Bioinformatics And Genomics News | Bioinformatics and Genomics

Dec 12, 2024

Center for Socially Responsible AI awards seed funding to seven diverse projects

The Penn State Center for Socially Responsible Artificial Intelligence (CSRAI) has announced the results of its most recent seed-funding competition.

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Penn State and U.S. National Science Foundation representatives cut a ribbon celebrating the official launch of the U.S. National Science Foundation National Synthesis Center for Emergence in the Molecular and Cellular Sciences (NCEMS) with the Penn State Nittany Lion mascot. The NCEMS launch took place on Monday, Nov. 18, and provided information about open calls for working groups, fellowships and internships, as well as a growth trajectory over the next five years. Credit: Keith Hickey/Huck Institutes. All Rights Reserved.

Dec 02, 2024

Heard on Campus: Launch of new center in molecular and cellular sciences, NCEMS

Reception celebrates new NSF-funded National Synthesis Center for Emergence in the Molecular and Cellular Sciences at Penn State.

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Nov 15, 2024

Q&A: How do microbiomes influence the study of life?

Microorganisms — bacteria, viruses and other tiny life forms — may drive biological variation in visible life as much, if not more, than genetic mutations, creating new lineages and even new species of animals and plants, according to Seth Bordenstein, director of Penn State’s One Health Microbiome Center within the Huck Institutes of the Life Sciences.

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The novel Cleavage High-throughput Assay (CHiTA) developed at Penn State provides a scarless method to characterize thousands of diverse small self-cleaving RNA enzymes, called twister ribozymes, in a single experiment. The image shows 2D models of some of the tested ribozymes that had imperfections in their helical and loop elements but were still active, demonstrating that twister ribozyme's ability to self-cleave is tolerant of these slight structural imperfections. Credit: Lauren McKinley and Philip Bevilacqua / Penn State. Creative Commons

Nov 06, 2024

Testing thousands of RNA enzymes helps find first ‘twister ribozyme’ in mammals

A new method, developed by Penn State researchers, can test the activity of thousands of predicted ribozymes in a single experiment.

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Oct 31, 2024

Huck researchers reflect on the 2024 Nobel Prize in Chemistry

This month, the Nobel Prize in Chemistry was awarded to three scientists credited with historic breakthroughs surrounding proteins and their structures. Three Huck researchers working on similar challenges chime in with their thoughts.

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Credit: Sean Anthony Eddy/Getty Images. All Rights Reserved.

Oct 25, 2024

Re-engineered, blue light-activated immune cells penetrate and kill solid tumors

A team led by researchers from the Penn State College of Medicine has re-engineered immune cells so that they can penetrate and kill solid tumors grown in the lab.

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Researchers developed a 3D atlas of the developing mouse brain, with such images as this. Credit: Provided by the Kim Lab / Penn State. Creative Commons

Oct 22, 2024

Researchers develop 3D atlas of the developing mammalian brain

A 3D atlas of developing mice brains using advanced imaging and microscopy techniques has been created by a team of researchers at Penn State College of Medicine and collaborators from five different institutes.

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Brianna Hnath, left, is doctoral candidate in biomedical engineering at Penn State and co-author of the study. Credit: Courtesy of the Dokholyan lab / Penn State. Creative Commons

Oct 14, 2024

Toxic protein may contribute to ALS development

New study elucidates the physiological processes that may contribute to ALS development and identifies a potential therapeutic target

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The researchers collected 58 bulk tank milk samples and applied various AI algorithms to differentiate between baseline samples and those representing potential anomalies, such as milk from an outside farm or milk containing antibiotics. Credit: SeanShot/Getty Images. All Rights Reserved.

Oct 11, 2024

AI decodes microbes’ message in milk safety testing approach

By combining the genetic sequencing and analysis of the microbes in a milk sample with artificial intelligence (AI), researchers were able to detect anomalies in milk production, such as contamination or unauthorized additives.

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New experimental technique developed by Penn State researchers helps uncover how certain proteins cooperate to bind to otherwise closed regions of the genome to facilitate cell differentiation and development. Illustration shows expanded view of chromosome from a cell at the upper left. The “pioneer factor” FOXA1 co-binds with AP-1, allowing FOXA1 to locate target sites in the genome with high specificity. Credit: Holly Godin/Bai Laboratory / Penn State.

Sep 11, 2024

Genomic pioneers collaborate to access the inaccessible

A new experimental method allows researchers to dissect how certain proteins, called pioneer factors, can bind to selective regions of the genome that are inaccessible to other DNA binding proteins.

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