Integrative Dynamic Omics for Personalized Medicine
George I Mias, Stanford University School of Medicine
November 5, 2013 @ 04:00 pm to 05:00 pm
100 Life Sciences, Berg Auditorium, VC to Hershey COM CG623
Dr. Mias is a post doctoral scholar with Professor Michael Snyder's lab at the Stanford University School of Medicine in the Department of Genetics. ABSTRACT The advent of readily_available -omics_technologies will greatly aid the advancement of the emerging_field ofpersonalized medicine.__In_particular, novel medical insights_are_expected through the integration of_genomic information with the_global monitoring of molecular components and_physiologicalstates.__In a proof-of-principle_study to explore_such omics_integration and personalized health applicability,_multiple omics profiles_were obtained from an initially healthy individual_for a period of (now)over three years.__This included_observations spanning multiple_healthy and virally infected states, as_well as the onset of Type 2_Diabetes, which was clinically diagnosed at the_later stages ofthe_investigation.__Initially the_individual s whole genome_was determined and used to estimate medical risks.__The genomic data_was then coupled to an_integrated Personal Omics_Profiling analysis,which included the combined_dynamical monitoring of the transcriptome,_proteome and metabolome.__The integrative omics analysis of blood_constituents_revealed extensive, dynamic and broad changes in diversemolecular components.__The emerging patterns were classified and_associated_to biological pathways, relevant to the_varying healthy_and disease conditions.__This study was the first to implementthe_integration of such omics information for an individual, obtained_across dynamical_physiological_states, providing a medically relevant_interpretation with_potential applications to_a more personalized,precise and preventative_medicine. _ _
Contact
Megan Matthews
mam75@psu.edu
814-865-2625