Authored Papers

Saon MS, Douds CA, Veenis AJ, Pearson AN, Yennawar NH, Bevilacqua PC. Identification and characterization of shifted G•U wobble pairs resulting from alternative protonation of RNA. bioRxiv [Preprint]. 2025 Jan 2:2024.12.31.630957. doi: 10.1101/2024.12.31.630957. PMID: 39803426; PMCID: PMC11722211.

Wang B, Solinski AE, Radle MI, Peduzzi OM, Knox HL, Cui J, Maurya RK, Yennawar NH, Booker SJ. Structural Evidence for DUF512 as a Radical S-Adenosylmethionine Cobalamin-Binding Domain. ACS Bio Med Chem Au. 2024 Oct 23;4(6):319-330. doi: 10.1021/acsbiomedchemau.4c00067. PMID: 39712206; PMCID: PMC11659888.

Aponte-Diaz D, Harris JM, Kang TE, Korboukh V, Sotoudegan MS, Gray JL, Yennawar NH, Moustafa IM, Macadam A, Cameron CE. Non-lytic spread of poliovirus requires the nonstructural protein 3CD. mBio. 2025 Jan 8;16(1):e0327624. doi: 10.1128/mbio.03276-24. Epub 2024 Dec 12. PMID: 39665531; PMCID: PMC11708018.

Chatterjee D, Zhang Z, Lin PY, Wang PH, Sidhu GK, Yennawar NH, Hsieh JA, Chen PY, Song R, Meyers BC, Chopra S. Maize unstable factor for orange1 encodes a nuclear protein that affects redox accumulation during kernel development. Plant Cell. 2024 Dec 23;37(1):koae301. doi: 10.1093/plcell/koae301. PMID: 39589935; PMCID: PMC11663571.

Mitra R, Usher ET, Dedeoğlu S, Crotteau MJ, Fraser OA, Yennawar NH, Gadkari VV, Ruotolo BT, Holehouse AS, Salmon L, Showalter SA, Bardwell JCA. Molecular insights into the interaction between a disordered protein and a folded RNA. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2409139121. doi: 10.1073/pnas.2409139121. Epub 2024 Nov 26. PMID: 39589885; PMCID: PMC11626198.

Aponte-Diaz D, Harris JM, Kang TE, Korboukh V, Sotoudegan MS, Gray JL, Yennawar NH, Moustafa IM, Macadam A, Cameron CE. Non-lytic spread of poliovirus requires the nonstructural protein 3CD. bioRxiv [Preprint]. 2024 Oct 19:2024.10.18.619132. doi: 10.1101/2024.10.18.619132. Update in: mBio. 2025 Jan 8;16(1):e0327624. doi: 10.1128/mbio.03276-24. PMID: 39464037; PMCID: PMC11507938.

Beech JL, Fecko JA, Yennawar N, DuBois JL. Functional and spectroscopic approaches to determining thermal limitations of Rieske oxygenases. Methods Enzymol. 2024;703:299-328. doi: 10.1016/bs.mie.2024.05.021. Epub 2024 Jun 29. PMID: 39261001; PMCID: PMC11521362.

Mitra R, Usher ET, Dedeoğlu S, Crotteau MJ, Fraser OA, Yennawar NH, Gadkari VV, Ruotolo BT, Holehouse AS, Salmon L, Showalter SA, Bardwell JCA. Molecular insights into the interaction between a disordered protein and a folded RNA. bioRxiv [Preprint]. 2024 Jun 12:2024.06.12.598678. doi: 10.1101/2024.06.12.598678. Update in: Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2409139121. doi: 10.1073/pnas.2409139121. PMID: 38915483; PMCID: PMC11195163.

Potter JR, Rivera S, Young PG, Patterson DC, Namitz KE, Yennawar N, Kincaid JR, Liu Y, Weinert EE. Heme pocket modulates protein conformation and diguanylate cyclase activity of a tetrameric globin coupled sensor. J Inorg Biochem. 2024 Sep;258:112638. doi: 10.1016/j.jinorgbio.2024.112638. Epub 2024 Jun 8. PMID: 38878680.

Prakash D, Xiong J, Chauhan SS, Walters KA, Kruse H, Yennawar N, Golbeck JH, Guo Y, Ferry JG. Catalytic Activity of the Archetype from Group 4 of the FTR-like Ferredoxin:Thioredoxin Reductase Family Is Regulated by Unique S = 7/2 and S = 1/2 [4Fe-4S] Clusters. Biochemistry. 2024 Jun 18;63(12):1588-1598. doi: 10.1021/acs.biochem.3c00651. Epub 2024 May 31. PMID: 38817151; PMCID: PMC11234629.

Lu X, Cummings C, Osuala UA, Yennawar NH, Namitz KEW, Hellner B, Besada-Lombana PB, Peterson RD, Clark AJ. Characterization of recombinant human lactoferrin expressed in Komagataella phaffii. Analyst. 2024 Jun 24;149(13):3636-3650. doi: 10.1039/d4an00333k. PMID: 38814097; PMCID: PMC11215759.

Beech JL, Maurya AK, Rodrigues da Silva R, Akpoto E, Asundi A, Fecko JA, Yennawar NH, Sarangi R, Tassone C, Weiss TM, DuBois JL. Understanding the stability of a plastic-degrading Rieske iron oxidoreductase system. Protein Sci. 2024 Jun;33(6):e4997. doi: 10.1002/pro.4997. PMID: 38723110; PMCID: PMC11081424.

Vishweshwaraiah YL, Hnath B, Wang J, Chandler M, Mukherjee A, Yennawar NH, Booker SJ, Afonin KA, Dokholyan NV. A Piecewise Design Approach to Engineering a Miniature ACE2 Mimic to Bind SARS-CoV-2. ACS Appl Bio Mater. 2024 May 20;7(5):3238-3246. doi: 10.1021/acsabm.4c00222. Epub 2024 May 3. PMID: 38700999; PMCID: PMC11586090.

Nguyen NA, Vidya FNU, Yennawar NH, Wu H, McShan AC, Agarwal V. Disordered regions in proteusin peptides guide post-translational modification by a flavin-dependent RiPP brominase. Nat Commun. 2024 Feb 10;15(1):1265. doi: 10.1038/s41467-024-45593-5. PMID: 38341413; PMCID: PMC10858898.

Schuelke-Sanchez A, Yennawar NH, Weinert EE. Oxygen-selective regulation of cyclic di-GMP synthesis by a globin coupled sensor with a shortened linking domain modulates Shewanella sp. ANA-3 biofilm. J Inorg Biochem. 2024 Mar;252:112482. doi: 10.1016/j.jinorgbio.2024.112482. Epub 2024 Jan 8. PMID: 38218138; PMCID: PMC11616453.

Mattocks JA, Jung JJ, Lin CY, Dong Z, Yennawar NH, Featherston ER, Kang-Yun CS, Hamilton TA, Park DM, Boal AK, Cotruvo JA Jr. Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer. Nature. 2023 Jun;618(7963):87-93. doi: 10.1038/s41586-023-05945-5. Epub 2023 May 31. PMID: 37259003; PMCID: PMC10232371.

Vishweshwaraiah YL, Hnath B, Rackley B, Wang J, Gontu A, Chandler M, Afonin KA, Kuchipudi SV, Christensen N, Yennawar NH, Dokholyan NV. Adaptation-proof SARS-CoV-2 vaccine design. Adv Funct Mater. 2022 Dec 2;32(49):2206055. doi:10.1002/adfm.202206055. Epub 2022 Oct 3. PMID: 36590650; PMCID: PMC9799234.

Yeager C, Carter G, Gohara DW, Yennawar NH, Enemark EJ, Arnold JJ, Cameron CE. Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. Nucleic Acids Res. 2022 Nov 11;50(20):11775-11798. doi: 10.1093/nar/gkac1054. PMID: 36399514; PMCID: PMC9723501.

Sieg JP, McKinley LN, Huot MJ, Yennawar NH, Bevilacqua PC. The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability. Biochemistry. 2022 Nov 15;61(22):2579-2591. doi: 10.1021/acs.biochem.2c00488. Epub 2022 Oct 28. PMID: 36306436; PMCID: PMC9669196.

Vishweshwaraiah YL, Hnath B, Rackley B, Wang J, Gontu A, Chandler M, Afonin KA, Kuchipudi SV, Christensen N, Yennawar NH, Dokholyan NV. Adaptation-proof SARS-CoV-2 vaccine design. bioRxiv [Preprint]. 2022 May 18:2022.05.17.492310. doi: 10.1101/2022.05.17.492310. Update in: Adv Funct Mater. 2022 Dec 2;32(49):2206055. doi: 10.1002/adfm.202206055. PMID: 35611332; PMCID: PMC9128779.

Xu Y, Zu R, Yennawar NH, Gopalan V, Hickey RJ. Cocrystalline Polymer Films Exhibiting Second-Order Nonlinear Optical Properties. ACS Macro Lett. 2021 Oct 19;10(10):1216-1222. doi: 10.1021/acsmacrolett.1c00345. Epub 2021 Sep 21. PMID: 35549037.

Patterson DC, Liu Y, Das S, Yennawar NH, Armache JP, Kincaid JR, Weinert EE. Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo- Dimeric Sensor Protein. Biochemistry. 2021 Dec 14;60(49):3801-3812. doi: 10.1021/acs.biochem.1c00581. Epub 2021 Nov 29. PMID: 34843212.

Yoon J, Hou Y, Knoepfel AM, Yang D, Ye T, Zheng L, Yennawar N, Sanghadasa M, Priya S, Wang K. Bio-inspired strategies for next-generation perovskite solar mobile power sources. Chem Soc Rev. 2021 Nov 29;50(23):12915-12984. doi: 10.1039/d0cs01493a. PMID: 34622260. 24: Esakova OA, Grove TL, Yennawar NH, Arcinas AJ, Wang B, Krebs C, Almo SC, Booker SJ. Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB. Nature. 2021 Sep;597(7877):566-570. doi: 10.1038/s41586-021-03904-6. Epub 2021 Sep 15. PMID: 34526715; PMCID: PMC9107155.

Patterson DC, Ruiz MP, Yoon H, Walker JA, Armache JP, Yennawar NH, Weinert EE. Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2100657118. doi: 10.1073/pnas.2100657118. PMID: 34475207; PMCID: PMC8433548.

Chatterjee D, Wittmeyer K, Lee TF, Cui J, Yennawar NH, Yennawar HP, Meyers BC, Chopra S. Maize unstable factor for orange1 is essential for endosperm development and carbohydrate accumulation. Plant Physiol. 2021 Aug 3;186(4):1932-1950. doi: 10.1093/plphys/kiab183. PMID: 33905500; PMCID: PMC8331166.

Bansia H, Mahanta P, Yennawar NH, Ramakumar S. Small Glycols Discover Cryptic Pockets on Proteins for Fragment-Based Approaches. J Chem Inf Model. 2021 Mar 22;61(3):1322-1333. doi: 10.1021/acs.jcim.0c01126. Epub 2021 Feb 11. PMID: 33570386.

Kim SA, Zhu J, Yennawar N, Eek P, Tan S. Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. Mol Cell. 2020 Jun 4;78(5):903-914.e4. doi: 10.1016/j.molcel.2020.04.019. Epub 2020 May 11. PMID: 32396821; PMCID: PMC7275924.

Leamy KA, Yamagami R, Yennawar NH, Bevilacqua PC. Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23075-23082. doi: 10.1073/pnas.1913418116. Epub 2019 Oct 30. PMID: 31666318; PMCID: PMC6859320.

Esakova OA, Silakov A, Grove TL, Warui DM, Yennawar NH, Booker SJ. An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase. J Am Chem Soc. 2019 Sep 11;141(36):14142-14151. doi: 10.1021/jacs.9b02513. Epub 2019 Aug 26. PMID: 31390192; PMCID: PMC7029380.

Van Buiten CB , Yennawar NH , Pacheco CN , Hatzakis E , Elias RJ . Physicochemical interactions with (-)-epigallocatechin-3-gallate drive structural modification of celiac-associated peptide α₂-gliadin (57-89) at physiological conditions. Food Funct. 2019 May 22;10(5):2997-3007. doi: 10.1039/c9fo00553f. PMID: 31086895.

Rose HR, Maggiolo AO, McBride MJ, Palowitch GM, Pandelia ME, Davis KM, Yennawar NH, Boal AK. Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis. Biochemistry. 2019 Apr 9;58(14):1845-1860. doi: 10.1021/acs.biochem.8b01252. Epub 2019 Mar 22. PMID: 30855138; PMCID: PMC6456427.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. PMID: 30220459; PMCID: PMC6219629.

Leamy KA, Yennawar NH, Bevilacqua PC. Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms. Biochemistry. 2018 May 22;57(20):2994-3002. doi: 10.1021/acs.biochem.8b00345. Epub 2018 May 7. PMID: 29733204; PMCID: PMC6726375.

DiMarzio M, Rusconi B, Yennawar NH, Eppinger M, Patterson AD, Dudley EG. Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA. PLoS One. 2017 Sep 14;12(9):e0183564. doi: 10.1371/journal.pone.0183564. PMID: 28910295; PMCID: PMC5598929.

Leamy KA, Yennawar NH, Bevilacqua PC. Cooperative RNA Folding under Cellular Conditions Arises From Both Tertiary Structure Stabilization and Secondary Structure Destabilization. Biochemistry. 2017 Jul 11;56(27):3422-3433. doi: 10.1021/acs.biochem.7b00325. Epub 2017 Jun 28. PMID: 28657303; PMCID: PMC5542450.

Bingaman JL, Zhang S, Stevens DR, Yennawar NH, Hammes-Schiffer S, Bevilacqua PC. The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme. Nat Chem Biol. 2017 Apr;13(4):439-445. doi: 10.1038/nchembio.2300. Epub 2017 Feb 13. PMID: 28192411; PMCID: PMC5362308.

Glisan SL, Grove KA, Yennawar NH, Lambert JD. Inhibition of pancreatic lipase by black tea theaflavins: Comparative enzymology and in silico modeling studies. Food Chem. 2017 Feb 1;216:296-300. doi: 10.1016/j.foodchem.2016.08.052. Epub 2016 Aug 18. PMID: 27596423; PMCID: PMC5228287.

Esakova OA, Silakov A, Grove TL, Saunders AH, McLaughlin MI, Yennawar NH, Booker SJ. Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid. J Am Chem Soc. 2016 Jun 15;138(23):7224-7. doi: 10.1021/jacs.6b02708. Epub 2016 Jun 2. PMID: 27224840.

Yennawar NH, Fecko JA, Showalter SA, Bevilacqua PC. A High-Throughput Biological Calorimetry Core: Steps to Startup, Run, and Maintain a Multiuser Facility. Methods Enzymol. 2016;567:435-60. doi: 10.1016/bs.mie.2015.07.024. Epub 2015 Sep 5. PMID: 26794364; PMCID: PMC6474912.

Yenugudhati D, Prakash D, Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity. Biochemistry. 2016 Jan 19;55(2):313-21. doi: 10.1021/acs.biochem.5b00823. Epub 2015 Dec 30. PMID: 26684934.

Moustafa IM, Gohara DW, Uchida A, Yennawar N, Cameron CE. Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome? Viruses. 2015 Nov 23;7(11):5962-86. doi: 10.3390/v7112919. Erratum in: Viruses. 2015 Dec;7(12):6537. PMID: 26610545; PMCID: PMC4664992.

Moustafa IM, Uchida A, Wang Y, Yennawar N, Cameron CE. Structural models of mammalian mitochondrial transcription factor B2. Biochim Biophys Acta. 2015 Aug;1849(8):987-1002. doi: 10.1016/j.bbagrm.2015.05.010. Epub 2015 Jun 8. PMID: 26066983.

Kumar AK, Kumar RS, Yennawar NH, Yennawar HP, Ferry JG. Structural and Biochemical Characterization of a Ferredoxin:Thioredoxin Reductase-like Enzyme from Methanosarcina acetivorans. Biochemistry. 2015 May 19;54(19):3122-8. doi: 10.1021/acs.biochem.5b00137. PMID: 25915695.

Guo F, Zhou W, Li P, Mao Z, Yennawar NH, French JB, Huang TJ. Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves. Small. 2015 Jun;11(23):2733-7. doi: 10.1002/smll.201403262. Epub 2015 Feb 1. PMID: 25641793; PMCID: PMC4478196.

Wang X, Yennawar N, Hankey PA. Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain. Cell Commun Signal. 2014 Apr 16;12:28. doi: 10.1186/1478-811X-12-28. PMID: 24739671; PMCID: PMC4021555.

Sysoeva TA, Yennawar N, Allaire M, Nixon BT. Crystallization and preliminary X-ray analysis of the ATPase domain of the σ(54)-dependent transcription activator NtrC1 from Aquifex aeolicus bound to the ATP analog ADP-BeFx. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1384-8. doi:10.1107/S174430911302976X. Epub 2013 Nov 29. PMID: 24316836; PMCID: PMC3855726.

Wörsdörfer B, Lingaraju M, Yennawar NH, Boal AK, Krebs C, Bollinger JM Jr, Pandelia ME. Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18874-9. doi: 10.1073/pnas.1315927110. Epub 2013 Nov 6. PMID: 24198335; PMCID: PMC3839769.

Strulson CA, Yennawar NH, Rambo RP, Bevilacqua PC. Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions. Biochemistry. 2013 Nov 19;52(46):8187-97. doi: 10.1021/bi400816s. Epub 2013 Nov 4. PMID: 24187989; PMCID: PMC3882164.

Georgelis N, Yennawar NH, Cosgrove DJ. Structural basis for entropy-driven cellulose binding by a type-A cellulose-binding module (CBM) and bacterial expansin. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14830-5. doi: 10.1073/pnas.1213200109. Epub 2012 Aug 27. PMID: 22927418; PMCID: PMC3443152.