Multiwavelength analytical ultracentrifugation (MW-AUC) on the Beckman Coulter Optima AUC platform enables high-resolution analysis of complex mixtures by combining sedimentation velocity with full-spectrum UV/Vis detection.
This technique allows for the simultaneous monitoring of multiple species based on both their hydrodynamic and spectral properties, making it particularly powerful for studying interacting systems, co-migrating components, or formulations with overlapping absorbance. MW-AUC provides unique insights into molecular size, shape, stoichiometry, and heterogeneity in native solution conditions, without the need for labeling or immobilization.
Instrumentation
Beckman Optima Multiwavelength Analytical Ultracentrifuge