancestral Recombination Graph
Debora Y.C. Brandt, Christian D. Huber, Charleston W.K. Chiang, Diego Ortega Del Vecchyo, 2024, Genome Biology and Evolution
The role of genetic selection and climatic factors in the dispersal of anatomically modern humans out of Africa
Raymond Tobler, Yassine Souilmi, Christian D. Huber, Nigel Bean, Chris S.M. Turney, Shane T. Grey, Alan Cooper, 2023, Proceedings of the National Academy of Sciences of the United States of America on p. e2213061120
Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass
Sonja Kersten, Jiyang Chang, Christian D. Huber, Yoav Voichek, Christa Lanz, Timo Hagmaier, Patricia Lang, Ulrich Lutz, Insa Hirschberg, Jens Lerchl, Aimone Porri, Yves Van de Peer, Karl Schmid, Detlef Weigel, Fernando A. Rabanal, 2023, Proceedings of the National Academy of Sciences of the United States of America
CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data
Deshan Perera, Elsa Reisenhofer, Said Hussein, Eve Higgins, Christian D. Huber, Quan Long, 2023, Methods in Ecology and Evolution on p. 2095-2109
Fluctuating selection and the determinants of genetic variation
Olivia Johnson, Raymond Tobler, Joshua Schmidt, Christian Huber, 2023, Trends in Genetics on p. 491-504
Admixture has obscured signals of historical hard sweeps in humans
Yassine Souilmi, Raymond Tobler, Angad Johar, Matthew Williams, Shane Grey, Joshua Schmidt, Joao Teixeira, Adam Rohrlach, Jonathan Tuke, Olivia Johnson, Graham Gower, Chris Turney, Murray Cox, Alan Cooper, Christian D. Huber, 2022, Nature Ecology and Evolution on p. 2003-2015
smartsnp, an r package for fast multivariate analyses of big genomic data
Salvador Herrando-Pérez, Raymond Tobler, Christian D. Huber, 2021, Methods in Ecology and Evolution on p. 2084-2093
The biasing impact of irrelevant contextual information on forensic odontology radiograph matching decisions
Sher Lin Chiam, Itiel E. Dror, Christian D. Huber, Denice Higgins, 2021, Forensic Science International
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9
Most-Cited Papers
The inflated significance of neutral genetic diversity in conservation genetics
João C. Teixeira, Christian D. Huber, 2021, Proceedings of the National Academy of Sciences of the United States of America
SweepFinder2: Increased sensitivity, robustness and flexibility
M DeGiorgio, Christian Huber, Melissa Hubisz, Ines Hellmann, Rasmus Nielsen, 2016, Bioinformatics on p. 1895--1897
Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2017, Genetics on p. 345-361
Detecting recent selective sweeps while controlling for mutation rate and background selection
Christian Huber, M DeGiorgio, Ines Hellmann, Rasmus Nielsen, 2016, Molecular Ecology on p. 142--156
Determining the factors driving selective effects of new nonsynonymous mutations
Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, Kirk E. Lohmueller, 2017, Proceedings of the National Academy of Sciences of the United States of America on p. 4465-4470
Gene expression drives the evolution of dominance
Christian D. Huber, Arun Durvasula, Angela M. Hancock, Kirk E. Lohmueller, 2018, Nature Communications
Deleterious variation shapes the genomic landscape of introgression
Bernard Y. Kim, Christian D. Huber, Kirk E. Lohmueller, 2018, PLoS Genetics
Similarities and differences in altitudinal versus latitudinal variation for morphological traits in drosophila melanogaster
Peter Klepsatel, Martina Gáliková, Christian D. Huber, Thomas Flatt, 2014, Evolution; international journal of organic evolution on p. 1385-1398
An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia
Yassine Souilmi, M. Elise Lauterbur, Ray Tobler, Christian D. Huber, Angad S. Johar, Shayli Varasteh Moradi, Wayne A. Johnston, Nevan J. Krogan, Kirill Alexandrov, David Enard, 2021, Current Biology on p. 3504-3514.e9
Keeping it local: Evidence for positive selection in swedish arabidopsis thaliana
Christian D. Huber, Magnus Nordborg, Joachim Hermisson, Ines Hellmann, 2014, Molecular Biology and Evolution on p. 3026-3039
News Articles Featuring Christian Huber
May 29, 2024
Complete X and Y chromosome sequences of living great ape species determined
Newly generated, complete “end-to-end” reference genomes for the sex chromosomes of five great ape species and one lesser ape species — produced by an international collaborative team led by researchers at Penn State, the National Human Genome Research Institute and the University of Washington — highlight extremely rapid changes on the male-specific Y chromosome among ape species.
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Nov 02, 2022
Ancient genomes reveal hidden history of human adaptation
It is widely believed that the genetics of our human ancestors did not change in response to environmental pressures as much as that of other animals. However, a new study comparing modern human genomes with ancient human DNA finds that certain genetic changes in humans may have been more common than previously thought.
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