The VP-capillary DSC is the most sensitive, easy-to-use differential scanning calorimeter to study samples in solution, providing fast, accurate transition midpoint (Tm) determination and ΔH.
Uses
- Study macromolecular folding stability:
- Effects of protein mutagenesis and engineering
- Effects of buffer, pH, salt, additives
- Effects of post-translational modification
- Reversibility of unfolding, by changes in ΔH
- Presence of multiple unfolding domains
- Stability contributions of individual domains
- Formation of protein complexes
- Stability of oligonucelotides
- Effects of lipid, nucleic acid, or other biopolymer on protein stability
Specifications
- Operating temperature range: -10°C to 130°C
- Minimum response time (high gain): 5 seconds
- Cell design: Tantalum 130 µl capillary type
- Short term noise: 0.6µcal/°C
- Baseline reliability: 1.5 µcal/°C