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Featured Stories

Vaccine-induced false positives are a major roadblock in the development and approval of an HIV vaccine, according to a research team at Penn State. The researchers developed a test that can differentiate between false positives and active HIV infections.  Credit: MicroStockHub/Getty Images. All Rights Reserved.

New test distinguishes vaccine-induced false positives from active HIV infection

A Penn State team has developed a new approach capable of differentiating active HIV infection from false positives — which could potentially accelerate vaccine development and testing.

Full Article

Yangbo Yuan, a graduate student in engineering science and mechanics, and lead Huanyu “Larry” Cheng, James L. Henderson, Jr. Memorial Associate Professor of Engineering Science and Mechanics in the College of Engineering, pose with their proof-of-concept test device — a wearable ring with an embedded, miniaturized accelerometer. Credit: Courtney Robinson / Penn State. Creative Commons

Shrinking materials hold big potential for smart devices, researchers say

Wearable electronics could be more wearable, according to a research team at Penn State. The researchers developed a scalable, versatile approach to designing and fabricating wireless, internet-enabled electronic systems that can better adapt to 3D surfaces, like the human body or common household items, paving the path for more precise health monitoring or household automation, such as a smart recliner that can monitor and co

Full Article

Patrick Drew is leading a research team in investigating a rare neuron that appears to play a significant role in regulating blood flow in the brain of mice. Credit: Kelby Hochreither/Penn State. All Rights Reserved.

It’s not just in your head: Stress may lead to altered blood flow in the brain

Researchers at Penn State find a rare, stress-sensitive neuron appears to help regulate blood flow in the brain of mice.

Full Article

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Study first author Michelle Zavala-Paez, doctoral candidate in Penn State’s Intercollege Graduate Degree Program in Ecology, selects the main shoot of a hybrid Populus tree to collect the first fully expanded leaf for physiological measurements. Credit: Penn State. Creative Commons

Dec 18, 2025

Genetic teamwork may be the secret to climate-resilient plants, researchers find

A plant’s success may depend on how well the three sets of genetic instructions it carries in its cells cooperate, according to a new study led by plant scientists at Penn State.

A new high-throughput study that used publicly available data shows that E. coli proteins containing a structure called a non-covalent lasso entanglement (NCLE) are more likely to misfold and, if they are essential to the bacteria’s survival, more likely to be repaired by chaperones — the cell’s quality control machinery. Image shows that misfolded (outlined in red) essential proteins (bottom) containing NCLEs are more likely to be repaired (outlined in green) by cellular chaperones (dark grey) than non-essential proteins (top). Credit: Ian Sitarik/O’Brien Lab / Penn State. Creative Commons

Dec 16, 2025

For certain life-essential proteins in E. coli, repair is more likely

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. A new study by researchers at Penn State found that, in E. coli, proteins containing a widespread structural 3D pattern, known as a motif, are more likely to misfold than proteins that lack it.

Researchers at Penn State found that two proteins thought to operate in harmony to regulate the genetic information-carrying messenger molecules called mRNA actually work in opposition: one protein destabilizes mRNA while the other steadies it. Credit: wildpixel/Getty Images. All Rights Reserved.

Dec 16, 2025

Opposing forces in cells could hold clues to treating disease

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders — including cancers, neurodegenerative diseases and immune disorders — originate, as well as how to potentially treat them, according to researchers at Penn State.

News

Study first author Michelle Zavala-Paez, doctoral candidate in Penn State’s Intercollege Graduate Degree Program in Ecology, selects the main shoot of a hybrid Populus tree to collect the first fully expanded leaf for physiological measurements. Credit: Penn State. Creative Commons

Dec 18, 2025

Genetic teamwork may be the secret to climate-resilient plants, researchers find

A plant’s success may depend on how well the three sets of genetic instructions it carries in its cells cooperate, according to a new study led by plant scientists at Penn State.

A new high-throughput study that used publicly available data shows that E. coli proteins containing a structure called a non-covalent lasso entanglement (NCLE) are more likely to misfold and, if they are essential to the bacteria’s survival, more likely to be repaired by chaperones — the cell’s quality control machinery. Image shows that misfolded (outlined in red) essential proteins (bottom) containing NCLEs are more likely to be repaired (outlined in green) by cellular chaperones (dark grey) than non-essential proteins (top). Credit: Ian Sitarik/O’Brien Lab / Penn State. Creative Commons

Dec 16, 2025

For certain life-essential proteins in E. coli, repair is more likely

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease. A new study by researchers at Penn State found that, in E. coli, proteins containing a widespread structural 3D pattern, known as a motif, are more likely to misfold than proteins that lack it.

Researchers at Penn State found that two proteins thought to operate in harmony to regulate the genetic information-carrying messenger molecules called mRNA actually work in opposition: one protein destabilizes mRNA while the other steadies it. Credit: wildpixel/Getty Images. All Rights Reserved.

Dec 16, 2025

Opposing forces in cells could hold clues to treating disease

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders — including cancers, neurodegenerative diseases and immune disorders — originate, as well as how to potentially treat them, according to researchers at Penn State.

Researchers used advanced imaging techniques, conducted at Penn State’s publicly funded Core Facilities, to study the architecture of the Turnip Crinkle Virus (TCV). This plant pathogen has an icosahedral — or 20-sided — shell that is the same structure as many human pathogens, such as enteroviruses, noroviruses, poliovirus, hepatitis B virus and the virus that causes chickenpox. Pictured are Varun Venkatakrishnan, left, a Penn State doctoral student, and Ganesh Anand, associate professor of chemistry, biochemistry and molecular biology at Penn State.  Credit: Michelle Bixby / Penn State. Creative Commons

Dec 12, 2025

Unique bond identified as key to viral infection speed

Viruses are typically described as tiny, perfectly geometric shells that pack genetic material with mathematical precision, but new research led by scientists at Penn State revealed a deliberate imbalance in their shape that helps them infect their hosts.

Events

Friday Jan

09

OHMC Winter 2026 Networking Event

Microbiome Center

Thursday Jan

15

CIDD Seminar with Dr. Rushika Perera

Center for Infectious Disease Dynamics

Wednesday Jan

21

Center for Structural Biology Seminar

Center for Structural Biology

Events

Friday Jan

09

OHMC Winter 2026 Networking Event

Microbiome Center

Thursday Jan

15

CIDD Seminar with Dr. Rushika Perera

Center for Infectious Disease Dynamics

Wednesday Jan

21

Center for Structural Biology Seminar

Center for Structural Biology

Friday Jan

23

Seminar: Microbial Crossroads – Food Production, Animal Health & Public Health

Microbiome Center

 

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